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Viral gene drive spread during herpes simplex virus 1 infection in mice.
Nat Commun
September 2024
Buck Institute for Research on Aging, Novato, CA, US.
Article Synopsis
- Gene drives are genetic tools created to spread specific modifications through populations, and a new approach has been developed for herpesviruses that uses co-infection of engineered and wild-type viruses.* -
- This research focused on a gene drive targeting human herpes simplex virus 1 (HSV-1), demonstrating its ability to propagate in cell cultures and during infections in mice, particularly affecting neuronal tissues.* -
- The study revealed significant co-infection and recombination rates in HSV-1, suggesting that these gene drives could serve as potential therapies by effectively spreading genetic modifications during viral infections.*