A research-driven flowchart to approach change in couples.

In most cases, couple therapists systemically see couples' distress as the result of reciprocal maladaptive patterns to which each partner contributes. Yet, therapists can struggle to share with the couple such a relational understanding of their distress and identify goals for change accordingly, as structured, step-by-step methods are not available in the extant literature. This perspective paper reviews research across various domains of relationship science to summarize cohesively the best practices for goal identification in a step-by-step flowchart.

Implementation of a national programme to train and support healthcare professionals in brief behavioural interventions: A qualitative study using the theoretical domains framework.

Objectives: Behaviour change interventions offered opportunistically by healthcare professionals can support patient health behaviour change. The Making Every Contact Count (MECC) programme in Ireland is a national programme to support healthcare professionals to use brief behavioural interventions. The aim of this study was to gain an in-depth understanding of the enablers of, and barriers to, embedding MECC across the healthcare system.

Developmental exposure to legacy environmental contaminants, medial temporal lobe volumes and spatial navigation memory in late adolescents.

Exposure to lead, mercury, and polychlorinated biphenyls (PCBs) has been causally linked to spatial memory deficits and hippocampal changes in animal models. The Inuit community in Northern Canada is exposed to higher concentrations of these contaminants compared to the general population. This study aimed to 1) investigate associations between prenatal and current contaminant exposures and medial temporal brain volumes in Inuit late adolescents; 2) examine the relationship between these brain structures and spatial memory; and 3) assess the mediating role of brain structures in the association between contaminant exposure and spatial memory.

Nrf2 mediates mitochondrial and NADPH oxidase-derived ROS during mild heat stress at 40 °C.

Hyperthermia is an adjuvant to chemotherapy and radiotherapy and sensitizes tumors to these treatments. However, repeated heat treatments result in acquisition of heat resistance (thermotolerance) in tumors. Thermotolerance is an adaptive survival response that appears to be mediated by upregulated cellular defenses.

A multiscale model for multivariate time series forecasting.

Transformer based models for time-series forecasting have shown promising performance and during the past few years different Transformer variants have been proposed in time-series forecasting domain. However, most of the existing methods, mainly represent the time-series from a single scale, making it challenging to capture various time granularities or ignore inter-series correlations between the series which might lead to inaccurate forecasts. In this paper, we address the above mentioned shortcomings and propose a Transformer based model which integrates multi-scale patch-wise temporal modeling and channel-wise representation.

e-Health Interventions for Promoting Physical Activity in Aging Adults: A Scoping Review.

The use of e-health interventions to promote physical activity (PA) among older adults has significantly increased in recent years. This review aims to comprehensively summarize the various e-health modalities and strategies used to encourage PA in aging adults. A systematic search of Medline, Embase, CINAHL, AMED, and PubMed databases was conducted to identify studies on e-health interventions targeting PA promotion in individuals aged 50 and older, published between 2012 and 2023.

Differential bioaccumulation and histopathological changes induced by iron oxide nanoparticles and ferric chloride in the neotropical snail Biomphalaria glabrata.

Iron oxide nanoparticles (IONPs) are prominent in nanomedicine, cosmetics, and environmental applications. However, their increasing production, use, and release into the environment raises concerns about their potential risks to aquatic life and human health. This study aimed to evaluate the bioaccumulation, as concentration of small, medium and large iron aggregates in the digestive tubules, histopathological changes, and inflammatory responses in the freshwater snail Biomphalaria glabrata following chronic exposure to gluconic-acid functionalized IONPs (GLA-IONPs) compared to their dissolved counterpart (FeCl).

De novo transcriptome assembly and discovery of drought-responsive genes in white spruce (Picea glauca).

Forests face an escalating threat from the increasing frequency of extreme drought events driven by climate change. To address this challenge, it is crucial to understand how widely distributed species of economic or ecological importance may respond to drought stress. In this study, we examined the transcriptome of white spruce (Picea glauca (Moench) Voss) to identify key genes and metabolic pathways involved in the species' response to water stress.

Analysis of the International Index of Erectile Function: psychometric evidence and measurement invariance across relationship status and age generations in a Chilean sample.

Background: The International Index of Erectile Function (IIEF) stands out for its utility and widespread use to measure sexual function in men. However, it lacks consistency in its internal latent structure across studies, has not been evaluated for measurement invariance, and has not undergone psychometric validation for its 15-item form in Spanish among South American countries.

Aim: To examine the IIEF's psychometric evidence (ie, structural/criterion validity and reliability) in a sample of adult men and determine its measurement invariance across relationship status (single vs in a relationship) and age generations (generations Z, Y/millennials, and X).

Relationship with Adults in Organized Sports and Non-Sports Activities and Links with Psychological Adjustment in Adolescence: A 6-Year Longitudinal Study.

Relationships with adults in organized activities play a crucial role in the positive outcomes associated with these experiences, yet little is known about how these relationships evolve throughout adolescence or how they are differentially associated with mental health. Important distinctions could also be made regarding activity types. The sample consisted of 292 participants (58% female; M age = 12.

Evaluating carbon removal: Integrating technical potential with environmental, social, governance criteria, and sequestration permanence.

Climate modeling suggests that achieving international climate goals requires a reduction in current CO emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation, conducted by ENGIE's scientific council using an interdisciplinary Delphi panel methodology, proposes a "quality" measure for each technology.

Insights from multiple stable isotopes (C, N, Cl) into the photodegradation of herbicides atrazine and metolachlor.

Many processes can contribute to the attenuation of the frequently detected and toxic herbicides atrazine and metolachlor in surface water, including photodegradation. Multi-element compound-specific isotope analysis has the potential to decipher between these different degradation pathways as Cl is a promising tool for both pathway identification and a sensitive indicator of degradation for both atrazine and metolachlor. In this study, photodegradation experiments of atrazine and metolachlor were conducted under simulated sunlight in buffered solutions (direct photodegradation) and with nitrate (indirect photodegradation by OH radicals) to determine kinetics, transformation products and isotope fractionation for C, N and for the first time Cl.

Understanding the Needs and Experiences With Health Services of Gay and Bisexual Men (GBM) Who Engaged in Chemsex During the First Year of the COVID-19 Pandemic in Quebec, Canada.

Gay and bisexual men (GBM) engaging in chemsex can face various health and well-being-related challenges, the extent of which remains unknown given the limited research in the context of the COVID-19 pandemic. This paper examines the pandemic impacts on the health needs of GBM who engaged in chemsex and their experiences with related services. We applied interpretive description to produce knowledge with direct implications for improving practices and policies.

Integration of functional electrical stimulation during robotic-assisted intervention to increase bone mineral density in individuals with complete spinal cord injury: case report.

Introduction: A spinal cord injury (SCI) leads to an alteration of the central nervous system which significantly impacts the health, function and quality of life of those affected. Since SCI leads to a loss lower limbs usage, sublesional osteoporosis is a common and established consequence with high risk of fracture in this population. The mechanical loading remains the most effective approach to stimulate physiologic bone remodeling.

Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults.

In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. We measured tau-PET in regions associated with Braak stages I to VI, global amyloid-PET burden, hippocampal subfield volumes and memory assessments from 173 participants aged 55-85. Eighty-six of these participants were tested again two years later.

Byproduct-to-Host Ratios for Assessing the Accessibility of Mineral Resources.

Mineral resources are essential for reaching net-zero ambitions by 2050. There is a rising diversity of metals in electricity generation and storage technologies, as well as for mobility technologies. However, little is known about the future supply of minor elements historically mined in low volumes such as indium, tellurium, germanium, or tantalum.

Mental disorder diagnoses and symptoms and functional impairment in school-age children in the care of child protective services.

Background: About 50 % of children in the care of child protective services present at least one mental disorder, but few studies have looked at whether there are differences in mental disorders or symptoms between children placed in out-of-home care (foster care and residential care) and their community peers.

Objective: This study documents the mental disorder diagnoses and symptoms among children in out-of-home care and their associations with children functional impairment. It also compares out-of-home care children with those from the community.

Simultaneous assessment of membrane bilayer structure and drug insertion by F solid-state NMR.

Fluorine-19 is an ideal nucleus for studying biological systems using NMR due to its rarity in biological environments and its favorable magnetic properties. In this work, we used a mixture of monofluorinated palmitic acids (PAs) as tracers to investigate the molecular interaction of the fluorinated drug rosuvastatin in model lipid membranes. More specifically, PAs labeled at the fourth and eighth carbon positions of their acyl chains were coincorporated in phospholipid bilayers to probe different depths of the hydrophobic core.

Interplay of socio-emotional vulnerability and physiological stress response: Unraveling distress patterns amidst the COVID-19 pandemic.

The COVID-19 pandemic led to increased internalizing symptoms (IS) among adults, with notable interindividual differences. Cross-sectional studies suggest that both biological (physiological stress) and psychological (socio-emotional) factors independently contribute to IS. This longitudinal study examined whether physiological stress during the pandemic moderated the relationship between socio-emotional vulnerability and IS.

Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment.

Rab7A has a key role in regulating membrane trafficking at late endosomes. By interacting with several different effectors, this small GTPase controls late endosome mobility, orchestrates fusion events between late endosomes and lysosomes, and participates in the formation of and regulates the fusion between autophagosomes and lysosomes. Rab7A is also responsible for the spatiotemporal recruitment of retromer, which is required for the endosome-to-trans-Golgi network retrieval of cargo receptors such as sortilin (SORT1) and CI-MPR (also known as IGF2R).

A Roadmap of Noninstitutional Living Options for People with Dementia: "Don't Fence Me In".

Canadians overwhelmingly do not want to live in long-term care institutions (LTCIs) when they age; yet many end up there for lack of home care, because family care partners burn out, or because they and their professional advisors are unaware of alternatives to institutions. Not only is institutional dementia care riven with problems, it segregates disabled people, thereby abrogating human rights. Because systemic ageism and ableism cloud seniors' care, institutions remain the default option for Canadians with dementia.

Validation of a laboratory spray generation system and its use in a comparative study of hexamethylene diisocyanate (HDI) evaluation methods.

Isocyanates are well-known irritants and sensitizers, and measuring their occupational airborne exposure is challenging due to their high chemical reactivity and semi-volatile nature. This study builds on a previous publication by our team that focused on comparing evaluation methods for isocyanates. The current research aims at developing, validating, and applying a laboratory generation system designed to replicate real-world conditions for spraying clear coats in autobody shops using hexamethylene diisocyanate (HDI)-based products.

"It's someone who means a lot to me, and who means even more to mom": Children's views on the romantic partners of their polyamorous parents.

Polyamory is a relationship style that allows individuals to develop multiple romantic relationships simultaneously. Although studies show that many polyamorous people have children, very little is known about the experiences of children growing up in such a family context. Based on 18 semi-structured interviews with Canadian children living with polyamorous parents, we examined the level of emotional closeness they felt towards their parents' romantic partners, and what these adults meant to them.