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Abnormal brain function in photophobic patients with dry eye disease: An fMRI study.
Rev Neurol (Paris)
June 2023
Inserm U 1127, CNRS UMR 7225, Sorbonne universités, UPMC University of Paris 06 UMR S 1127, Institut du cerveau, ICM, 75013 Paris, France; Hôpital de la Pitié Salpêtrière, Féderation de neurologie, AP-HP, 75013 Paris, France. Electronic address:
Background And Objectives: Photophobia, a frequent and disabling symptom observed in various neurological conditions and eye diseases, is thought to involve maladaptive brain functioning. We assessed this hypothesis, using functional magnetic resonance imaging (fMRI) in photophobic patients with minimal-to-severe dry eye disease (DED), as compared to healthy controls.
Methods: This prospective, monocentric, comparative, cohort study included eleven photophobic DED patients compared to eight controls.