433 results match your criteria: "UPMC Eye Center[Affiliation]"
J AAPOS
December 2021
UPMC Children's Hospital of Pittsburgh, Pediatric Ophthalmology, Strabismus, and Adult Motility, Pittsburgh, Pennsylvania; UPMC Eye Center, Pittsburgh, Pennsylvania; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:
Purpose: To describe the efficacy and systemic side effects of apraclonidine drops 0.5% in children clinically suspected of having Horner syndrome.
Methods: The medical records of patients with clinically suspected Horner syndrome who underwent testing with apraclonidine 0.
J Chromatogr B Analyt Technol Biomed Life Sci
November 2021
Schepens Eye Research Institute of Massachusetts Eye & Ear, Dept. of Ophthalmology, Harvard Medical School, Boston, MA, United States. Electronic address:
Besifloxacin has been embraced for the treatment of ocular bacterial infections. While LC-MS/MS has been used in investigating BSF pharmacokinetics, those costly instruments are not universally available and have complicated requirements for operation and maintenance. Additionally, pharmacokinetics of besifloxacin in dose-intense regimens are still unknown.
View Article and Find Full Text PDFJ Cataract Refract Surg
July 2022
From the Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China (Cao, Zhang, Liang, Li, Wang), the Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Tianjin, China (Zhang, Wang), the UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (Jhanji).
Purpose: To determine the long-term clinical outcomes and change in posterior corneal elevation after small-incision lenticule extraction (SMILE) in eyes with suspicious tomographic features.
Setting: Hospital clinic.
Design: Retrospective, case-controlled, observational.
Graefes Arch Clin Exp Ophthalmol
April 2022
Ophtalmopole, Cochin Hospital, University of Paris, Paris, France.
Purpose: Validation of a recently described central serous chorioretinopathy (CSCR) classification system and assessment of levels of agreement among 10 retina physicians.
Methods: This was a cross-sectional (inter-reader agreement) study. Ten retina physicians (assigned a role of masked grader) were provided with a comprehensive dataset of 61 eyes of 34 patients of presumed CSCR.
Int J Retina Vitreous
October 2021
Centre Hospitalier Intercommunal de Creteil, Paris, France.
Background: Subthreshold microsecond pulsing laser is an increasingly common treatment approach for central serous chorioretinopathy. However, there is no literature available on the safety of microsecond laser using different fluence settings in this disease. While many publications can be obtained from conventional microsecond pulsing lasers, few parameter sets are published with the navigated microsecond pulsing laser.
View Article and Find Full Text PDFEye (Lond)
May 2022
UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.
Fluorescein and indocyanine green angiography have been the traditional ways to image the vasculature of the iris in the last few decades. Because of the invasive nature of these procedures, they are performed in rare situations, and thus, our understanding about iris vasculature is very limited. Optical coherence tomography angiography (OCTA) is a noninvasive imaging method that enables the detailed visualization of the retinal and choroidal vascular networks.
View Article and Find Full Text PDFEye (Lond)
March 2022
UPMC Eye Center, University of Pittsburgh, Pittsburgh, USA.
Objective: To evaluate visual acuity (VA) and factors influencing VA using new multimodal imaging-based classification of central serous chorioretinopathy (CSCR).
Methods: Retrospective, observational and cross-sectional study on 229 naïve eyes diagnosed as CSCR with available baseline data and multimodal imaging. Each case was classified into (i) simple/complex/atypical; (ii) primary/recurrent/resolved; (iii) persistent or not; (iv) outer retinal atrophy(ORA) present/absent; (v) foveal involvement present/absent; and (vi) macular neovascularization(MNV) present/absent.
Graefes Arch Clin Exp Ophthalmol
April 2022
Department of Ophthalmology, University of Pittsburgh Eye and Ear Institute, Pittsburgh, PA, USA.
Purpose: To assess the influence of fellow eye information on diagnosis and classification of central serous chorioretinopathy (CSCR) using multimodal imaging-based classification.
Methods: This was a retrospective, observational study including patients with CSCR with unilateral or bilateral involvement. Multimodal images of both eyes of each patient were compiled and presented to two masked retina specialists subdivided into three groups: (1) both eye data, (2) right eye data and (3) left eye data.
Purpose: Peters-plus syndrome is a rare, autosomal recessive congenital disorder of glycosylation caused by mutations in the gene B3GLCT. A detailed description of the ocular findings is currently lacking in the scientific literature. We report a case series of Peters-plus syndrome with deep ocular phenotyping using anterior segment optical coherence tomography and ultrasound biomicroscopy.
View Article and Find Full Text PDFInt Ophthalmol
February 2022
University of Pittsburgh, UPMC Eye Center, 203 Lothrop Street, Pittsburgh, PA, 15213, USA.
Purpose: To study interocular asymmetry in distribution of leaks in central serous chorioretinopathy (CSC).
Material And Methods: Patients with unilateral CSC were included in this retrospective multicenter study. All patients received multimodal imaging.
J Agric Food Chem
October 2021
Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou 515041, Guangdong, China.
Pterygium belongs to an ocular surface disease with triangular-shaped hyperplastic growth, characterized by conjunctivalization, inflammation, and connective tissue remodeling. We previously demonstrated neoplastic-like properties of pterygium cells. Green tea catechin, (-)-epigallocatechin gallate (EGCG), has been shown to possess antitumorigenic properties; herein, we aimed to determine the effects of green tea catechins on human primary pterygium cell survival and migration and compared to that on patients' conjunctival cells.
View Article and Find Full Text PDFRetina
October 2021
Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, Louisiana Jolla, California.
Purpose: To determine structural predictors of treatment response in neovascular age-related macular degeneration analyzing optical coherence tomography (OCT)-related biomarkers.
Methods: A retrospective review of patients undergoing treatment for neovascular age-related macular degeneration at a tertiary institute was performed at presentation. High-intensity regimen included eyes on long-term anti-vascular endothelial growth factor treatment with the inability to extend beyond a month without a relapse and needed double the dose of medication (n = 25).
Semin Ophthalmol
April 2022
University of Pittsburgh, UPMC Eye Center, Pittsburgh, PA, USA.
Optical coherence tomography (OCT) is widely applied in diagnosis and management of retina diseases particularly macular diseases in adult retina practices. However, it has been under-utilized in pediatric retinal diseases especially in neonates and infants. Utilization of OCT in primary macular diseases in this age group is also uncommon and is less reported.
View Article and Find Full Text PDFActa Ophthalmol
June 2022
Department of Medicine and Surgery, Section of Ophthalmology, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
Purpose: To compare the 12 months visual and anatomical outcomes of treatment-naïve neovascular age-related macular degeneration (nAMD) patients diagnosed by optical coherence tomography angiography (OCT-A) compared with fluorescein angiography (FA)/indocyanine green angiography (ICGA), after anti-VEGF treatment in a real-world setting.
Methods: Monocentric, observational, parallel-group study of nAMD patients diagnosed with either FA/ICGA or non-invasive OCT-A methods. Patients were treated with a fixed dosing regimen of intravitreal ranibizumab or aflibercept and followed up for 12 months.
Expert Opin Drug Deliv
November 2021
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Introduction: Retinal disease treatment delivery is mostly limited to intravitreal injections and slow-release injectable implants due to structural barriers in the eye, and carry associated adverse effects and relatively high treatment burden. The Port Delivery System with ranibizumab (PDS) is a novel drug delivery device that is surgically implanted into the vitreous cavity and allows for continuous release of the anti-vascular endothelial growth factor (anti-VEGF) ranibizumab, eliminating the need for frequent intravitreal injections while maintaining therapeutic intraocular drug levels to control disease activity. Investigations of PDS are summarized in this review.
View Article and Find Full Text PDFOphthalmol Retina
August 2021
UPMC Eye Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Eur J Ophthalmol
July 2022
UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.
Background/objectives: To evaluate the presence and evolution of fluid in non-exudative age-related macular degeneration (AMD) through serial OCT.
Subjects/methods: A retrospective analysis of eyes with non-exudative AMD with a minimum of 4 year follow-up was done. Parameters including intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid (SRPEF); subfoveal choroidal thickness (SFCT) and type of drusen were evaluated using optical coherence tomography (OCT) scans at baseline and follow up visits.
Eur J Ophthalmol
May 2022
UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Age-related macular degeneration (AMD) is one of the leading causes of blindness with loss of retinal layers over long term. We aim to evaluate these changes in eyes with progressive non-exudative AMD with geographic atrophy (GA).
Methods: This retrospective study included patients with GA with a minimum of 4 years follow up.
Molecules
June 2021
The Charles T. Campbell Ophthalmic Microbiology Laboratory, UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
There is no approved antiviral therapy for adenovirus (HAdV) ocular infections. Astodrimer sodium (SPL7013) is a polyanionic dendrimer with antiviral activity. The current study evaluated the ocular tolerability and anti-adenoviral efficacy of topical SPL7013 in rabbit ocular models.
View Article and Find Full Text PDFSurv Ophthalmol
March 2022
University of Pittsburgh, UPMC Eye Center, Pittsburgh, PA, USA. Electronic address:
Sildenafil citrate, a selective oral phosphodiesterase 5 inhibitor, is a widely used drug for erectile dysfunction that acts by elevating cGMP levels and causing smooth muscle relaxation. It also has 10% activity against PDE6, a key enzyme in phototransduction cascade in the retina. Recent ocular imaging developments have further revealed the influence of sildenafil on ocular hemodynamics, particularly choroidal perfusion.
View Article and Find Full Text PDFOphthalmic Genet
October 2021
Division of Pediatric Ophthalmology, Strabismus, and Adult Motility, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
: Congenital Stationary Night Blindness (CSNB) is a clinically and genetically heterogenous inherited retinal disorder associated with nystagmus, myopia, strabismus, defective dark adaptation, and decreased vision. Pathogenic variants in at least 17 genes have been associated with CSNB, where a hemizygous variant of causing an X-linked form of the disorder is among the commonest causes.: A retrospective chart review of a single pedigree was performed.
View Article and Find Full Text PDFCurr Phys Med Rehabil Rep
June 2021
Centers for Rehab Services (CRS), UPMC Eye Center Eye and Ear Institute, Low Vision Occupational Therapy Department, University of Pittsburgh Medical Center (UPMC), 7th Floor,Room 745, 203 Lothrop St, Pittsburgh, PA 15213 USA.
Purpose Of Review: Currently, a lack of guidelines exists regarding best practices for occupational therapists (OTs) in the treatment and evaluation of oculomotor dysfunction following traumatic brain injury (TBI). Furthermore, individuals with TBI would benefit significantly from collaboration between OTs and optometrists during inpatient rehab.
Recent Findings: Although few articles examine interdisciplinary models of inpatient rehab care that include optometry, a recent pilot study is explored.
Surv Ophthalmol
March 2022
UPMC Eye Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:
Newer anticancer drugs have revolutionized cancer treatment in the last decade, but conventional chemotherapy still occupies a central position in many cancers, with combination therapy and newer methods of delivery increasing their efficacy while minimizing toxicities. We discuss the retinal toxicities of anticancer drugs with an emphasis on the mechanism of toxicity. Uveitis is seen with the use of v-raf murine sarcoma viral oncogene homolog B editing anticancer inhibitors as well as immunotherapy.
View Article and Find Full Text PDFProg Retin Eye Res
January 2022
Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland. Electronic address:
In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal vascular hyperpermeability, but the etiology for the fluid is controversial. The choroidal vascular findings as elucidated by recent optical coherence tomography (OCT) and wide-field indocyanine green (ICG) angiographic evaluation show eyes with CSC have many of the same venous patterns that are found in eyes following occlusion of the vortex veins or carotid cavernous sinus fistulas (CCSF).
View Article and Find Full Text PDFSemin Ophthalmol
January 2022
UPMC Eye Center, University of Pittsburgh, Pittsburgh, USA.
Purpose: Vitrectomy with brilliant blue G (BBG) assisted internal limiting membrane (ILM) peeling is the standard operational technique in macular hole surgeries. However, BBG dye, though considered safe and nontoxic, can also occasionally lead to macular toxicity. This study aims to describe the clinical features and characteristics of four eyes who developed macular toxicity after following surgery for macular hole repair.
View Article and Find Full Text PDF