433 results match your criteria: "UPMC Eye Center[Affiliation]"

Pentosan polysulfate sodium maculopathy: Final analysis of a prospective cohort, updated review, and association with inflammatory bowel disease.

Surv Ophthalmol

December 2024

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, CA; Greater Los Angeles VA Healthcare Center (D.S.), Los Angeles, California, USA. Electronic address:

Pentosan polysulfate sodium (PPS) maculopathy is a recently described condition of macular toxicity. We report the prevalence (15%), the clinical characteristics, and the multimodal imaging (MMI) features of PPS maculopathy based on a final prospective analysis of a cohort of 154 subjects and highlight the association with inflammatory bowel disease (IBD). In addition, we summarize the most recent and relevant literature on PPS maculopathy.

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Article Synopsis
  • The study investigated choroidal vascular responses in chronic central serous chorioretinopathy (CSCR) patients using optical coherence tomography (OCT) during temporary blood pressure increases from physical stress.
  • It compared CSCR patients with age-matched healthy individuals, measuring parameters like mean ocular perfusion pressure (MOPP) and choroidal thickness at rest and during hand-grip exercises.
  • Results showed CSCR patients had higher MOPP and choroidal thickness compared to controls, but unlike healthy subjects, they did not exhibit a vasoconstrictive response to stress, indicating possible impairment in their choroidal blood flow regulation.
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Purpose: To analyze the efficacy and safety of microsecond pulsing laser therapy (MLT) in the management of central serous chorioretinopathy (CSCR) complicated by choroidal neovascularization (CNV).

Methods: Patients with CSCR complicated by CNV defined as the presence of characteristic OCT angiography features were randomly assigned to either study or control group. All patients of the study group underwent MLT targeting CNV area using navigated laser system followed by at least 6-month follow-up.

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Objectives: We aimed to investigate choroidal involvement and the degree of anterior chamber inflammation in a cohort of patients with juvenile idiopathic arthritis (JIA) without clinical signs of active uveitis and to compare it with healthy controls (HC).

Methods: Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 21 patients diagnosed with JIA and 22 HC of equal age were acquired. Images were binarised to measure subfoveal choroidal thickness (SCT), nasal choroidal thickness (NCT), temporal choroidal thickness (TCT), total choroidal area (TCA), luminal area (LA), stromal area (SA) and choroidal vascular index (CVI).

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Article Synopsis
  • - The study focused on analyzing the differences in treatment plans for diabetic macular edema and central serous chorioretinopathy among 25 retina specialists using diagnostic images from 20 patients.
  • - Key metrics for evaluating the treatment plans included Area Variability (AV), which measures consensus on the treatment area, and Centroid Distance (CD), which assesses agreement on treatment localization.
  • - Results indicated that while specialists generally preferred targeted treatments and avoided the subfoveal region, there was significant variability in planning that decreased with the specialists' experience, showing that less experienced specialists had broader variability in coverage areas.
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Background: Large language models (LLMs) such as ChatGPT-4 and Google Gemini show potential for patient health education, but concerns about their accuracy require careful evaluation. This study evaluates the readability and accuracy of ChatGPT-4 and Google Gemini in answering questions about retinal detachment.

Methods: Comparative study analyzing responses from ChatGPT-4 and Google Gemini to 13 retinal detachment questions, categorized by difficulty levels (D1, D2, D3).

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In the last decade, artificial intelligence (AI) has significantly impacted ophthalmology, particularly in managing corneal diseases, a major reversible cause of blindness. This review explores AI's transformative role in the corneal subspecialty, which has adopted advanced technology for superior clinical judgment, early diagnosis, and personalized therapy. While AI's role in anterior segment diseases is less documented compared to glaucoma and retinal pathologies, this review highlights its integration into corneal diagnostics through imaging techniques like slit-lamp biomicroscopy, anterior segment optical coherence tomography (AS-OCT), and in vivo confocal biomicroscopy.

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Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-Associated X-Linked Retinitis Pigmentosa.

Am J Ophthalmol

November 2024

From the UCL Institute of Ophthalmology (M.M., Y.Y., T.A.C.G., S.C.W., J.J.L.T., A.K., M.G., A.J.S., R.R.A., J.B.), London, UK; Moorfields Eye Hospital NHS Foundation Trust (M.M., Y.Y., T.A.C.G., S.C.W., J.J.L.T., N.K., A.K., M.G., J.B.), London, UK.

Purpose: To assess the safety and efficacy of AAV5-hRKp.RPGR in participants with retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (XLRP).

Design: Open-label, phase 1/2 dose escalation/expansion study (ClinicalTrials.

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Purpose was to study 3-dimensional choroidal contour at choroidal inner boundary (CIB) and choroidal outer boundary (COB) in healthy eyes. Healthy eyes imaged on wide field swept-source optical coherence tomography were included. Delineation of CIB and COB was done based on our previously reported methods.

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Purpose: To evaluate the efficacy and safety of photodynamic therapy (PDT) with chlorin E6 in chronic central serous chorioretinopathy.

Methods: In this single-center retrospective cohort study, all patients received standard PDT with 6 mg of chlorin E6 (Fotoran E6) for each m 2 of body surface area with 50 J/cm 2 fluence and a treatment time of 83 seconds. The changes in central retinal thickness, subfoveal choroidal thickness, and best-corrected visual acuity were evaluated at the end of the follow-up.

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Purpose: To describe a potential biomarker termed as inner choroidal fibrosis in cases of chronic central serous chorioretinopathy (CSCR) presenting to a tertiary referral center.

Design: Observational case series.

Methods: Five eyes of 4 patients with CSCR were noted to have a gray-white subretinal lesion in the macula, which was analyzed with multimodal imaging.

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Artificial intelligence (AI)- and deep learning (DL)-based systems have shown significant progress in the field of macular disorders, demonstrating high performance in detecting retinal fluid and assessing anatomical changes during disease progression. This study aimed to validate an AI algorithm for identifying and quantifying prognostic factors in visual recovery after macular hole (MH) surgery by analyzing major optical coherence tomography (OCT) biomarkers. This study included 20 patients who underwent vitrectomy for a full-thickness macular hole (FTMH).

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Peripapillary fluid: Obvious and not so obvious!

Surv Ophthalmol

April 2024

University of Pittsburgh, UPMC Eye Center, Pittsburgh, United States. Electronic address:

Intraretinal or subretinal fluid in the peripapillary area can be clinically visualized in conditions such as peripapillary choroidal neovascularization, optic disc pit maculopathy, and optic nerve head tumors and granulomas. Optical coherence tomography (OCT) helps to visualize peripapillary fluid in many other chorioretinal conditions such as peripapillary pachychoroid syndrome, posterior uveitis, central retinal vein occlusion, malignant hypertension, hypotonic maculopathy as well as neuro-ophthalmological conditions such as glaucoma, microcystic macular edema and disc edema due papilledema, non-arteritic anterior ischemic optic neuropathy, neuroretinitis, and diabetic papillopathy. Often, the differential diagnosis of peripapillary fluid is a bit tricky and may lead to misdiagnosis and improper management.

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Purpose: To report the emergence and progress of four late-stage characteristics: incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA), drusen ooze and drusen collapse in eyes with dry age-related macular degeneration (AMD) using Spectral Domain Optical Coherence Tomography (SD-OCT).

Methods: This was a retrospective analysis of eyes with non-exudative AMD. Multimodal imaging was done at follow up visits ≤ 12 months.

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Article Synopsis
  • Posterior uveitis is an eye condition that can affect anyone and is often a reason people visit eye doctors.
  • It can be caused by infections, autoimmune diseases, and some conditions that look like uveitis but aren’t really it, which makes it tricky to diagnose.
  • This study looked at different types of uveitis and their confusing similarities to other diseases to help doctors better recognize and treat these eye problems.
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Background: A number of articles report the association of polypoidal lesions and choroidal nevi; however, the relationship between choroidal nevi and pachychoroidal disorders has not been studied.

Objectives: To study the prevalence of choroidal nevi in central serous chorioretinopathy (CSCR) patients and to elucidate potential differences in the clinical characteristics of CSCR in patients with and without choroidal nevi.

Design: Case-control study.

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Pediatric oral fluorescein angiography: a retrospective review from a single institution.

J AAPOS

August 2023

University of Pittsburgh Medical Center (UPMC) Eye Center and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Children's Hospital of Pittsburgh of UPMC Division of Pediatric Ophthalmology Strabismus and Adult Motility, Pittsburgh, Pennsylvania; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

Article Synopsis
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New insights on circumscribed choroidal hemangioma: "bench to bedside".

Graefes Arch Clin Exp Ophthalmol

April 2024

Eye Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.

Circumscribed choroidal hemangioma is a rare vascular hamartoma of the choroid, presenting as a red-orange mass at the posterior pole on fundoscopic examination. Despite its benign origin, associated complications such as subretinal fluid, serous retinal detachment, retinoschisis and neovascular glaucoma may lead to serious visual impairment in more than half patients. Because of its similarity to amelanotic choroidal melanoma and choroidal metastasis, differential diagnosis is still challenging for specialists.

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Central serous chorioretinopathy (CSCR), first described by Albrecht von Graefe in 1866, is characterized by focal serous detachment of the neural retina and/or retinal pigment epithelium (RPE) in the posterior pole. CSCR is the first ever described pachychoroid disease. Most recently, hypothetical venous overload choroidopathy is also proposed due to its distinguished morphological and pathological characteristics, including choroidal thickening, choriocapillaris hyperpermeability, remodelling, and intervortex venous anastomoses.

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 We assess the clinical accuracy of direct-to-patient real-time outpatient video visit encounters at our eye center.  This was a retrospective longitudinal study.  Patients who completed a video visit over a 3-week period between March and April 2020 were included.

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Purpose: To evaluate the impact of drusen-like deposits (DLD) on retinal layer integrity and retinal function by optical coherence tomography (OCT) and multifocal electroretinography (mfERG) in patients with systemic lupus erythematosus (SLE).

Methods: We identified 66 eyes of 33 SLE patients treated with hydroxychloroquine (HCQ) that were categorized into two groups according to whether DLDs were present (34 eyes, Group One) or absent (32 eyes, Group Two). The groups were matched for age, sex, HCQ treatment duration, daily, and cumulative dosage.

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The ideal intravitreal injection setting: office, ambulatory surgery room or operating theatre? A narrative review and international survey.

Graefes Arch Clin Exp Ophthalmol

November 2023

Department of Medicine - Ophthalmology, University of Udine, Piazzale Santa Maria Della Misericordia, 33100, Udine, Italy.

Article Synopsis
  • This study looks at the best places to give injections of a medicine called VEGF inhibitors, which help treat eye problems.
  • Researchers checked rules from 23 countries, surveyed clinics, and reviewed a lot of old research to find out where these injections are given and how safe they are.
  • They found that giving injections in different places, like offices or hospitals, doesn't really change the chances of complications, so it’s important to pick the right spot to help manage patients better.
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