5 results match your criteria: "UPMC (Pierre and Marie Curie University[Affiliation]"
Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.
Circ Genom Precis Med
October 2018
Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.
Background: In pulmonary arterial hypertension (PAH), pathological changes in pulmonary arterioles progressively raise pulmonary artery pressure and increase pulmonary vascular resistance, leading to right heart failure and high mortality rates. Recently, the first potassium channelopathy in PAH, because of mutations in KCNK3, was identified as a genetic cause and pharmacological target.
Methods: Exome sequencing was performed to identify novel genes in a cohort of 99 pediatric and 134 adult-onset group I PAH patients.
Severe masseter spasms in a Rett syndrome during rapid sequence intubation: A succinylcholine severe side effect.
Indian J Crit Care Med
September 2015
Paediatric Intensive Care Unit, Armand-Trousseau Hospital, Paris Hospitals, Public Assistance, UPMC (Pierre and Marie Curie University), Paris VI, Paris, France.
Calcium homeostasis disorder during and after neonatal extracorporeal membrane oxygenation.
Indian J Crit Care Med
September 2015
Paediatric Intensive Care Unit, Armand-Trousseau Hospital APHP (Paris Hospitals Public Assistance), UPMC (Pierre and Marie Curie University, Paris VI), Paris, France.
Background And Aims: Extracorporeal membrane oxygenation (ECMO) is used during pediatric resuscitation in case of refractory hypoxemia or septic shock under maximum therapy. Previous studies describe calcium homeostasis dysregulation. The aim of this study was to confirmed of calcium homeostasis dysregulation in neonates under ECMO and supposed news explanation.
View Article and Find Full Text PDFDopa-decarboxylase gene polymorphisms affect the motor response to L-dopa in Parkinson's disease.
Parkinsonism Relat Disord
February 2014
INSERM (French National Institute of Medical Research and Health), APHP (Assistance Publique Hopitaux de Paris), Clinical Investigation Center (CIC-9503), Pitié-Salpêtrière Hospital, Paris, France; INSERM, UMRS_975 unit, UPMC (Pierre and Marie Curie University), CNRS UMR7525 CR-ICM, Paris, France; APHP, Pitié-Salpêtrière Hospital, Department of Neurology, France.
Article Synopsis
- The study investigates how genetic variations in the DDC gene influence the motor response to L-dopa in Parkinson's disease patients.
- Results show that those with certain DDC gene polymorphisms exhibit a significantly reduced motor response to L-dopa compared to other genotypes, regardless of L-dopa dosages.
- The findings suggest that while these genetic variations affect motor response, they do not alter the pharmacokinetics of L-dopa and dopamine in the body.
A pilot study comparing two polymethylpentene extracorporeal membrane oxygenators.
Perfusion
January 2013
Paediatric Intensive Care Unit, Armand-Trousseau Children's Hospital APHP (Paris Hospitals Public Assistance) UPMC (Pierre and Marie Curie University, Paris VI) Paris, France.
Objective: We compared two polymethylpentene oxygenators being used in our unit: the Maquet Quadrox-iD paediatric and the Medos Hilite 800LT.
Study Design: A mono-centric, prospective pilot study was conducted on ten consecutive newborn patients who had been admitted to our hospital service for extracorporeal circulation (EC) treatment. We examined the rate of oxygen transfer, the CO2 removal capacity and the average sweep gas flow required to produce this result.