6,597 results match your criteria: "UNIVERSITY OF THE WEST INDIES[Affiliation]"

Article Synopsis
  • This systematic review and meta-analysis investigates the effectiveness and safety of rituximab (RTX) for treating idiopathic inflammatory myositis (IIM) by analyzing multiple studies through a systematic search of PubMed and Embase.
  • Seventeen studies involving 362 patients were included, revealing an overall response rate of 70%, with complete remission in 13% and partial response in 48%, indicating significant variation among different myositis types.
  • While RTX shows promise for IIM treatment, the notable side effects, including infusion reactions and infections, underscore the necessity for careful patient monitoring and further controlled trials to better understand long-term effects and establish treatment protocols.
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A global survey of telemedicine use in epilepsy care - practices before, during and after the COVID-19 pandemic.

Seizure

December 2024

Programme of Developmental Neurosciences, University College London National Institute for Health Research Biomedical Research Centre Great Ormond Street Institute of Child Health, Great Ormond Street Hospital for Children, and Young Epilepsy Lingfield, London, UK.

Article Synopsis
  • Telemedicine became a popular option for epilepsy care during the COVID-19 pandemic, offering effective and quality care beyond just preventing virus transmission.
  • A survey conducted from June to October 2023 gathered responses from 285 participants across 60 countries, showing a significant rise in telemedicine usage during the pandemic but a decrease afterward, especially in terms of reimbursement and regulations.
  • While telemedicine usage and acceptance have improved, issues like reimbursement, regulations, and patient privacy need to be addressed for better implementation in the future.
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The molecular coordination of tuberization: Current status and future directions.

Curr Opin Plant Biol

December 2024

The Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.

The integration of bulk transcriptomic, proteomic, and genomic data generated from numerous systems biology studies of tuberizing plants has resulted in a better understanding of the molecular and morphological aspects of tuberization. The identified conserved integrated hormonal, transcriptional, and metabolic pathways of tuberization in crops from various plant lineages support the hypothesis of a fundamental tuberization process. However, further studies are required to specify the additional processes defined by the genomics and phylogeny of the particular plant lineages, which control the morphological diversity of tubers.

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Article Synopsis
  • The blood transfusion service is crucial for public health, yet many Caribbean countries face a shortfall in blood supply to meet healthcare demands.
  • Understanding what motivates and hinders potential blood donors is key to increasing voluntary non-remunerated blood donations (VNRD) as recommended by the WHO.
  • A systematic review of research found that VNRD is uncommon in the region, with barriers including lack of a known recipient and fears related to donation; however, increased information about the importance of blood donation could encourage more people to participate.
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This study examined a model of the associations among self-esteem, body dissatisfaction, and the drive for muscularity among Jamaican male weight lifters, and compared model relationships between weight lifters from rural and urban areas of residence. Using a purposive sampling approach, cross-sectional data were collected from 225 male weight lifters, ages 18-67 years ( = 28.16,  = 9.

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Mapping the global neurosurgery workforce. Part 2: Trainee density.

J Neurosurg

July 2024

2Department of Global Health and Social Medicine, Program for Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts.

Article Synopsis
  • The study aimed to analyze the global neurosurgery training workforce, focusing on the types of training programs, trainee support, diversity of experiences, and accreditation processes.
  • Data were collected from 187 countries and 25 territories, revealing an estimated 1,261 training programs and over 10,500 trainees, with significant variations in density based on country income levels and WHO regions.
  • High-income countries had a much higher density of trainees (0.48 per 100,000 people) compared to lower-income countries, which faced challenges like limited subspecialty training and resources.
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Mapping the global neurosurgery workforce. Part 1: Consultant neurosurgeon density.

J Neurosurg

July 2024

2Department of Global Health and Social Medicine, Program for Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts.

Article Synopsis
  • The study aimed to assess the global distribution and growth of consultant neurosurgeons, especially in low- and middle-income countries, to understand the impact of efforts to expand access to neurosurgery worldwide.
  • A comprehensive electronic survey was conducted across 192 countries and 25 territories, revealing an estimated 72,967 neurosurgeons, with a global density of 0.93 per 100,000 people, and significant variation by income level.
  • Findings indicated that neurosurgeon density increases with national income level, highlighting the shortage in low-income areas, particularly in WHO African and Southeast Asia regions, while the Western Pacific region showed the highest density of neurosurgeons.
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Background: Standard irrigating protocols during root canal treatment call for the use of sodium hypochlorite during chemo-mechanical preparation, followed by final irrigation with ethylenediaminetetraacetic acid (EDTA). This study determined the effectiveness of a new irrigant, Triton (Brasseler, USA), on smear layer removal during root canal treatment compared to that of 5.25% sodium hypochlorite and CanalPro EDTA 17% (Coltene).

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This scoping review assessed the surgical backlog in Latin America and the Caribbean (LAC) due to COVID-19 and identified mitigation strategies. We searched seven databases for citations from December 2019 to December 2022, focusing on LAC patients with cancelled or postponed procedures. We registered our protocol at Open Science Framework (https://osf.

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The coffee berry borer (CBB) Hypothenemus hampei was first described in Africa in 1867 and has spread to all major coffee-producing regions worldwide, including Jamaica. Using long-read sequencing, we produced a new high-quality reference genome (172.7 Mb) for the Jamaican strain of the CBB, with 93% of the genome assembled into 14 scaffolds.

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The need for effective primary healthcare to address social and structural determinants of health and to mitigate health inequalities has been well established. Here, we report on the international forum of the 2023 NAPCRG (formerly known as North American Primary Care Research Group) Annual Meeting. The aim of the forum was to develop principles for action for the primary healthcare research community on addressing social and structural determinants of health.

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Article Synopsis
  • The world is nearing the critical threshold of 1.5°C warming, with 2023 recording an average temperature rise of 1.45°C since pre-industrial times, leading to severe climate-related impacts.
  • The Countdown collaboration, formed to assess the health impacts of climate change post-Paris Agreement, involves over 300 experts analyzing data and trends annually.
  • The 2024 report highlights troubling increases in climate-related health risks, such as a staggering 167% rise in heat-related deaths among seniors, indicating worsening conditions affecting wellbeing globally.
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Draft genome of hydrocarbon-degrader BCTT, isolated from soil chronically polluted with crude oil in Trinidad.

Microbiol Resour Announc

December 2024

Biochemistry Research Lab (Rm216), Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.

BCTT isolated from chronically polluted soil in Trinidad, shows a capacity to survive in crude oil as a sole carbon source. Here, we report its high-quality draft genome sequence and highlight those pathways and genes involved in xenobiotic degradation. These data give a clearer insight into this organism's biotechnological potential.

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Caribbean health research has overwhelmingly employed measures developed elsewhere and rarely includes evaluation of psychometric properties. Established measures are important for research and practice. Particularly, measures of stress and coping are needed.

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During the COVID-19 pandemic, hypertensive patients had increased infection and healthcare disruption in many low- and middle-income countries (LMICs) with limited vaccine access. The objective of this report is to describe COVID-19 experiences and vaccination uptake among hypertensive patients in Colombia and Jamaica. A cross-sectional study of patients with hypertension was conducted in primary care clinics in both countries between 2021 and 2022.

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Implementation of Antigen-Based Diagnostic Assays for Detection of Histoplasmosis and Cryptococcosis among Patients with Advanced HIV in Trinidad and Tobago: A Cross-Sectional Study.

J Fungi (Basel)

October 2024

Department of Communicable Diseases Prevention, Control, and Elimination, Pan American Health Organization, Washington, DC 20037, USA.

The Caribbean continues to have high HIV prevalence globally with concurrently high mortality rates due to opportunistic Infections. This study addresses the prevalence of histoplasmosis and cryptococcosis among patients living with advanced HIV disease (AHD) in Trinidad and Tobago, focusing on the implementation of antigen-based diagnostic assays. Conducted as a cross-sectional survey across five HIV treatment sites, 199 participants with advanced HIV disease were enrolled between July 2022 and September 2023.

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Dengue and other arboviruses remain a global threat, and enhanced efforts to control the mosquitoes that transmit them are urgently needed. A survey of potential manmade (L.) and (Skuse) oviposition containers was performed in four communities near the end of the typical dry season in 2018 in Trinidad, West Indies.

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The Knowledge and Perceptions of Patient Safety and Patient Safety Culture During Dental Training: A Caribbean Perspective.

J Med Educ Curric Dev

October 2024

Unit of Restorative Dentistry, School of Dentistry, The University of the West Indies, Champs Fleurs, Trinidad, Trinidad and Tobago.

Article Synopsis
  • There is a lack of research on patient safety culture in dentistry, particularly in dental teaching hospitals.
  • The study aimed to explore the perceptions and knowledge of patient safety among clinical faculty, dental surgery assistants, and recent graduates at a Caribbean dental school using an anonymous online questionnaire.
  • Findings indicated a need for a patient safety curriculum, as participants perceived patient safety primarily through personal experience and saw it as largely driven by rules and policies, indicating clinical faculty have a significant role in ensuring patient safety.
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Objective: This cross-sectional study aims to assess the associations between serum leptin, adiponectin, leptin-to-adiponectin ratio (L/A ratio), and metabolic syndrome (MS) and HOMA-IR in five African-origin populations: Ghana, South Africa, Jamaica, Seychelles, and US.

Methods: Clinical measures included serum glucose, insulin, adipokines, blood pressure and anthropometric measures. MS was determined using the Harmonized criteria.

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Data on persons with perinatally acquired HIV infection in the Caribbean are limited; thus, a chart review was conducted among these clients at an adult HIV treatment clinic in Trinidad over the period January 01, 2011-June 30, 2023. Sociodemographic, clinical, and laboratory data were extracted and analyzed using RStudio version 2021.09.

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Article Synopsis
  • Exposure to toxic metals like lead and arsenic is linked to increased risks of obesity and type 2 diabetes (T2DM), but the exact mechanisms are still unclear.
  • A study analyzed the impacts of these metals on gut microbiota and cardiometabolic health in 178 adults of African descent, revealing significant associations between high metal levels and various health markers such as BMI and blood glucose.
  • The findings suggest that specific gut microbiome taxa are influenced by lead and arsenic exposure, potentially contributing to metabolic issues, particularly through pathways related to porphyrin metabolism.
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Motivation: Observational cohort studies that track vaccine and infection responses offer real-world data to inform pandemic policy. Translating biological hypotheses, such as whether different patterns of accumulated antigenic exposures confer differing antibody responses, into analysis code can be onerous, particularly when source data is dis-aggregated.

Results: The R package chronogram introduces the class chronogram, where metadata is seamlessly aggregated with sparse infection episode, clinical and laboratory data.

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Background: Achieving optimal immediate stability is crucial in lumbar fusion surgeries. Traditionally, four pedicle screws have been utilized to provide posterior stability at the L5-S1 level. However, the use of bilateral transfacet pedicle screws (TFPS) as an alternative construct has shown promising results in terms of biomechanical stability.

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