512 results match your criteria: "UNIVERSITY OF KENTUCKY COLLEGE OF ARTS AND SCIENCES.[Affiliation]"

Background: Although lifestyle factors have been linked to chronic diseases among adults, their association with diagnosed individual and comorbid cardiometabolic (CMD) and pulmonary disease (PD) is not fully known. This study aimed to examine the associations between lifestyle factors and individual and comorbid CMD and PD among U.S.

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Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e.

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Transcriptional Reprogramming Deploys a Compartmentalized 'Timebomb' in Catharanthus roseus to Fend Off Chewing Herbivores.

Plant Cell Environ

December 2024

Department of Plant and Soil Sciences and Kentucky Tobacco Research and Development Center, University of Kentucky, Lexington, Kentucky, USA.

The evolutionary arms race between plants and insects has led to key adaptive innovations that drive diversification. Alkaloids are well-documented anti-herbivory compounds in plant chemical defences, but how these specialized metabolites are allocated to cope with both biotic and abiotic stresses concomitantly is largely unknown. To examine how plants prioritize their metabolic resources responding to herbivory and cold, we integrated dietary toxicity bioassay in insects with co-expression analysis, hierarchical clustering, promoter assay, and protein-protein interaction in plants.

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Lifetime exposures to potentially psychologically traumatic events (PPTEs) among Royal Canadian Mounted Police (RCMP) cadets starting the Cadet Training Program (CTP) appear lower than exposures reported by serving RCMP, but the prevalence of PPTE exposures during the CTP remains unknown. The current study assessed PPTE exposures during the CTP and examined associations with mental disorders among RCMP cadets. Participants were cadets (n = 449, 24.

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TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury.

Acta Neuropathol

December 2024

Centre for Interdisciplinary Pain Medicine, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.

Nerve injury causes neuropathic pain and multilevel nerve barrier disruption. Nerve barriers consist of perineurial, endothelial and myelin barriers. So far, it is unclear whether resealing nerve barriers fosters pain resolution and recovery.

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Allostatic Load, Educational Attainment, and Risk of Cancer Mortality Among US Men.

JAMA Netw Open

December 2024

Center for Health Equity Transformation, Department of Behavioral Science, University of Kentucky, Lexington.

Importance: Health disparities among racial and ethnic minoritized populations, particularly for cancer mortality rates, remain a major public health concern. Men from underrepresented backgrounds (Black and Hispanic men, specifically) face the pervasive effects of discrimination in their daily lives, which also contribute to the complex associations among allostatic load (a marker of chronic stress), educational opportunities, and elevated risks of cancer mortality.

Objective: To elucidate the associations among educational attainment, allostatic load, and cancer mortality risk among men.

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Article Synopsis
  • The text discusses the importance of forecasting future health issues in the USA for effective planning and public awareness regarding disease and injury burdens.
  • It describes the methodology for predicting life expectancy, cause-specific mortality, and disability-adjusted life-years (DALYs) from 2022 to 2050 using the Global Burden of Diseases framework.
  • The forecasting includes various scenarios to assess the potential impacts of health risks and improvements across the country, focusing on demographic trends and health-related risk factors.
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  • The study investigates the surge of HIV cases in Scott County, Indiana, linked to the misuse of Opana ER, an opioid medication that replaced OxyContin due to its reformulation.
  • It analyzes pharmacy transaction data from 2007 to 2019, showing that Opana ER usage in Scott County skyrocketed after OxyContin's formula changed and peaked just before the HIV outbreak in 2014.
  • The findings suggest that the reformulation led to a significant drop in Opana ER transactions during the HIV outbreak, highlighting the importance of monitoring pharmaceutical sales to prevent drug misuse and related health crises.
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Purpose: Health care providers (HCP) are uniquely positioned to advise against electronic cigarette (e-cigarette) use, potentially influencing youth perceptions of e-cigarette harms. However, research examining these associations is scant. We examined whether HCP e-cigarette-related advice is associated with youth e-cigarette harm perceptions.

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Purpose: Persistent smoking after cancer diagnosis causes adverse outcomes while smoking cessation can improve survival. Thus, integration of smoking assessment and cessation assistance into routine cancer care is critical. Aiming for incremental practice change that could be sustained and built upon through future quality improvement (QI) projects, the American College of Surgeons initiated Just ASK in 2022 to increase implementation of smoking assessment among its accredited Cancer Programs.

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Influence of cocaine use reduction on markers of immune function.

J Neuroimmunol

December 2024

School of Human Development and Family Studies, Oregon State University, Waldo Hall 453, 2250 SW Jefferson Way, Corvallis, OR 97331, USA.

Article Synopsis
  • This study examined how reducing cocaine use affects the immune system in individuals with Cocaine Use Disorder.
  • Participants were divided into three groups based on the value of financial rewards they received for abstaining from cocaine, with the highest rewards leading to the most significant reductions in use.
  • The findings indicated that the group receiving high rewards not only reduced cocaine use significantly but also showed changes in immune markers, indicating an activated immune response that could reflect improved immune health.
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Background: Nesodiprion zhejiangensis, a multivoltine sawfly, is widely distributed in south China and has caused serious damage to forests. Historically, N. zhejiangensis management has relied heavily on synthetic chemicals.

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Objective: To determine pharmacy students' weekly work hours during Doctor of Pharmacy (PharmD) semesters, the primary reasons for working or not working, and how work hours impact their pharmacy education experience.

Methods: A multicenter cross-sectional survey was conducted among first-year (P1) to fourth-year (P4) pharmacy students enrolled in PharmD programs at 3 colleges of pharmacy between January and February 2024. The 22-item anonymous survey queried student characteristics, current and ideal paid work hours, primary reasons for working, and perceived consequences of work hours on pharmacy education.

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Article Synopsis
  • * Data from 900 incarcerated women with opioid use disorder were analyzed to identify individual, interpersonal, and community-level factors that help reduce the likelihood of high-risk behaviors.
  • * Results reveal key protective factors at multiple levels—such as age, relationship dynamics, and treatment experiences—that can inform targeted prevention strategies for different stages of substance use.
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Housing instability increases for stimulant-involved overdose deaths after linking surveillance data to electronic health records in Kentucky.

Drug Alcohol Depend

November 2024

Institute for Pharmaceutical Outcomes & Policy, Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, KY 40508, USA.

Article Synopsis
  • In 2022, 10.2% of fatal overdoses were linked to individuals facing homelessness or housing instability, with a growing concern over stimulant involvement in these overdoses in the U.S.
  • Researchers in Kentucky analyzed stimulant-involved fatal overdoses from 2017 to 2021, linking records from a drug overdose surveillance system to electronic health records to assess housing status.
  • Of the 313 overdose cases studied, initially only 10.5% were identified with housing instability, but after further data analysis, this figure rose to 41.5%, indicating that better data connections could enhance overdose surveillance and public health responses.
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Article Synopsis
  • * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
  • * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
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Examining use of telehealth in jails: linking women to community OUD services.

BMC Womens Health

October 2024

Center on Drug and Alcohol Research, University of Kentucky, 643 Maxwelton Court, Lexington, KY, 40506, USA.

Article Synopsis
  • Opioid use disorder (OUD) is a critical health issue for women, especially those in the criminal legal system, and this study explores how telehealth can link incarcerated women to medication-assisted treatment upon their release.
  • The research combines qualitative and quantitative methods to gather insights from treatment providers, recovery staff, and incarcerated women about the potential of telehealth in facilitating community services before release.
  • Results indicate strong support for telehealth, as it helps maintain clinical engagement and allows women to discuss sensitive issues, thus enhancing access to treatment for their substance use disorders.
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Article Synopsis
  • Healthcare providers play a crucial role in supporting smoking cessation efforts in primary care, yet only a portion of smokers show readiness to quit.
  • Among surveyed Appalachian primary care patients, 34.1% were current smokers, with 29.2% indicating readiness to quit within 6 months.
  • Despite a high percentage of providers inquiring about smoking and advising patients to quit, there is a gap in delivering comprehensive cessation support, highlighting the need for more intensive treatment strategies in these settings.
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  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Protocol for whole-mount immunostaining of brains of the eastern subterranean termite, Reticulitermes flavipes.

STAR Protoc

December 2024

Department of Entomology, School of Integrative Biology, College of Liberal Arts & Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

Immunostaining is a powerful technique for visualizing tissue morphology and protein expression patterns, but in non-model organisms, it may be impeded by a lack of established protocols. Here, we present a protocol for whole-mount immunostaining of termite brains that we applied to the termite Reticulitermes flavipes. We describe steps for brain dissection, fixation, staining, and mounting.

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Extensive social media use and frequency of current e-cigarette use among US youth.

Drug Alcohol Depend Rep

September 2024

Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.

Introduction: Both electronic cigarette (e-cigarette) and social media use among youth are public health concerns. While the health impacts of extensive social media use and frequent use of e-cigarettes have been discussed independently in the literature, little is known about the relationship between the two. This study aims to examine the potential association between extensive social media use and the frequency of current, e-cigarette use among United States (US) youth.

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Rationale: A recent study by our group found that women displayed greater attentional bias to alcohol-related cues during the late versus early follicular phase in both sober and intoxicated states, suggesting a greater risk of excessive drinking among women during this phase. Changes in attentional bias as a function of menstrual cycle phase raise questions about potential sex differences in the relative consistency by which women and men display attentional bias to alcohol over time.

Objectives: The present study tested sex differences in attentional bias to alcohol by comparing the change in women's attentional bias from early to late follicular phase to that observed in men over the same period.

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