Countering Coloniality in Global Health Comment on "The Rhetoric of Decolonizing Global Health Fails to Address the Reality of Settler Colonialism: Gaza as a Case in Point".

This commentary joins the chorus of rightful critiques of global health as it continues to further colonial agendas under the guise of supposed well-meaning efforts. Engebretsen and Baker rightfully call out the uptake of decolonial rhetoric in the field of global health, pointing out notable failures to actually challenge undergirding colonial structures and move beyond theory into meaningful action, using clear examples from the ongoing crisis in Gaza and global health's ongoing response (or lack thereof). In this work I bring together essential foundations of decolonial scholarship in order to further the work Engebretsen and Baker have defined as crucial reckoning points for the field of global health.

Barriers and facilitators for strengthening primary health systems for person-centred multimorbid care in low-income and middle-income countries: a scoping review.

Objective: To understand barriers and facilitators for strengthening health systems for person-centred care of people with multiple long-term conditions-multimorbidity (MLTC-M) at the primary healthcare (PHC) level in low-income and middle-income countries (LMICs).

Design: A scoping review.

Methods: We adopted a systematic scoping review approach to chart literature guided by Arksey and O'Malley's methodological framework.

Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses.

Hybrid incompatibilities are a critical component of species barriers and may arise due to negative interactions between divergent regulatory elements in parental species. We used a comparative approach to identify common themes in the regulatory phenotypes associated with hybrid male sterility in two divergent rodent crosses, dwarf hamsters and house mice. We investigated three potential characteristic gene expression phenotypes in hybrids including the propensity of transgressive differentially expressed genes towards over or underexpression, the influence of developmental stage on patterns of misexpression, and the role of the sex chromosomes on misexpression phenotypes.

Electrochemical Aptamer-Based Biosensor for Detecting Pap31, a Biomarker for Carrion's Disease.

Carrion's disease, caused by infection with the bacterium (), is effectively treated with antibiotics, but reaches fatality rates of ~90% if untreated. Current diagnostic methods are limited, insufficiently sensitive, or require laboratory technology unavailable in endemic areas. Electrochemical aptamer-based (E-AB) biosensors provide a potential solution for this unmet need, as these biosensors are portable, sensitive, and can rapidly report the detection of small molecule targets.

In Vitro Verification of Simulated Daily Activities Using Implant-Specific Kinematics from In Vivo Measurements.

The mechanism and boundary conditions used to drive experimental joint simulators have historically adopted standardized profiles developed from healthy, non-total knee arthroplasty (TKA) patients. The purpose of this study was to use implant-specific in vivo knee kinematics to generate physiologically relevant boundary conditions used in the evaluation of cadaveric knees post-TKA. Implant-specific boundary conditions were generated by combining in vivo fluoroscopic kinematics, musculoskeletal modeling-generated quadriceps loading, and telemetric knee compressive loading during activities of daily living (ADL) to dynamically drive a servo-hydraulic knee joint simulator.

Phosphatidylethanol measures in patients with severe COVID-19-associated respiratory failure identify a subset with alcohol misuse.

Background: Clinical trials in patients with COVID-19 have exclusively used self- or proxy-reporting to characterize alcohol consumption. The aim of this study was to measure an objective biomarker of recent alcohol use in patients hospitalized with severe COVID-19-associated respiratory failure who were enrolled in an investigational clinical trial to determine the prevalence of alcohol misuse, and to explore the relationship of alcohol use with outcomes.

Methods: We conducted a substudy of patients enrolled in the multicenter, phase 2, adaptive platform design, Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And molecular Analysis in COVID-19 trial (ClinicalTrials.

The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders.

Cumulative research finds that exposure to childhood trauma, sleep dysfunction, and high stress levels are prevalent in youth diagnosed with and at-risk for psychotic disorders. However, few studies have investigated the association between nightly sleep and moment-to-moment stress in youth who are at familial high-risk (FHR) for psychotic disorders with varying levels of exposure to childhood trauma. The current study examined the day-to-day associations between trauma severity, nightly sleep duration, and next-day momentary stress in 19 FHR and 19 non-psychiatric youth (ages 13-19 years, 66 % girls).

Phagolysosomes break down the membrane of a non-apoptotic corpse independent of macroautophagy.

Cell corpses must be cleared in an efficient manner to maintain tissue homeostasis and regulate immune responses. Ubiquitin-like Atg8/LC3 family proteins promote the degradation of membranes and internal cargo during both macroautophagy and corpse clearance, raising the question how macroautophagy contributes to corpse clearance. Studying the clearance of non-apoptotic dying polar bodies in Caenorhabditis elegans embryos, we show that the LC3 ortholog LGG-2 is enriched inside the polar body phagolysosome independent of autophagosome formation.

Developing Therapists' Multicultural Orientation Using Web-Based Deliberate Practice: An Initial Feasibility, Usability, and Acceptability Study.

The value of skillfully adopting a multicultural orientation (MCO) in psychotherapy has been increasingly recognized. Deliberate practice methods may be helpful in developing this capacity, but limited opportunities for practice and feedback exist. The current study provided an initial test of the feasibility, usability, and acceptability of a self-guided, web-based deliberate practice tool designed to support the development of therapists' MCO: MCO Deliberate Practice Online (MCO-O).

Cost-Effectiveness of Computer-Assisted Cognitive Behavioral Therapy for Depression Among Adults in Primary Care.

Importance: Approximately 1 in 5 adults are diagnosed with depression in their lifetime. However, less than half receive help from a health professional, with the treatment gap being worse for individuals with socioeconomic disadvantage. Computer-assisted cognitive behavioral therapy (CCBT) is an effective and convenient strategy to treat depression; however, its cost-effectiveness in a sociodemographically diverse population remains unknown.

"The System isn't Set up for Us": Stories of young Black women's mental health journey.

Background: Black women are too often overlooked and underserved by the mental health system, resulting in disparities in their access to care and services provided. Little attention has been given to understanding the mental health experiences of Black women or to the development of culturally responsive, effective interventions that promote equitable access and services for these women.

Objectives: This study provides an opportunity to understand the lived experiences of young Black women with mental health challenges and their engagement with mental health services.

Barriers to finding and maintaining pet-inclusive affordable housing: Tenant experiences in Houston, Texas.

The city of Houston, Texas has a growing deficit of available and affordable rental units for low-income residents. Due to pet policies, the shortage of affordable housing potentially puts renters who own pets at greater risk of housing insecurity. In this qualitative study, we use a community-engaged approach to document the lived experiences of finding and maintaining affordable housing among 24 current, former, and aspiring pet owners.

Planned Home Births in the United States Have Outcomes Comparable to Planned Birth Center Births for Low-Risk Birthing Individuals.

Objective: There are lingering concerns in the United States about home birth. We used 2 large (n = 50,043; n = 62,984), national community birth registries to compare maternal and neonatal outcomes for planned home versus planned birth center births.

Methods: To compare outcomes by intended birth site, we used logistic regressions, controlling for demographic and pregnancy risk variables.

Yoga as an intervention for stress: a meta-analysis.

The escalating stress epidemic in modern society has raised concerns about its impact on physical and mental health, prompting the need for effective interventions. Yoga, a multifaceted mind-body practice, has gained recognition for its potential in mitigating perceived stress. Our meta-analysis aimed to estimate yoga's impact on lowering perceived stress as measured by the Perceived Stress Scale.

Physics-Based Machine Learning Trains Hamiltonians and Decodes the Sequence-Conformation Relation in the Disordered Proteome.

Intrinsically disordered proteins and regions (IDPs) are involved in vital biological processes. To understand the IDP function, often controlled by conformation, we need to find the link between sequence and conformation. We decode this link by integrating theory, simulation, and machine learning (ML) where sequence-dependent electrostatics is modeled analytically while nonelectrostatic interaction is extracted from simulations for many sequences and subsequently trained using ML.

Complex emotion processing and early life adversity in the Healthy Brain Network sample.

Objective: Early life adversity (ELA) has shown to have negative impacts on mental health. One possible mechanism is through alterations in neural emotion processing. We sought to characterize how multiple indices of ELA were related to naturalistic neural socio-emotional processing.

Impact of perceived neighborhood social cohesion on vaccination intentions in the post-pandemic era.

Objective: To examine the relationship between perceived neighborhood social cohesion (NSC) and intentions to obtain seasonal influenza and COVID-19 vaccines among US adults post COVID-19 pandemic.

Methods: We conducted a cross-sectional, nationally representative survey of US residents (N = 2189) in May 2023 on their perceived NSC, COVID-19 and seasonal influenza vaccination intentions, healthcare access, perceived risk of COVID-19 or flu infection, loneliness, and trust in doctors. We used bivariate probit regressions to examine joint associations between perceived NSC and intentions to receive influenza and COVID-19 vaccines, controlling for several participant characteristics (e.

The relationship between familial factors and youth mental health outcomes in Korean American families: The mediation effects of youth's negative emotionality.

Depressive symptoms are one of the mental health problems among Korean American (KA) youth. Although several studies examined mental distress among KA youth, few have examined the associations between different familial factors, negative emotionality, and depressive symptoms among them, especially using longitudinal data. Drawing on the Triadic Model of Family Process (TMFP), this study examined the longitudinal associations between Korean-specific aspects of familial factors and depressive symptoms among KA youth and the mediation role of negative emotionality in the relationships.