Bacteria-Produced Algicide for Field Control of Toxic Dinoflagellates Does Not Cause a Cortisol Stress Response in Two Estuarine Fish Species.

Application of algicides produced by naturally occurring bacteria is considered an environmentally friendly approach to control harmful algal blooms. However, few studies assess the effects of bacterial algicides on non-target species, either independently or with other stressors. Here, we measured sub-lethal effects of dinoflagellate-specific algicide IRI-160AA on the estuarine fish Fundulus heteroclitus and Menidia menidia in laboratory experiments.

Determining the intention of receiving the influenza vaccine: a cross-sectional survey among international and domestic college students in the USA.

Objective: Vaccination is the most effective strategy for preventing infectious diseases, yet it is underused in young adults. College students are important targets for the influenza vaccine given this population's low vaccination rates; however, limited research has focused on international college students' vaccination status. This study examined the relationships between the theory of planned behaviour (TPB; attitudes, perceived behavioural control (PBC) and subjective norms) and students' intention of receiving an influenza vaccine.

Mental Illness and Substance Use Disorder Stigma: Mapping Pathways Between Structures and Individuals to Accelerate Research and Intervention.

Researchers, interventionists, and clinicians are increasingly recognizing the importance of structural stigma in elevating the risk of mental illnesses (MIs) and substance use disorders (SUDs) and in undermining MI/SUD treatment and recovery. Yet, the pathways through which structural stigma influences MI/SUD-related outcomes remain unclear. In this review, we aim to address this gap by summarizing scholarship on structural MI/SUD stigma and identifying pathways whereby structural stigma affects MI/SUD-related outcomes.

Atypical scene-selectivity in the retrosplenial complex in individuals with autism spectrum disorder.

A small behavioral literature on individuals with autism spectrum disorder (ASD) has shown that they can be impaired when navigating using map-based strategies (i.e., memory-guided navigation), but not during visually guided navigation.

Impact of COVID-19 Diagnosis on Weight Trajectories of Children in the US National COVID Cohort Collaborative.

Background: The COVID-19 pandemic has exacerbated the obesity epidemic, with both adults and children demonstrating rapid weight gain during the pandemic. However, the impact of having a COVID-19 diagnosis on this trend is not known.

Methods: Using longitudinal data from January 2019 to June 2023 collected by the US National Institute for Health's National COVID Cohort Collaborative (N3C), children (age 2-18 years) with positive COVID-19 test results (n=11,474, 53% male, mean [SD] age 5.

Reflections on deep academic-practitioner partnering for generative societal impact.

While academics increasingly point to the value of engaged scholarship, we describe a more extreme form which we label as "deep partnering"-a long-term, holistic, and dynamic collaboration between academics and practitioners to achieve shared goals. Deep partnering involves interdependent and evolving interactions between academics and practitioners over an extended time period. While such relationships enable generative impact on important issues, these relationships remain challenging as academics spend time in the practitioners' complex worlds, surfacing paradoxes due to the partners' conflicting roles, time horizons, and goals, as well as uncertainty in the partnership's evolution.

Molecular-Scale Simulation of Wetting of Actin Filaments by Protein Droplets.

Liquid phase-separating proteins can form condensates that play an important role in spatial and temporal organization of biological cells. The understanding of the mechanisms that lead to the formation of protein condensates and their interactions with other biomolecules may lead to processing routes for soft materials with tailored geometry and function. Fused in sarcoma (FUS) is an example of a nuclear protein that forms stable complexes, and recent studies have highlighted its ability to wet actin filaments and bundle them into networks.

Tetragonia tetragonioides extract prevented high-fat diet-induced obesity and changed hepatic and adipose transcriptomic signatures in C57BL/6J male mice.

Obesity, often driven by high-fat diets (HFD), is a major global health issue, necessitating effective preventive measures. Tetragonia tetragonoides, a plant with known medicinal properties, has not been extensively studied for its effects on HFD-induced obesity and related genetic changes in mice. This study explores the impact of Tetragonia tetragonoides extract (TTE; 300 mg/kg) on obesity-related traits in C57BL/6J male mice, with a focus on transcriptomic changes in the liver and white adipose tissue (WAT).

The Complexity and Significance of Fibroblast Growth Factor (FGF) Signaling for FGF-Targeted Cancer Therapies.

Fibroblast growth factors (FGFs) have diverse functions in the regulation of cell proliferation and differentiation in development, tissue maintenance, wound repair, and angiogenesis. The goal of this review paper is to (i) deliberate on the role of FGFs and FGF receptors (FGFRs) in different cancers, (ii) present advances in FGF-targeted cancer therapies, and (iii) explore cell signaling mechanisms that explain how FGF expression becomes dysregulated during cancer development. FGF is often mutated and overexpressed in cancer and the different FGF and FGFR isoforms have unique expression patterns and distinct roles in different cancers.

The Significance of Aldehyde Dehydrogenase 1 in Cancers.

The goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development. ALDH is often overexpressed in cancer, and each isoform has a unique expression pattern and a distinct role in different cancers. The abnormal expression of ALDHs in different cancer types (breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal) is presented and correlated with patient prognosis.

Cropland expansion links climate extremes and diets in Nigeria.

Climate change threatens smallholder agriculture and food security in the Global South. While cropland expansion is often used to counter adverse climate effects despite ecological trade-offs, the benefits for diets and nutrition remain unclear. This study quantitatively examines relationships between climate anomalies, forest loss from cropland expansion, and dietary outcomes in Nigeria, Africa's most populous country.

Chiral exceptional point enhanced active tuning and nonreciprocity in micro-resonators.

Exceptional points (EPs) have been extensively explored in mechanical, acoustic, plasmonic, and photonic systems. However, little is known about the role of EPs in tailoring the dynamic tunability of optical devices. A specific type of EPs known as chiral EPs has recently attracted much attention for controlling the flow of light and for building sensors with better responsivity.

Heterogeneity in category recognition across the visual field.

Visual information emerging from the extrafoveal locations is important for visual search, saccadic eye movement control, and spatial attention allocation. Our everyday sensory experience with visual object categories varies across different parts of the visual field which may result in location-contingent variations in visual object recognition. We used a body, animal body, and chair two-forced choice object category recognition task to investigate this possibility.

Treadmill belt accelerations may not accurately replicate kinematic responses to tripping on an obstacle in older people.

Background: Treadmill belt perturbations have high clinical feasibility for use in perturbation-based training in older people, but their kinematic validity is unclear. This study examined the kinematic validity of treadmill belt accelerations as a surrogate for overground walkway trips during gait in older people.

Methods: Thirty-eight community-dwelling older people were exposed to two unilateral belt accelerations (8 m s-2) whilst walking on a split-belt treadmill and two trips induced by a 14 cm trip-board whilst walking on a walkway with condition presentation randomised.

Dispositional coping profiles moderate the links between racial discrimination and mental health in Black Americans.

Objectives: Racial discrimination is consistently linked to negative mental health outcomes. However, less is known about how unique patterns of coping in Black Americans experiencing high discrimination stress may moderate the association between discrimination and mental health. The present study uses person-centered methods to identify and describe latent profiles of coping in Black Americans, to understand how these coping profiles are linked to mental health, and to examine whether latent coping profiles moderate the links between discrimination and mental health.

Gene Expression After Exercise Is Disrupted by Early-Life Stress.

Exercise can be leveraged as an important tool to improve neural and psychological health, either on its own or to bolster the efficacy of evidence-based treatment modalities. Research in both humans and animal models shows that positive experiences, such as exercise, promote neuroprotection while, in contrast, aversive experiences, particularly those in early development, are often neurologically and psychologically disruptive. In the current study, we employed a preclinical model to investigate the therapeutic benefits of exercise on gene expression in the brains of adult rats.

Improving future agricultural sustainability by optimizing crop distributions in China.

Improving agricultural sustainability is a global challenge, particularly for China's high-input and low-efficiency cropping systems with environmental tradeoffs. Although national strategies have been implemented to achieve Sustainable Development Goals in agriculture, the potential contributions of crop switching as a promising solution under varying future climate change are still under-explored. Here, we optimize cropping patterns spatially with the targets of enhancing agriculture production, reducing environmental burdens, and achieving sustainable fertilization across different climate scenarios.

Electrochemo-Mechanical Degradation and Failure of Active Particles in High Energy Density Batteries: A Review.

Failure of the active particles is inherently electrochemo-mechanics dominated. This review comprehensively examines the electrochemo-mechanical degradation and failure mechanisms of active particles in high-energy density lithium-ion batteries. The study delves into the growth of passivating layers, such as the solid electrolyte interphase (SEI), and their impact on battery performance.

Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease.

The SARS-CoV-2 main protease (M or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2 M. TRMT1 installs the ,-dimethylguanosine (m2,2G) modification on mammalian tRNAs, which promotes cellular protein synthesis and redox homeostasis.

Learning science concepts alongside language goals: A telehealth replication of a randomised controlled trial examining whether children with developmental language disorder can learn vocabulary or grammar in combination with curricular science content.

Purpose: We asked whether children with developmental language disorder can learn vocabulary or grammar targets and curricular content simultaneously. We replicated prior work integrating two language interventions into a first-grade science curriculum and extended it by testing delivery via teletherapy.

Method: A parallel arm randomised controlled trial was conducted using telehealth approaches.

Short Term Estradiol Administration Does Not Restore Endothelin-B Receptor-Mediated Vasodilation in Postmenopausal Women.

The endothelin-B receptor (ETR) mediates vasodilation in young women, an effect that is absent in postmenopausal women. We have previously demonstrated that ETR-mediated vasodilation is regulated by estradiol (E) in young women; however, the impact of E on ETR function in postmenopausal women remains unknown. Accordingly, the objective of this study was to test the hypothesis that E exposure restores ETR-mediated dilation in postmenopausal women.

Evaluation of Potential Developmental Precursors to Executive Function in Young Children with Motor Delays: Exploratory Study.

This study aimed to explore whether early developmental abilities are related to future executive function (EF) in children with motor delays. Fourteen children with motor delays ( = 10.76, = 2.

A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation.

Mammalian red blood cells are generated via a terminal erythroid differentiation pathway culminating in cell polarization and enucleation. Actin filament polymerization is critical for enucleation, but the molecular regulatory mechanisms remain poorly understood. We utilized publicly available RNA-seq and proteomics datasets to mine for actin-binding proteins and actin-nucleation factors differentially expressed during human erythroid differentiation and discovered that a focal adhesion protein-Tensin-1-dramatically increases in expression late in differentiation.

Relationship between service receipt during the COVID-19 pandemic and autistic children's multisystem outcomes and autism severity: A SPARK dataset analysis.

Children with autism spectrum disorder (ASD) display a variety of core and co-occurring difficulties in social, communication, everyday functioning, cognitive, motor, and language domains. Receiving a combination of services to accommodate needs of autistic individuals is essential for improving their future outcomes. During the COVID-19 pandemic, reduced service access negatively impacted autistic children's outcomes.