1,217 results match your criteria: "UMass-Memorial Medical Center[Affiliation]"

Article Synopsis
  • Immune checkpoint inhibitors (ICI) are effective cancer treatments but can lead to immune-related side effects, including on the cardiovascular system.
  • A study using 2-[F]FDG PET/CT imaging in 47 lung cancer patients showed that ICI treatment significantly increased arterial inflammatory activity, particularly in areas without prior inflammation.
  • The findings indicate that ICI induces vascular inflammation mainly in patients who have not previously undergone chemotherapy or radiotherapy and do not have cardiovascular risk factors.
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More than 25 million Americans have limited English-language proficiency (LEP) according to the U.S. Census Bureau.

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Multifocal emphysematous osteomyelitis, a do not miss diagnosis for the emergency radiologist: a case report with literature review.

Emerg Radiol

April 2024

Department of Radiology Chan Medical School, University of Massachusetts, UMass Memorial Medical Center, 55 Lake Avenue North, Worcester, MA, 0165, USA.

Emphysematous osteomyelitis (EO) is an uncommon fatal condition with high morbidity and mortality. Simultaneous involvement of the axial and appendicular skeleton with multifocal disease is even rarer, with only a few cases being reported in the literature. We present a case of multifocal emphysematous osteomyelitis in a 56-year-old woman with concurrent emphysematous pyelonephritis complicated by psoas and epidural abscesses.

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Community Radiology Beyond the Relative Value Unit.

Radiology

January 2024

From the Department of Radiology, UMass Chan Medical School, UMass Memorial Medical Center, 55 Lake Ave N, Worcester, MA 01655.

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Multiple switching studies and interchangeability of biosimilars.

Lancet Rheumatol

September 2023

Division of Rheumatology, Department of Medicine, UMass Chan Medical School, Worcester MA, USA; Division of Epidemiology, Department of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester MA, USA; Division of Rheumatology, UMass Memorial Medical Center, Worcester, USA. Electronic address:

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Background: Physical activity (PA) is important for the long-term health and weight management of patients who undergo metabolic and bariatric surgery (MBS). However, the roles of exercise professionals in MBS settings have not been systematically determined.

Objectives: To investigate: (1) who are the professionals implementing PA programming in MBS clinical settings; and (2) what patient-centric tasks do they perform?

Setting: Clinical and academic exercise settings worldwide.

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Study Objective: Enoxaparin is standard of care for venous thromboembolism (VTE) prophylaxis in adult trauma patients, but fixed-dose protocols are suboptimal. Dosing based on body mass index (BMI) or total body weight (TBW) improves target prophylactic anti-Xa level attainment and reduces VTE rates. A novel strategy using estimated blood volume (EBV) may be more effective based on results of a single-center study.

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Health care disparities, which are differences in the attainment of full health potential among population groups, have been documented across medical conditions, clinical settings, and diagnostic and treatment modalities. Deeply rooted health care disparities due to many factors have affected how Black women (BW) view medical care including screening mammography. This article explores health care disparities around breast cancer in BW and how patient distrust, provider biases, race, and social determinants of health continue to have negative effects on breast cancer outcomes in BW, despite medical advances in breast cancer detection and management.

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Article Synopsis
  • Scleroderma is a chronic autoimmune disease that can lead to fibrosis in the skin and internal organs, with recent studies indicating potential ear involvement, although this area remains under-researched.
  • In a review of three scleroderma cases from a temporal bone database, patients exhibited tinnitus and varying degrees of sensorineural hearing loss, alongside significant histological changes in their ear structures.
  • The study found notable changes such as diminished joint spaces, demineralized ossicles, vascular issues, and a reduction in spiral ganglion neurons, suggesting that these factors contribute to hearing and balance problems in scleroderma patients.
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The Advances in Targeted Therapies meets annually, convening experts in the field of rheumatology to both provide scientific updates and identify existing scientific gaps within the field. To review the major unmet scientific needs in rheumatology. The 23rd annual Advances in Targeted Therapies meeting convened with more than 100 international basic scientists and clinical researchers in rheumatology, immunology, infectious diseases, epidemiology, molecular biology and other specialties relating to all aspects of immune-mediated inflammatory diseases.

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Oncologic Safety of Close Margins in Patients With Low- to Intermediate-Grade Major Salivary Gland Carcinoma.

JAMA Otolaryngol Head Neck Surg

February 2024

Miami Cancer Institute, Baptist Health South Florida and the Herbert Wertheim College of Medicine, Florida International University, Miami.

Importance: Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence.

Objective: To evaluate the oncologic outcomes for low- and intermediate-grade salivary carcinomas with close and positive margins.

Design, Setting, And Participants: The American Head and Neck Society Salivary Gland Section conducted a retrospective cohort study from 2010 to 2019 at 41 centers.

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Purpose: Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate approved for the treatment of several advanced cancers; however, severe or fatal interstitial lung disease/pneumonitis can occur. We characterized the computed tomography (CT) patterns of T-DXd‒related pneumonitis as a marker for its clinical severity.

Materials And Methods: Ninety patients with advanced cancers who developed T-DXd‒related pneumonitis in two completed single-arm clinical trials were included.

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ACR Appropriateness Criteria® Breast Implant Evaluation: 2023 Update.

J Am Coll Radiol

November 2023

Specialty Chair, Boston University School of Medicine, Boston, Massachusetts.

This document discusses the appropriate initial imaging in both asymptomatic and symptomatic patients with breast implants. For asymptomatic patients with saline implants, no imaging is recommended. If concern for rupture exists, ultrasound is usually appropriate though saline rupture is often clinically evident.

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Acute Care Advanced Practice Providers' Use of Telehealth During the COVID-19 Pandemic.

AACN Adv Crit Care

December 2023

Ruth Kleinpell is Associate Dean for Clinical Scholarship and Professor, Vanderbilt University School of Nursing, Nashville, Tennessee.

Advanced practice registered nurses and physician assistants, collectively termed advanced practice providers (APPs), have been part of telehealth for many years. During the COVID-19 pandemic, APPs experienced the growth in roles, responsibilities, and tools used for telehealth care delivery. This article uses examples from 3 health systems to highlight the ways in which telehealth use was expanded due to the pandemic, how APP roles were altered across the United States during and after the pandemic, and implications for future practice.

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Article Synopsis
  • Aberrations are a critical risk factor for both myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML), leading to challenges in distinguishing between the two conditions based on blast thresholds.
  • In a study of 76 patients with aberrations, no significant genomic differences were found between MDS and AML, but overall survival was poor, particularly for certain AML subgroups.
  • Key independent risk factors for mortality identified were having AML over MDS, a complex karyotype, multihit status, and the absence of hematopoietic cell transplant (HCT), suggesting these factors should guide treatment decisions.
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Immunotherapy for head and neck cancer: where do we go from here?

Immunotherapy

December 2023

Center for Head & Neck Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

Tweetable abstract Immunotherapy for head and neck cancer shows promising new directions - and challenges ahead. What can we learn from recent trials to improve patient selection and optimize combination therapy?

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Metabolic tumor volume and sites of organ involvement predict outcome in NSCLC immune-checkpoint inhibitor therapy.

Eur J Radiol

January 2024

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Machine Learning Driven Precision, Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria.

Purpose: The purpose of this study was to assess the ability of pretreatment PET parameters and peripheral blood biomarkers to predict progression-free survival (PFS) and overall survival (OS) in NSCLC patients treated with ICIT.

Methods: We prospectively included 87 patients in this study who underwent pre-treatment [F]-FDG PET/CT. Organ-specific and total metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured using a semiautomatic software.

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Walter Bauer, Marian Wilkins Ropes, and the Massachusetts General Hospital.

Rheum Dis Clin North Am

February 2024

Division of Rheumatology, Department of Medicine, UMass Chan Medical School, UMass Memorial Medical Center, Worcester, MA 01605, USA. Electronic address:

Walter Bauer was instrumental in the development of rheumatology as a medical subspecialty, promoting careful clinical observation and description and bringing basic scientists and clinicians together to study the "anatomy, chemical composition, and metabolism of connective tissue" in the laboratory. Marian Wilkins Ropes was a pioneering woman in medicine: the first female medical resident at the Massachusetts General Hospital, the first woman appointed as an assistant professor of clinical medicine at Harvard Medical School, the first woman elected to membership in the American Society of Clinical Investigation, and the first woman elected president of the American Rheumatism Association.

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Comparison of Contrast-enhanced Mammography with MRI Utilizing an Enriched Reader Study: A Breast Cancer Study (CONTRRAST Trial).

Radiology

November 2023

From the Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 4th Floor, Boston, MA 02215 (J.P.); Department of Radiology, UMass Memorial Medical Center, Worcester, Mass (T.S.M.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (L.H.P.); Department of Radiology, Boston University Medical Center, Boston, Mass (J.P., M.D.C.F.); Takeda Pharmaceuticals, Cambridge, Mass (Z.Z.); and Department of Radiology, Penn Medicine, Philadelphia, Pa (E.D.P.).

Background Despite growing interest in using contrast-enhanced mammography (CEM) for breast cancer screening as an alternative to breast MRI, limited literature is available. Purpose To determine whether CEM is noninferior to breast MRI or abbreviated breast MRI (AB MRI) and superior to two-dimensional mammography in an asymptomatic population simulating those who would present for screening and then undergo diagnostic work-up. Materials and Methods This enriched reader study used CEM and MRI data prospectively collected from asymptomatic individuals at a single institution from December 2014 to March 2020.

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Background: Machine learning (ML)-derived notifications for impending episodes of hemodynamic instability and respiratory failure events are interesting because they can alert physicians in time to intervene before these complications occur.

Research Question: Do ML alerts, telemedicine system (TS)-generated alerts, or biomedical monitors (BMs) have superior performance for predicting episodes of intubation or administration of vasopressors?

Study Design And Methods: An ML algorithm was trained to predict intubation and vasopressor initiation events among critically ill adults. Its performance was compared with BM alarms and TS alerts.

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Sleep in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.

Semin Pediatr Neurol

October 2023

Pediatrics and Neurology, UMass Memorial Medical Center, Worcester, MA 01655. Electronic address:

Article Synopsis
  • Sleep issues are prevalent in individuals with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and they can worsen symptoms and increase stress for parents.
  • The article is organized into two parts, focusing separately on ASD and ADHD regarding sleep disorder prevalence and impacts.
  • It also discusses the underlying causes of sleep problems and provides insights on how to evaluate and manage these sleep disorders effectively.
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