2 results match your criteria: "UMR 7592 CNRS-University Paris Diderot[Affiliation]"
Galectin-7 in Epithelial Homeostasis and Carcinomas.
Int J Mol Sci
December 2017
Team Morphogenesis, Homeostasis and Pathologies, Institut Jacques Monod, UMR 7592 CNRS-University Paris Diderot, Sorbonne Paris Cité, 15 rue Hélène Brion, 75013 Paris, France.
Galectins are small unglycosylated soluble lectins distributed both inside and outside the cells. They share a conserved domain for the recognition of carbohydrates (CRD). Although galectins have a common affinity for β-galatosides, they exhibit different binding preferences for complex glycans.
View Article and Find Full Text PDFFriedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.
Antioxid Redox Signal
September 2010
Mitochondria, Metals and Oxidative Stress Laboratory, Institut Jacques Monod (UMR 7592 CNRS-University Paris-Diderot), Paris, France.
Article Synopsis
- Mitochondrial dysfunction and oxidative damage are linked to neurodegenerative diseases like Friedreich ataxia (FRDA), Alzheimer’s, and Parkinson’s.
- FRDA, the most common hereditary ataxia, affects 1 in 50,000 people and is caused by a mutation in the FXN gene, leading to reduced frataxin protein, which disrupts mitochondrial functions.
- The review discusses the underlying molecular mechanisms of FRDA, current understanding of frataxin’s role, and highlights recent therapeutic approaches since there is currently no effective treatment for the disease.