Toward Multidisciplinary Tools for Complex Clinical Psychopharmacology Cases: A Qualitative Study with French Healthcare Professionals.

Purpose: Psychopharmacology prescriptions are complex, partly due to the complexity of the relationship between diagnosis and its etiology, as well as the iatrogenic impact on symptomatology. Many multidisciplinary tools exist to optimize their management and improve evidence-based practice. However, their multidisciplinary integration seems to be a challenge.

Cortical beta power reflects the influence of Pavlovian cues on human decision-making.

Reward-predictive cues can affect decision-making by enhancing instrumental responses towards the same (Specific transfer) or similar (General transfer) rewards. The main theories on cue-guided decision-making consider Specific transfer as driven by the activation of previously learned instrumental actions induced by cues sharing the sensory-specific properties of the reward they are associated with. However, to date, such theoretical assumption has never been directly investigated at the neural level.

Metacognition biases information seeking in assessing ambiguous news.

How do we assess the veracity of ambiguous news, and does metacognition guide our decisions to seek further information? In a controlled experiment, participants evaluated the veracity of ambiguous news and decided whether to seek extra information. Confidence in their veracity judgments did not predict accuracy, showing limited metacognitive ability when facing ambiguous news. Despite this, confidence in one's judgment was the primary driver of the demand for additional information about the news.

Craving changes in first 14 days of addiction treatment: an outcome predictor of 5 years substance use status?

Addiction is considered a chronic disorder that requires long-term treatment. Early identification of predictors of outcome may enable better and early adjustment of treatment. Daily fluctuations of craving have been shown to predict substance use within hours, making it a major target for treatment.

Early auditory impairments as a candidate marker of attenuated sensory symptoms of psychosis.

Background And Hypothesis: Deficits in early auditory processing (EAP), as indexed by tone-matching performance, have been consistently demonstrated in individuals with schizophrenia spectrum disorders. However, the ontogeny of tone-matching deficits in schizophrenia remains relatively unknown. The current study aims to determine the relationship between clinical high risk for psychosis and EAP.

PLB2 mice are impaired in novel and temporal object recognition and show corresponding traits in brain MRI.

Recent clinical trials targeting tau protein aggregation have heightened interest in tau-based therapies for dementia. Success of such treatments depends crucially on translation from non-clinical animal models. Here, we present the age profile of the PLB2 knock-in model of fronto-temporal dementia in terms of cognition, and by utilising a directly translatable magnetic resonance imaging approach.

Proposing a definition for sleep disorders: An epistemological review.

To establish an overarching definition of what constitutes a sleep disorder, it is essential to know which health conditions should be included in the classifications of sleep disorders and to better distinguish the normal from the pathological in sleep medicine. This would bring together several professional organizations in their understanding of this hitherto heterogeneous concept. However, no consensus regarding a general definition of a sleep disorder currently exists.

Exploring the interplay of clinical reasoning and artificial intelligence in psychiatry: Current insights and future directions.

For many years, it has been widely accepted in the psychiatric field that clinical practice cannot be reduced to finely tuned statistical prediction systems utilizing diverse clinical data. Clinicians are recognized for their unique and irreplaceable roles. In this brief historical overview, viewed through the lens of artificial intelligence (AI), we propose that comprehending the reasoning behind AI can enhance our understanding of clinical reasoning.

Psychiatric phenotype in neurodevelopmental myoclonus-dystonia is underpinned by abnormality of cerebellar modulation on the cerebral cortex.

Psychiatric symptoms are common in neurodevelopmental movement disorders, including some types of dystonia. However, research has mainly focused on motor manifestations and underlying circuits. Myoclonus-dystonia is a rare and homogeneous neurodevelopmental condition serving as an illustrative paradigm of childhood-onset dystonias, associated with psychiatric symptoms.

Accepting multiple conditions in psychiatry: From comorbidity to multimorbidity.

The concept of multimorbidity in psychiatry refers to the coexistence of multiple health conditions without conceptualizing a central disorder referring to a patient-centered approach that views every diagnosis equally. It emphasizes a shift from focusing on an index disorder to considering interrelated symptoms crucial in psychiatry due to frequent multimorbidity patterns. In clinical practice, multimorbidity guides patient-centered care helping to address the holistic needs of patients and challenging the organization of mental health care.

The archaeological visibility of chimpanzee (Pan troglodytes) nut-cracking.

The earliest evidence for complex tool use in the archaeological record dates to 3.3 Ma. While wooden tools may have been used by our earliest ancestors, the evidence is absent due to poor preservation.

Predictors of substance use during treatment for addiction: A network analysis of ecological momentary assessment data.

Background And Aims: Ecological momentary assessment (EMA) studies have previously demonstrated a prospective influence of craving on substance use in the following hours. Conceptualizing substance use as a dynamic system of causal elements could provide valuable insights into the interaction of craving with other symptoms in the process of relapse. The aim of this study was to improve the understanding of these daily life dynamic inter-relationships by applying dynamic networks analyses to EMA data sets.

The Critical Trigger for Cognitive Penetration: Cognitive Processing Priority over Perceptual Processing.

The visual perception system of humans is susceptible to cognitive influence, which implies the existence of cognitive perception. However, the specifical trigger for cognitive penetration is still a matter of controversy. The current study proposed that the cognitive processing priority over perceptual processing might be critical for inducing cognitive penetration.

Impacts of risk thresholds and age on clinical high risk for psychosis: a comparative network analysis.

One of the main goals for supporting people with a psychotic disorder is early detection and intervention, and the detection of Clinical High Risk (CHR) is a major challenge in this respect. This study sought to compare core symptoms of CHR for psychosis networks based on two CHR self-assessment tools, across different risk thresholds and age groups. This cross-sectional online investigation analyzed 936 individuals for CHR, in France and the UK, with the Prodromal Questionnaire-16 (PQ-16) and the Perceptual and Cognitive Aberrations (PCA).

A network analysis of catatonia symptoms across diagnoses.

Background: Catatonia, as a transdiagnostic construct, manifests across various psychiatric and non-psychiatric conditions. Understanding how symptom variations impact the catatonia construct and differ across primary diagnoses (schizophrenia, bipolar disorder, unipolar depression, and neurological/metabolic/immunological condition) is essential to refine diagnostic and therapeutic approaches. This study aims to compare the symptom networks and centrality measures of these diagnoses.

Modeling longitudinal relationships between sleep disturbances and depressed mood in postpartum: A cross-lagged panel design.

Background: This short communication explores the interrelationships between depressed mood and sleep disturbances in one-year postpartum period.

Methods: Utilizing data from the Interaction of Gene and Environment of Depression during PostPartum Cohort (IGEDEPP) involving 3310 French postpartum women, we employed a cross-lagged panel model (CLPM) to analyze the relationships between these two symptoms, across three time points (immediate postpartum [<1 week after delivery], early postpartum [<2 months after delivery], and late postpartum [2 months to 1 years after delivery]).

Results: Depressed mood significantly influences sleep disturbances in late postpartum (β = 0.

Oxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain: OXYDOPA Trial.

Background: Among the different types of pain related to Parkinson's disease (PD), parkinsonian central pain (PCP) is the most disabling.

Objectives: We investigated the analgesic efficacy of two therapeutic strategies (opioid with oxycodone- prolonged-release (PR) and higher dose of levodopa/benserazide) compared with placebo in patients with PCP.

Methods: OXYDOPA was a randomized, double-blind, double-dummy, placebo-controlled, multicenter parallel-group trial run at 15 centers within the French NS-Park network.

A multi-resolution ensemble model of three decision-tree-based algorithms to predict daily NO concentration in France 2005-2022.

Understanding and managing the health effects of Nitrogen Dioxide (NO) requires high resolution spatiotemporal exposure maps. Here, we developed a multi-stage multi-resolution ensemble model that predicts daily NO concentration across continental France from 2005 to 2022. Innovations of this work include the computation of daily predictions at a 200 m resolution in large urban areas and the use of a spatio-temporal blocking procedure to avoid data leakage and ensure fair performance estimation.

French guidelines for the diagnosis and management of Tourette syndrome.

The term "Gilles de la Tourette syndrome", or the more commonly used term "Tourette syndrome" (TS) refers to the association of motor and phonic tics which evolve in a context of variable but frequent psychiatric comorbidity. The syndrome is characterized by the association of several motor tics and at least one phonic tic that have no identifiable cause, are present for at least one year and appear before the age of 18. The presence of coprolalia is not necessary to establish or rule out the diagnosis, as it is present in only 10% of cases.