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Induction of protective immunity against toxoplasmosis in mice by immunization with Toxoplasma gondii RNA.
Vaccine
March 2006
Université François-Rabelais de Tours, INRA, UMR 0483 Université-INRA d'Immunologie Parasitaire et de Vaccinologie, IFR Agents Transmissibles et Infectiologie, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France.
Toxoplasma gondii enters the mucosal surfaces of the host, and so immunity at these sites is of major interest. Due to the compartmentalization of the immune response, systemic immunization does not induce high levels of immunity at mucosal surfaces. Intranasal immunization has been shown to be very effective in inducing both systemic and mucosal immune responses.
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