Causal analyses with target trial emulation for real-world evidence removed large self-inflicted biases: systematic bias assessment of ovarian cancer treatment effectiveness.

Background And Objectives: Drawing causal conclusions from real-world data (RWD) poses methodological challenges and risk of bias. We aimed to systematically assess the type and impact of potential biases that may occur when analyzing RWD using the case of progressive ovarian cancer.

Methods: We retrospectively compared overall survival with and without second-line chemotherapy (LOT2) using electronic medical records.

Additional treatment with mistletoe extracts for patients with breast cancer compared to conventional cancer therapy alone - efficacy and safety, costs and cost-effectiveness, patients and social aspects, and ethical assessment.

Background: Chemotherapy is often used in the treatment of breast cancer in women. Side effects such as diarrhea, fatigue, hair loss, fever or disturbances in blood formation impair the women's quality of life. An essential treatment goal of the accompanying mistletoe therapy (MT) used in complementary medicine is to improve the health-related quality of life during cancer therapy.

Central nervous activity during a dot probe task with facial expressions in fibromyalgia.

Fibromyalgia syndrome (FMS) is a chronic pain condition accompanied by affective symptoms and cognitive impairments. This study investigated central nervous correlates of attentional and emotional processing in FMS. Therefore, event-related potentials were recorded in 26 FMS patients and 26 healthy controls during a dot probe task, which required participants to decide which side of the screen an asterisk was displayed on; the asterisk was immediately preceded by a facial expression (anger, pain, happiness, neutral) on the left or right side.

Central nervous activity during implicit processing of emotional face expressions in fibromyalgia syndrome.

Objective: Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain accompanied by symptoms like fatigue, insomnia, depression, anxiety and cognitive impairments. In addition to central nervous pain sensitization, emotional dysregulation may be involved in FMS pathogenesis. This study investigated central nervous correlates of affective and attentional processing in FMS using an implicit task.

Facial Emotion Recognition and Executive Functions in Fibromyalgia.

Objective: The ability to accurately identify facial expressions of emotions is crucial in human interaction. Although a previous study suggested deficient emotional face recognition in patients with fibromyalgia, not much is known about the origin of this impairment. Against this background, the present study investigated the role of executive functions.