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Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.
Mol Cancer
May 2010
Division of Medical Oncology, Department of Internal Medicine, UMDNJRobert Wood Johnson Medical School and The Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Background: Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (1D11, a mouse monoclonal pan-TGF-beta neutralizing antibody and LY2109761, a chemical inhibitor of TGF-beta type I and II receptor kinases) on sublines of basal cell-like MDA-MB-231 human breast carcinoma cells that preferentially metastasize to lungs (4175TR, 4173) or bones (SCP2TR, SCP25TR, 2860TR, 3847TR).
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