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MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients.

Medicine (Baltimore)

October 2016

Department of Cardiovascular Surgery, Beijing Lab for Cardiovascular Precision Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Epidemiology and Biostatistics, Imperial College London, London, UK Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.

Matrix metalloproteinases-2 (MMP-2) plays an important role in the pathogenesis of type A aortic dissection (AD). The aim of this study was to evaluate the association of 3 single nucleotide polymorphisms (SNPs) in the MMP-2 gene with type A AD risk and aortic diameters in patients. We performed a case-control study with 172 unrelated type A AD patients and 439 controls.

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