Rehabilitation and care after hip fracture: a cost-utility analysis of stepped-wedge cluster randomized trial.

Objective: To estimate the effectiveness and costs of Rehabilitation for Life (RFL) compared with usual rehabilitation and care after hip fracture to determine which course offered the most value for money.

Design: Cost-utility analysis.

Patient: Community-dwelling patients aged 65+ after hip fracture.

Gastrointestinal hormones and subjective ratings of appetite after low-carbohydrate vs low-fat low-energy diets in females with lipedema - A randomized controlled trial.

Background: Ketosis seems to attenuate, or prevent, the rise in both ghrelin concentrations and subjective hunger ratings that follow weight loss. However, most of the previous studies have employed very-low energy diets (VLED) and are therefore limited in terms of generalizability.

Objectives: To compare changes in ghrelin plasma concentrations after a low-carbohydrate (LCD) versus an isocaloric low-fat low energy diet (LED) in females with lipedema.

Sex Differences in Performance and Performance-Determining Factors in the Olympic Winter Endurance Sports.

Background: Most sex comparisons in endurance sports have been derived from performance-matched groups of female and male athletes competing over similar distances within summer sports. Corresponding analyses of sex differences in winter endurance sports have not previously been conducted. In the Olympic Winter Games (OWG), the endurance sports include cross-country skiing (XCS), biathlon (BIA), Nordic combined (NC), ski mountaineering (SkiMo) and long-track speed skating (SpSk).

Periodontitis and dental quality of life predict long-term survival in head and neck cancer.

Background: Our aim was to investigate oral health in newly diagnosed head and neck squamous cell carcinoma (HNSCC) patients in relation to long-term survival. We assessed whether the level of alveolar bone loss due to periodontitis at diagnosis, measured from orthopantomogram (OPG), and reported dental health-related quality of life (HRQoL) scores obtained at diagnosis contain prognostic information for HNSCC patients.

Methods: A total of 79 patients from a consecutive cohort of 106 diagnosed with HNSCC between November 2002 and June 2005 were included.

Melting simulations of high-entropy carbonitrides by deep learning potentials.

The melting temperature is a crucial property of materials that determines their potential applications in different industrial fields. In this study, we used a deep neural network potential to describe the structure of high-entropy (TiZrTaHfNb)CN carbonitrides (HECN) in both solid and liquid states. This approach allows us to predict heating and cooling temperatures depending on the nitrogen content to determine the melting temperature and analyze structure changes from atomistic point of view.

Farmed blue mussels ()-a nutrient-dense resource retaining nutritional value through processing.

This study investigated how farmed blue mussels () can optimize human nutrient intake. A particular focus was on assessing nutrient preservation during steaming and freeze-drying, processes that could deplete nutrients. The study compared the content of essential amino acids and fatty acids in steamed and freeze-dried blue mussels to the nutritional needs of humans and farmed Atlantic salmon ().

Investigating the impact of a pharmacist intervention on inappropriate prescribing practices at hospital admission and discharge in older patients: a secondary outcome analysis from a randomized controlled trial.

Background: Inappropriate medication prescribing in older patients increases the risk of poorer health outcomes and increased costs. The IMMENSE trial, integrated a clinical pharmacist into the health care team, to improve medication therapy among older patients, and to investigate the impact on acute revisits to hospital.

Objectives: This study investigated the prevalence of potentially inappropriate medications (PIMs) and prescribing omissions (PPOs) at hospital admission and discharge.

Construct Validity of the Orientation to Life Questionnaire in a General Adult Population in Norway and Its Association with Self-Reported General and Oral Health.

Objective: Individuals' Sense of Coherence (SOC) is measured with the Orientation to Life Questionnaire (OLQ-13). SOC reflects a person's orientation to life and ability to manage stress, which can impact health. The aim of the study was to test the reliability and construct validity of the OLQ-13, with self-reported general and oral health as criterion measures, in a Norwegian general adult population.

Prognostic and therapeutic implication of molecular classification including L1CAM expression in high-risk endometrial cancer.

Introduction: The role of molecular classification and L1CAM in high-risk endometrial cancer is uncertain. We aimed to determine the association of molecular profiling and L1CAM with patterns of relapse and survival.

Material And Methods: This retrospective cohort study included patients referred to Department for Gynecologic Oncology, Oslo University Hospital between January 1, 2006 and December 31, 2017.

The Core of the Matter-Importance of Identification Method and Biological Replication for Benthic Marine Monitoring.

Benthic macrofauna are important and widely used biological indicators of marine ecosystems as they have limited mobility and therefore integrate the effects of local environmental stressors over time. Recently, environmental DNA (eDNA) analysis has provided a potentially more resource-efficient approach for benthic biomonitoring than traditional morphology-based methods. Several studies have compared eDNA with morphology-based monitoring, but few have compared the two approaches using the exact same sediment cores.

Exploring the unconventional: health professionals' experiences into medication-free treatment for patients with severe mental illness.

Background: In January 2017, the Norwegian government mandated the establishment of an inpatient unit for "medication-free treatment" for patients with severe mental illness at the University Hospital of North Norway in Tromsø. This study aims to explore the employees' experiences with this unit.

Method: Focus group interviews were conducted October 2021 - February 2022.

Nutritional quality of diet characterized by the Nutri-Score profiling system and cardiovascular disease risk: a prospective study in 7 European countries.

Background: Nutri-Score is a scientifically validated 5-color front-of-pack nutrition label reflecting the nutrient profile of foods. It has been implemented in several European countries on a voluntary basis, pending the revision of the European labeling regulation. Hence, scientific evidence is needed regarding the ability of the nutrient profile underlying the Nutri-Score (uNS-NPS, 2023-updated version) to characterize healthier foods.

An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.

Introduction: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have received less attention.

Methods: Following Core Outcome Set Standards for Development Recommendations (COSSTAD), this study comprised: Stage 1 - systematic review to identify measures; Stage 2 - consensus groups to identify important outcome constructs for people with PPA (n = 82) and care partners (n = 91); Stage 3 - e-Delphi consensus with 57 researchers.

Alcohol and cause-specific mortality in Russia: the Know Your Heart Study 2015-23.

Background: Alcohol-related mortality in Russia exceeds the world average and presents a critical public health concern. This study assesses the impact of alcohol consumption levels on mortality and investigates mortality predictors among Russians, including people treated for alcohol-related diagnoses (narcology patients).

Methods: We examined 2629 men and women aged 35-69 years who participated in the Know Your Heart study (2015-17), Arkhangelsk, Russia.

The cerebral and cognitive changes after intermittent theta burst stimulation (iTBS) treatment for depression: study protocol for a randomized double-blind sham-controlled trial.

Background: The therapeutic use of intermittent theta burst stimulation (iTBS) delivered to the left dorsolateral prefrontal cortex (LDLPFC) is a relatively new but promising treatment option for depression. There is a need for more knowledge on the mechanisms involved in its antidepressant effects.

Methods: This is a single-centre, prospective, randomized, double-blind, placebo-controlled trial with two arms, iTBS and sham iTBS.

Ethics in the operating room: a systematic review.

Background/objective: The act of surgery involves harming vulnerable patients with the intent that the results will improve their health and, ultimately, help the patients. Such activities will inevitably entail moral decisions, yet the ethics of surgery has only recently developed as a field of medical ethics. Within this field, it is striking how few accounts there are of actions within the operating room.

Transient biopsy-proven progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in an elderly woman without known immunodeficiency: a case report.

Background: Progressive multifocal leukoencephalopathy (PML) is a severe opportunistic brain disease caused by lytic JC polyomavirus (JCPyV) replication in oligodendrocytes. Although JCPyV infection is common in the general population, PML almost exclusively occurs in patients immunocompromised due to untreated HIV/AIDS, haematological malignancies, primary immunodeficiencies, solid organ transplantation, or immunomodulatory treatment of autoimmune diseases. There is no effective antiviral treatment, and recovery depends on immune reconstitution.

Liposomal Nω-hydroxy-l-norarginine, a proof-of-concept: Arginase inhibitors can be incorporated in liposomes while retaining their therapeutic activity ex vivo.

Cancer immunotherapy has evolved significantly over the last decade, with therapeutics targeting the adaptive immune system showing exciting effects in clinics. Yet, the modulation of the innate immune system, particularly the tumor-associated innate immune cells which are an integral part of immune responses in cancer, remains less understood. The arginase 1 (Arg1) pathway is a pivotal metabolic pathway that tumor-associated innate immune cells exploit to create an immunosuppressive tumor microenvironment, leading to the evasion of immune surveillance.

"Going under the radar": barriers to continuity in the rehabilitation trajectories of adults with acquired brain injury in North Norway.

Purpose: Acquired Brain Injury (ABI) is a major cause of disability, but rehabilitation services for adults with ABI discharged home remains deficient. This study explores barriers to continuity in the rehabilitation trajectories of this population in North Norway.

Materials And Methods: Data were generated from focus groups consisting of individuals with ABI and family caregivers ( = 5) and healthcare professionals ( = 14).

Synthesis, Electrochemistry and Density Functional Theory of Osmium(II) Containing Different 2,2':6',2″-Terpyridines.

In coordination chemistry, 2,2':6',2″-terpyridine is a versatile and extensively studied tridentate ligand. Terpyridine forms stable complexes with a variety of metal ions through coordination sites provided by the three nitrogen atoms in its pyridine rings. This paper presents an electrochemical study on various bis(terpyridine)osmium(II) complexes, addressing the absence of a systematic investigation into their redox behavior.

Family Health Care Needs in a Pediatric Population 6 Months After Moderate and Severe Physical Trauma.

: Traumatic injury is a leading cause of death and disability in children and young adults. There is a lack of evidence-based literature and guidelines on supporting families after severe child injury. This study aimed to assess the family needs and factors associated with those needs.