9 results match your criteria: "UI Carver College of Medicine[Affiliation]"

This case reviews the clinical course of an elderly woman on chronic total parenteral nutrition who developed sepsis secondary to a rare, newly described gram-negative rod known as The patient noticed a leak in her Hickman catheter when infusing her nutrition. 24 hours after a new catheter was replaced, the patient developed fevers, chills and weakness. She presented to the hospital with hypotension and tachycardia, meeting shock criteria.

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Mitochondrial disorders: Emerging paradigms and the road ahead to personalized medicine.

Neurotherapeutics

January 2024

Department of Pediatrics, Division of Medical Genetics and Genomics, UI Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, Iowa, 52242, United States. Electronic address:

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Cancer, characterized by the uncontrolled proliferation of aberrant cells, underscores the imperative for innovative therapeutic approaches. Immunotherapy has emerged as a pivotal constituent in cancer treatment, offering improved prognostic outcomes for a substantial patient cohort. Noteworthy for its precision, immunotherapy encompasses strategies such as adoptive cell therapy and checkpoint inhibitors, orchestrating the immune system to recognize and selectively target malignant cells.

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Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin's lymphoma (NHL), accounting for 5% of all cases. Due to its virulence factor, it is an incurable disease and keeps relapsing despite an intensive treatment regimen. Advancements in research and drug discovery have shifted the treatment strategy from conventional chemotherapy to targeted agents and immunotherapies.

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Clinical and functional heterogeneity associated with the disruption of retinoic acid receptor beta.

Genet Med

August 2023

CHU Sainte-Justine Research Center, Montréal, QC, Canada; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada; Department of Neurosciences, Université de Montréal, Montréal, QC, Canada. Electronic address:

Article Synopsis
  • Dominant variants in the RARB gene cause MCOPS12, a type of microphthalmia that comes with various birth defects and developmental delays, impacting 25 individuals in this study.
  • The research employed transcriptional assays and structural analysis to evaluate how these RARB variants affect its typical function, revealing both gain-of-function and loss-of-function activities.
  • Findings indicate that while RARB disruption leads to a variety of clinical outcomes, some affected individuals may not show key symptoms like eye abnormalities or motor issues, highlighting the complexity of these genetic variations.
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The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice.

Leukemia

January 2015

1] Interdisciplinary Graduate Program in Immunology, University of Iowa (UI), Iowa City, IA, USA [2] Department of Pathology, UI Carver College of Medicine, Iowa City, IA, USA.

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Background: This prospective randomized controlled study examined outpatient clinical teaching in the presence of the patient.

Methods: In 2006, patients in ambulatory internal medicine clinics at the University of Iowa were randomized to have faculty-learner presentations either in their presence or in the conference room. Staffing encounters were timed and faculty, learners and patients completed postencounter surveys.

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