Human amniotic membrane for the treatment of large and refractory macular holes: a retrospective, multicentric, interventional study.

Background: The purpose of the current study is to report the anatomical and functional results of off-label human amniotic membrane graft as primary intervention to repair large to giant macular holes and in reoperations when wide internal limiting membrane peeling was unsuccessful.

Methods: Retrospective chart review was carried out in five different centers to identify all cases that had undergone off-label human amniotic membrane graft for the treatment of large or failed macular holes (MH). Data collected included age, gender, other concomitant diagnosis, symptoms duration, lens status, number of previous surgeries, macular hole measurements (minimum and base linear diameters), mean post-operative follow-up (months), and pre- and post-operative best corrected visual acuity (BCVA).

Influence of Er,Cr:YSGG laser on dentin acid resistance after erosive challenge.

Purpose: To evaluate the influence of the Er,Cr:YSGG laser with or without the 5% fluoride varnish on the acid resistance of dentin after erosive challenge.

Methods: 36 incisors were selected and sectioned, obtaining 72 specimens of 4 mm × 4 mm and randomly divided into eight groups (n = 9). In G1: application of Er,Cr:YSGG (0.

Biomechanical behaviour of bulk-fill resin composites in class II restorations.

The aim of this study was to evaluate the biomechanical properties expressed by shrinkage stress, cuspal strain, fracture strength and failure mode in molars with large class II mesio-occlusal-distal restorations. Sixty-four human caries-free third molars were selected and distributed randomly into four groups: Z100 restorative material (Z100), Tetric N-Ceram Bulk-Fill (TNC), Filtek Bulk-Fill (FBF) and Aura Ultra Universal (ABF). The bulk-fill materials were inserted in one singular bulk increment and the conventional composite resin in three ones.

Cutaneous lymphangioma circumscriptum: The relevance of clinical, dermoscopic, radiological, and histological assessments.

Cutaneous lymphangioma circumscriptum (CLC) is a rare congenital malformation of the superficial cutaneous lymphatic ducts. Case report: A 7-year-old boy presented plaque with grouped vesicles resembling a "frog spawn" on the upper left thigh, since 4 months old. The clinical, dermatoscopic and histopathological correlation is of great importance.

Chemical Composition and Bioactivity of Essential Oil from Blepharocalyx salicifolius.

Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant has a diverse chemical constitution but the biological activities of its essential oils have not been thoroughly investigated. The aims of this paper were to evaluate in vitro cytotoxic, antifungal and antibacterial activities of an essential oil from leaves of and to identify its main chemical constituents.

Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4.

Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the virus genotype. Acridones, a group of compounds extracted from natural sources, showed potential antiviral actions against HCV.

Does the moment of fiber post cutting influence on the retention to root dentin?

Despite several advantages associated with pre-fabricated glass-fiber posts, the coronal portion of these posts must be cut to allow their use in various clinical situations. However, cutting the cemented post can generate stress on the bonding interface and affect the bond strength. The aim of this study was to investigate the effect the of fiber post cutting on the bond strength of root canals.

Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro.

Compounds extracted from plants can provide an alternative approach to new therapies. They present characteristics such as high chemical diversity, lower cost of production and milder or inexistent side effects compared with conventional treatment. The Brazilian flora represents a vast, largely untapped, resource of potential antiviral compounds.

Measurement of elastic modulus and Vickers hardness of surround bone implant using dynamic microindentation--parameters definition.

The clinical performance of dental implants is strongly defined by biomechanical principles. The aim of this study was to quantify the Vicker's hardness (VHN) and elastic modulus (E) surround bone to dental implant in different regions, and to discuss the parameters of dynamic microindantion test. Ten cylindrical implants with morse taper interface (Titamax CM, Neodent; 3.

Critical instrumentation area: influence of root canal anatomy on the endodontic preparation.

The aim of this study was to evaluate the root canal anatomy of mandibular incisors before and after endodontic instrumentation, identifying regions inaccessible to the action of files (Critical instrumentation Area - CA) in a three-dimensional perspective. Thirty human mandibular central incisors were selected, assigned to two groups (n=15) and instrumented using ProTaper Universal rotary files. In the RX group, longitudinal digital radiographic images were obtained in the buccolingual (BL) and mesiodistal (MD) views.

Effect of light sources on the bond strength of resin material to thin-walled roots.

The aim of this study was to evaluate the bond strength to the dentin of an adhesive material used for root reinforcement light activated with different sources. Roots were divided into 4 groups (n=15) according to the light source used to activate the resin reinforcement: GI, non-weakened roots (control); GII, halogen light (H) 600 mW/cm²; GIII, LED 800 mW/cm² and GIV, LED 1500 mW/cm². The reinforcement was done with adhesive, composite resin and fiberglass posts.

Effect of silane type and air-drying temperature on bonding fiber post to composite core and resin cement.

This study evaluated the influence of silane type and temperature of silane application on push-out bond strength between fiberglass posts with composite resin core and resin cement. One hundred and sixty fiberglass posts (Exacto, Angelus) had the surface treated with hydrogen peroxide 24%. Posts were divided in 8 groups according to two study factors: air-drying temperature after silane application (room temperature and 60 ºC) and silane type: three pre-hydrolyzed--Silano (Angelus), Prosil (FGM), RelyX Ceramic Primer (3M ESPE) and one two-component silane--Silane Coupling Agent (Dentsply).

Microtensile bond strength of methacrylate and silorane resins to enamel and dentin.

The aim of this study was to evaluate the microtensile bond strength (µTBS) of two substrates (enamel and dentin) considering two study factors: type of composite resin [methacrylate-based (Filtek Supreme) or silorane-based (Filtek LS)] and aging time (24 h or 3 months). Twenty human molars were selected and divided into 2 groups (n=10) considering two dental substrates, enamel or dentin. The enamel and dentin of each tooth was divided into two halves separated by a glass plate.

Effect of surface treatment of fiberglass posts on bond strength to root dentin.

This study evaluated the influence of the surface treatments of fiberglass posts on bond strength to root dentin using push-out test. Forty bovine incisor roots were endodontically treated. The surface of the fiberglass posts (Exacto #2, Angelus) were treated using 4 different protocols (n=10): Control - 70% ethanol for 1 min; 37% phosphoric acid for 1 min; 10% hydrofluoric acid for 1 min; and 24% hydrogen peroxide for 1 min.

Root dentin strain and temperature rise during endodontic treatment and post rehabilitation.

This study investigated the effects of endodontic treatment procedures and different post systems rehabilitation steps on the strain and temperature rise on apical and cervical root dentin regions. Twenty-one extracted human canine teeth had two strain gages attached to the distal root surface and two thermocouples attached to the mesial root surface (cervical and apical). The strain and temperature rise were recorded during the following procedures: root canal preparation, final rinse and drying, root canal filling and canal relief.

Effect of the crown, post, and remaining coronal dentin on the biomechanical behavior of endodontically treated maxillary central incisors.

Statement Of Problem: It is unclear how the amount of remaining coronal dentin and the type of post and core rehabilitation affect the strain, stress distribution, and fracture resistance of endodontically treated teeth.

Purpose: The purpose of this study was to evaluate the effects of the type of post, type of crown, and the amount of remaining coronal dentin on the biomechanical behavior of endodontically treated teeth.

Material And Methods: The investigation was conducted by using 3-dimensional finite element analysis and laboratory tests.

Can the cure time of endodontic sealers affect bond strength to root dentin?

The cure time of endodontic sealers may influence the bond strength of fiber posts to root dentin. Forty teeth were selected and endodontically filled using calcium hydroxide cement and then divided into 2 groups according to the time elapsed between endodontic filling and post luting (n = 20): Immediately - glass fiber post luting immediately after endodontic filling; and Delayed - post luting performed 7 days after endodontic filling. The roots were also subdivided according to resin cement used for post luting (RelyX ARC and RelyX Unicem).

Identification of occlusal prematurity by clinical examination and cone-beam computed tomography.

The aim of this study was to evaluate the ability to identify occlusal prematurity by images from paraxial slices of cone-beam computed tomography (CBCT). For such purpose, a pilot study was performed in which 16 asymptomatic young patients were subjected to a clinical examination, including a careful occlusal analysis and then individual deprogrammer devices ("Lucia's JIG") were fabricated. Premature contacts were clinically identified in centric relation (CR) for each patient by jaw manipulation and interocclusal marking with articulating paper (Accufilm).

Histological evaluation of bone response to pediatric endodontic pastes: an experimental study in guinea pig.

This study aimed to evaluate by the intra-osseous implant technique the most commonly used materials for pulp therapy in pediatric dentistry: calcium hydroxide (CH), Guedes Pinto paste and CTZ paste, according to FDI (1980) and ANSI/ADA (1982) recommendations. Thirty guinea pigs, 10 for each material, divided into experimental periods of 4 and 12 weeks received one implant on each side of the lower jaw symphysis. The external lateral tube wall served as control for the technique.

Effect of post type and restorative techniques on the strain and fracture resistance of flared incisor roots.

Restoring flared endodontically treated teeth continues to be a challenge for clinicians. This study evaluated the effect of post types and restorative techniques on the strain, fracture resistance, and fracture mode of incisors with weakened roots. One hundred five endodontically treated bovine incisors roots (15 mm) were divided into 7 groups (n=15).

Effects of a ferment soy product on the adipocyte area reduction and dyslipidemia control in hypercholesterolemic adult male rats.

Background: Available data on the effects of a fermented soy product enriched with Enterococcus faecium and Lactobacillus Jugurti on circulating lipids and adiposity are not completely settled. This study aimed to observe the effects of a fermented soy product enriched with Enterococcus faecium and Lactobacillus Jugurti on central obesity and dyslipidemia control in Wistar adult male rats.

Methods: Over a period of 8 weeks, animals had "ad libitum" food intake and water consumption as well as body weight and food consumption was monitored.