2 results match your criteria: "UCT Medical School Observatory[Affiliation]"
Gastrin-mediated alterations in gastric epithelial apoptosis and proliferation in a mastomys rodent model of gastric neoplasia.
Digestion
January 2001
Gastrointestinal Clinic, UCT Medical School Observatory, Cape Town, South Africa.
Background/aims: Hypergastrinemia secondary to low acid secretion is associated with gastric carcinoid formation in Mastomys. We investigated the effect of gastrin on oxyntic epithelial apoptosis and proliferation in this model.
Methods: Hypergastrinemia and mucosal hyperplasia were induced by irreversible H(2) receptor blockade with loxtidine.
Characterization of six patients who are double heterozygotes for familial hypercholesterolemia and familial defective apo B-100.
Arterioscler Thromb
July 1993
University of Cape Town Research Unit for the Cell Biology of Atherosclerosis, Department of Medical Biochemistry, UCT Medical School Observatory, South Africa.
Familial defective apolipoprotein B-100 (FDB) and familial hypercholesterolemia (FH) are the common causes of monogenic primary hypercholesterolemia. An individual of mixed English and Afrikaner descent with both FDB and the FH Afrikaner-1 low-density lipoprotein receptor mutation was identified in our laboratory. Subsequent analysis of her extended family revealed the presence of heterozygotes for either FH Afrikaner-1, FH Afrikaner-2, or FDB as well as five additional double heterozygotes for FH Afrikaner-1 and FDB and one "complex" heterozygote with all three mutations.
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