Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect.

Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with high propensity for lymphatic spread and distant metastasis. It is prominent as an endemic malignancy in Southern China and Southeast Asia regions. Studies on NPC pathogenesis mechanism in the past decades such as through Epstein Barr Virus (EBV) infection and oncogenic molecular aberrations have explored several potential targets for therapy and diagnosis.

Preparation and Characterization of Magnetite-Polyvinyl Alcohol Hybrid Nanoparticles (As-PVA-MNPs) Using Acanthophora spicifera Marine Algae Extract for Enhanced Antimicrobial Activity Against Pathogenic Microorganisms.

The present study focused on preparing and characterizing magnetite-polyvinyl alcohol (PVA) hybrid nanoparticles using Acanthophora spicifera marine algae extract as a reducing agent. Various analytical techniques, including UV-Visible spectrometry, Fourier-transform infrared (FTIR) analysis, energy-dispersive X-ray (EDX), scanning electron microscopy (SEM), and X-ray diffraction (XRD) analysis, were used to characterize the nanoparticles. The results showed the successful synthesis of nanoparticles with a characteristic color change and absorption peak at 400 nm in UV-Visible spectrometry.

Synergistic enhancing effect of xanthan gum, carboxymethyl cellulose and citric acid on the stability of betacyanins in fermented red dragon fruit () drink during storage.

Nowadays, the demand for using healthy natural pigments (betacyanins) in the food industry is increasing. The present study aimed to overcome the circumstances that render the betacyanins instability in the red dragon fruit drink using mild approaches. These included optimised fermentation, incorporation of anionic polysaccharide mixture solution [xanthan gum (XG, 0.

Obesogenic Environment in the medical field: First year findings from a five-year cohort study.

Doctors with a normal BMI and healthy living habits have shown to be more confident and effective in providing realistic guidance and obesity management to their patients. This study investigated obesogenic tendencies of medical students as they progress in their medical studies. A cohort of forty-nine medical students enrolled in a five-year cohort study and was followed up after one year.

Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment.

Yang et al. recently demonstrated the high potential of liquid metal microspheres (LM MSs) in cancer therapy. By amplifying the effects of magnetic hyperthermia and embolization, LM MSs not only target primary tumors, but also potentiate immune defenses.

Dielectric properties of urine in relation to bladder cancer.

Many studies have investigated the dielectric properties of human and animal tissues, particularly to differentiate between normal cells and tumors. However, these studies are invasive as tissue samples have to be excised to measure the properties. This study aims to investigate the dielectric properties of urine in relation to bladder cancer, which is safe and non-invasive to patients.

Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris.

Zinc oxide nanoparticles have high levels of biocompatibility, a low impact on environmental contamination, and suitable to be used as an ingredient for environmentally friendly skincare products. In this study, biogenically synthesized zinc oxide nanoparticles using are used as a reducing and capping agent for topical anti-acne nanogels, and the antimicrobial effect of the nanogel is assessed on and . leaf extract was examined for the presence of secondary metabolites and its total amount of phenolic and flavonoid content was determined.

A cross-cultural comparison of work engagement in the relationships between trust climate - Job performance and turnover intention: Focusing China and Pakistan.

While the significance of cross-cultural research has been acknowledged over time, there remains a gap in understanding its relationship with employee outcomes. This study delves into the associations between organizational trust climate (TC) and job performance (JP), as well as turnover intention (TI), seeking to ascertain if work engagement (WE) plays a mediating role. Additionally, the research investigates potential differences in the mediating effect between China and Pakistan.

The impact of an online educational game on breast cancer awareness among university female students, Malaysia: a pilot study.

Background: Breast cancer is one of the world's most prevalent cancer and the most common type of cancer in Malaysia. Interestingly, breast cancer in young women is more aggressive compared to older women and the survival rate among these groups of individuals is poor. Thus, breast cancer awareness is essential among young women as early detection is possible and treatment will be effective during which the disease is curable.

Green finance and environmental, social, and governance: evidence from Chinese listed companies.

In recent years, academics have paid more attention to green finance, and public companies have reached a broad consensus on the concept of timely environmental, social, and governance (ESG) disclosure. Due to the close relationship between green finance and ESG, this presents an opportunity to determine whether green finance compels companies to actively disclose ESG. The sample for this study consists of China's non-financial A-share listed companies from 2010 to 2021, and the empirical findings demonstrate that green finance can positively influence the ESG performance of listed companies.

Pivotal Role of Slitrk1 in Adult Striatal Cholinergic Neurons in Mice: Implication in Tourette Syndrome.

Objective: The SLIT and NTRK-like 1 (SLITRK1) gene mutation and striatal cholinergic interneurons (ChIs) loss are associated with Tourette syndrome (TS). ChIs comprise only 1 to 2% of striatal neurons but project widely throughout the stratum to impact various striatal neurotransmission, including TS-related dopaminergic transmission. Here, we link striatal Slitrk1, ChI function, and dopaminergic transmission and their associations with TS-like tic behaviors.

Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer.

Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer that is highly associated with Epstein-Barr virus (EBV) infection. EBV acts as an epigenetic driver in NPC tumorigenesis, reprogramming the viral and host epigenomes to regulate viral latent gene expression, and creating an environment conducive to the malignant transformation of nasopharyngeal epithelial cells. Targeting epigenetic mechanisms in pre-clinical studies has been shown promise in eradicating tumours and overcoming immune resistance in some solid tumours.

Facile Preparation of Durable and Eco-Friendly Superhydrophobic Filter with Self-Healing Ability for Efficient Oil/Water Separation.

The superhydrophobic feature is highly desirable for oil/water separation (OWS) operation to achieve excellent separation efficiency. However, using hazardous materials in fabricating superhydrophobic surfaces is always the main concern. Herein, superhydrophobic filters were prepared via an eco-friendly approach by anchoring silica particles (SiO) onto the cotton fabric surface, followed by surface coating using natural material-myristic acid via a dip coating method.

Orange Dye and Silicone Glue Composite Gel-Based Optimized Impedimetric and Capacitive Surface-Type Proximity Sensors.

Optimized surface-type impedimetric and capacitive proximity sensors have been fabricated on paper substrates by using rubbing-in technology. The orange dye (OD) and silicone glue (SG) composite-gel films were deposited on the zig-zag gap between two aluminum electrodes fixed on a paper (dielectric) substrate. The effect of proximity of various objects (receivers) on the impedance and the capacitance of the sensors was investigated.

Dataset on macroeconomic indicators and fiscal decentralisation indices' variables in Central Java Province, Indonesia.

Macroeconomics data was collected through the Central Statistics Agency (BPS) Central Java Province for the thirty-five regencies and municipalities in Central Java Province from 2017 to 2021. The Fundamental index of fiscal decentralisation () and Enhanced index of fiscal decentralisation () were adapted from [1] and corresponding datasets matched to fiscal data from the Central Java province government. The data sources and indices' calculation methodologies were described in detail.

Validation of the Malay version of the Life Events Checklist for DSM-5 among Malaysian undergraduates.

This cross-sectional study aimed to validate the Life Events Checklist for DSM-5 (LEC-5) among Malaysian undergraduates (N = 500; mean age = 21.66 ± 1.57), of which 90.

Multifunctional Lanthanide Metal-Organic Frameworks Based on -NH Modified Ligand: Fluorescent Ratio Probe, CrO Ions Adsorption, and Photocatalytic Property.

In response to the growing concern for environmental pollution, two lanthanide compounds {[Ln(L)(HO)]·4HO} (where Ln = Tb and Gd, HL = 1-amino-2,4,6-benzene tricarboxylic acid) were synthesized using a -NH modified ligand and systematically characterized. Both compounds exhibit remarkable fluorescence response, adsorption of CrO ions, and photocatalytic degradation properties, as well as exceptional acid-base and thermal stability. Remarkably, the pH-dependent exhibits exceptional performance as a fluorescent probe for detecting Fe and CrO/CrO ions in aqueous solutions, while also serving as a ratiometric fluorescent probe for the detection of Cr, offering rapid response, high sensitivity, selectivity, and recoverability advantages in application.

Sleep, light exposure at night, and psychological wellbeing during pregnancy.

Background: Psychological wellbeing during pregnancy is imperative for optimal maternal outcomes. The present study aimed to determine the association between sleep quality, light exposure at night, and psychological wellbeing in the 2 and 3 trimesters of pregnancy.

Methods: This prospective study was conducted in 9 randomly selected government maternity clinics in Kuala Lumpur, Malaysia.

Using Nvivo to Analyze the Impact of Computer Simulation of Parent-Child Cooperative Art Activities on the Growth of Preschool Children.

Psychology originally defined parent-child conflict in terms of interpersonal relationships, where parent-child conflict is a process of inconsistent attitudes between parents and children that occurs in a family setting. For this end, we aims to investigate the influence of parental awareness on preschoolers' perception of parent-child conflict and the mediating role of preschoolers' self-esteem. This paper proposes a dynamic parent-child relationship discovery algorithm based on the impact of parent-child cooperation activities on preschool children's development.

In vitro and in silico cholinesterase inhibitory potential of metabolites from (Weber-van Bosse) M. Masuda.

Unlabelled: Alzheimer's disease (AD) is a neurodegenerative disease that causes deterioration in intelligence and psychological activities. Yet, till today, no cure is available for AD. The marine environment is an important sink of bioactive compounds with neuroprotective potential with reduced adverse effects.

Seasonality, food security, diet quality and nutritional status in urban poor adolescents in Malaysia.

Seasonality was shown to have an effect on food availability and accessibility, increasing the risk of food insecurity and causing poor diet quality and malnutrition. Therefore, this study aimed to determine seasonal effects on household food security status, diet quality, and nutritional status of urban poor adolescents in Malaysia. A cohort study was conducted among 164 adolescents aged 10-17 from 12 People Housing Programme in Kuala Lumpur, Malaysia during the Northeast (November 2021 till March 2022) and Southwest (June 2022 till September 2022) monsoon.