Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionl0kf6tijma2md4fincgll04h9lptvnmf): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: 8192
Message: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated
Filename: helpers/my_audit_helper.php
Line Number: 8919
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 8919
Function: str_replace
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3369
Function: formatAIDetailSummary
File: /var/www/html/application/controllers/Search.php
Line: 168
Function: pubMedSearch_Global
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: 8192
Message: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated
Filename: helpers/my_audit_helper.php
Line Number: 8919
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 8919
Function: str_replace
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3369
Function: formatAIDetailSummary
File: /var/www/html/application/controllers/Search.php
Line: 168
Function: pubMedSearch_Global
File: /var/www/html/index.php
Line: 316
Function: require_once
554 results match your criteria: "UCSF Medical Center.[Affiliation]"
Study Objectives: To evaluate the capability and accuracy of magnetocardiography (MCG) to identify patients with ischemic chest pain from those with non-ischemic pain and to verify normalcy in the MCG in healthy subjects.
Design: We studied 133 patients (mean age 59 ± 14 years, 69 % male) with chronic or acute chest pain syndrome and 63 healthy subjects (mean age 41.7 ± 12.
Ann Allergy Asthma Immunol
December 2024
Division of Allergy, Immunology, Rheumatology, Rochester Regional Health, University of Rochester, Rochester, NY. Electronic address:
Hypogammaglobulinemia is defined as a reduced immunoglobulin level, which can be either primary due to inborn errors of immunity or acquired in the setting of poor antibody production or increased antibody loss. Secondary hypogammaglobulinemia (SHG) should be considered in patients with a history of immunosuppressive therapy, transplant, protein loss syndromes, certain autoimmune conditions, and malignancies, as it can be associated with increased infectious risk. Appropriate history and lab-based screening in these populations can identify SHG allowing treatment and close monitoring as appropriate.
View Article and Find Full Text PDFCurr Oncol
October 2024
Operative Care Line, Urology Section, Michael E DeBakey Veteran Affairs Medical Center, Houston, TX 77030, USA.
The ability of the Veterans Health Administration System to care for veterans with bladder cancer is influenced by the increased complexity of both veterans and the system's capacity to do so, which is determined by personnel and equipment allocation. Herein, we review the guidelines for bladder cancer management in the context of this population and highlight unique veteran characteristics that impact the delivery of bladder cancer care within the Veterans Health Administration System. There are opportunities for standardization and implementation, which can improve the quality of this care, and we summarize the questions for which coordinated research efforts may provide answers.
View Article and Find Full Text PDFEur Urol Oncol
November 2024
UCSF Medical Center-Mission Bay, San Francisco, CA, USA. Electronic address:
Ann Thorac Surg
November 2024
Center for Asian Health, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania; Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, Pennsylvania. Electronic address:
Background: Cardiothoracic surgery lacks gender and racial/ethnic diversity. Recent studies have highlighted disparities based on gender and race/ethnicity among academic cardiothoracic surgeons. The impact of the intersection of these factors on representation and salary is unknown.
View Article and Find Full Text PDFCancer Med
November 2024
Department of Pediatrics, Hem/Onc/BMT, University of Minnesota Medical Center-Fairview, Minneapolis, Minnesota, USA.
Background: Nab-sirolimus (ABI-009, nab-rapamycin; Aadi Bioscience Inc. [Aadi]) is a human albumin-bound form of sirolimus nanoparticles, a potent mTOR inhibitor. This phase I trial was conducted to define dose-limiting toxicities (DLT), maximum tolerated or recommended phase II dose (MTD/RP2D), and pharmacokinetics of Nab-sirolimus in combination with temozolomide and irinotecan.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
October 2024
Cardiology Division, Virginia Commonwealth University/Pauley Heart Center, Richmond, Virginia, USA.
Int J Radiat Oncol Biol Phys
December 2024
Department of Radiation Oncology, University of California San Francisco, San Francisco, California.
J Clin Oncol
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Nat Genet
September 2024
Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Multiple myeloma is a treatable, but currently incurable, hematological malignancy of plasma cells characterized by diverse and complex tumor genetics for which precision medicine approaches to treatment are lacking. The Multiple Myeloma Research Foundation's Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study ( NCT01454297 ) is a longitudinal, observational clinical study of newly diagnosed patients with multiple myeloma (n = 1,143) where tumor samples are characterized using whole-genome sequencing, whole-exome sequencing and RNA sequencing at diagnosis and progression, and clinical data are collected every 3 months. Analyses of the baseline cohort identified genes that are the target of recurrent gain-of-function and loss-of-function events.
View Article and Find Full Text PDFProstate Cancer Prostatic Dis
August 2024
Department of Urology, Duke University Medical Center, Durham, NC, USA.
Importance And Objective: Partial gland ablation (PGA) is increasingly popular as a treatment for men with intermediate-risk prostate cancer (IR-PCa) to preserve functional outcomes while controlling their cancer. We aimed to determine the impact of race and clinical characteristics on the risk of upstaging (≥pT2c) and having adverse pathological outcomes including seminal vesicle invasion (SVI), extra prostatic extension (EPE) and lymph node invasion (LNI) at radical prostatectomy (RP) among men with IR disease eligible for PGA with hemi-ablation (HA).
Design: Retrospective analysis.
Cardiorenal Med
September 2024
Department of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.
Ann Allergy Asthma Immunol
August 2024
Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF Medical Center, San Francisco, California.
Eur Urol
September 2024
Sutter Cancer Center (accruals under Radiological Associates of Sacramento), Sacramento, CA, USA.
Background: Intensification of therapy may improve outcomes for patients with high-risk localized prostate cancer.
Objective: To provide long-term follow-up data from phase III RTOG 0521, which compared a combination of androgen deprivation therapy (ADT) + external beam radiation therapy (EBRT) + docetaxel with ADT + EBRT.
Design, Setting, And Participants: High-risk localized prostate cancer patients (>50% of patients had Gleason 9-10 disease) were prospectively randomized to 2 yr of ADT + EBRT or ADT + EBRT + six cycles of docetaxel.
Neuro Oncol
September 2024
Miami Cancer Institute, Miami, Florida, USA.
Ann Allergy Asthma Immunol
June 2024
Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF Medical Center.
Radiol Clin North Am
July 2024
Department of Radiology and Biomedical Sciences, University of California, San Francisco, UCSF Medical Center, 1825 4th Street, L3185, Box 4034, San Francisco, CA 94107, USA. Electronic address:
Interval breast cancers are not detected at routine screening and are diagnosed in the interval between screening examinations. A variety of factors contribute to interval cancers, including patient and tumor characteristics as well as the screening technique and frequency. The interval cancer rate is an important metric by which the effectiveness of screening may be assessed and may serve as a surrogate for mortality benefit.
View Article and Find Full Text PDFPurpose: Myocardial infarction (MI) with subsequent inflammation is one of the most common heart conditions leading to progressive tissue damage. A reliable imaging marker to assess tissue viability after MI would help determine the risks and benefits of any intervention. In this study, we investigate whether a new mitochondria-targeted imaging agent, F-labeled 2'-deoxy-2'-F-fluoro-9-β-d-arabinofuranosylguanine ([F]F-AraG), a positron emission tomography (PET) agent developed for imaging activated T cells, is suitable for cardiac imaging and to test the myocardial viability after MI.
View Article and Find Full Text PDFEur Urol Oncol
October 2024
Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. Electronic address:
Chemoradiation therapy (CRT) is a treatment for muscle-invasive bladder cancer (MIBC). Using a novel transcriptomic profiling panel, we validated prognostic immune biomarkers to CRT using 70 pretreatment tumor samples from prospective trials of MIBC (NRG/RTOG 0524 and 0712). Disease-free survival (DFS) and overall survival (OS) were estimated via the Kaplan-Meier method and stratified by genes correlated with immune cell activation.
View Article and Find Full Text PDFHead Neck
June 2024
Department of Head and Neck Surgical Oncology, PSL University, Institut Curie, Paris, France.
Background: An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration.
Methods: The Delphi method was used to determine consensus. A 4-member steering committee and a 10-member monitoring committee wrote and revised the guidelines, divided into eight sections.
Blood Adv
June 2024
UCSF Medical Center, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
Although it is evident that standard-dose whole-brain radiotherapy as consolidation is associated with significant neurotoxicity, the optimal consolidative strategy for primary central nervous system lymphoma (PCNSL) is not defined. We performed a randomized phase 2 clinical trial via the US Alliance cancer cooperative group to compare myeloablative consolidation supported by autologous stem cell transplantation with nonmyeloablative consolidation after induction therapy for PCNSL. To our knowledge, this is the first randomized trial to be initiated that eliminates whole-brain radiotherapy as a consolidative approach in newly diagnosed PCNSL.
View Article and Find Full Text PDFPurpose: TPST-1120 is a first-in-class oral inhibitor of peroxisome proliferator-activated receptor α (PPARα), a fatty acid ligand-activated transcription factor that regulates genes involved in fatty acid oxidation, angiogenesis, and inflammation, and is a novel target for cancer therapy. TPST-1120 displayed antitumor activity in xenograft models and synergistic tumor reduction in syngeneic tumor models when combined with anti-PD-1 agents.
Experimental Design: This phase I, open-label, dose-escalation study (NCT03829436) evaluated TPST-1120 as monotherapy in patients with advanced solid tumors and in combination with nivolumab in patients with renal cell carcinoma (RCC), cholangiocarcinoma (CCA), or hepatocellular carcinoma.
Front Neurol
March 2024
Mayo Clinic, Jacksonville, FL, United States.
Arch Pathol Lab Med
March 2024
The Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City (McCloskey).
Context.—: As pathologists retire and leave the field, it is critical to accurately capture employment trends for new-in-practice pathologists. There is always interest in the job market for newly graduated pathology trainees and prospective pathology trainees, but it is unclear how the COVID-19 pandemic may have affected the job search experience.
View Article and Find Full Text PDF