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UCSF Medical Center[Affiliation] Publications | LitMetric

553 results match your criteria: "UCSF Medical Center[Affiliation]"

A Second Look at Secondary Hypogammaglobulinemia.

Ann Allergy Asthma Immunol

December 2024

Division of Allergy, Immunology, Rheumatology, Rochester Regional Health, University of Rochester, Rochester, NY. Electronic address:

Hypogammaglobulinemia is defined as a reduced immunoglobulin level, which can be either primary due to inborn errors of immunity or acquired in the setting of poor antibody production or increased antibody loss. Secondary hypogammaglobulinemia (SHG) should be considered in patients with a history of immunosuppressive therapy, transplant, protein loss syndromes, certain autoimmune conditions, and malignancies, as it can be associated with increased infectious risk. Appropriate history and lab-based screening in these populations can identify SHG allowing treatment and close monitoring as appropriate.

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The ability of the Veterans Health Administration System to care for veterans with bladder cancer is influenced by the increased complexity of both veterans and the system's capacity to do so, which is determined by personnel and equipment allocation. Herein, we review the guidelines for bladder cancer management in the context of this population and highlight unique veteran characteristics that impact the delivery of bladder cancer care within the Veterans Health Administration System. There are opportunities for standardization and implementation, which can improve the quality of this care, and we summarize the questions for which coordinated research efforts may provide answers.

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Intersection of Race and Gender in the Cardiothoracic Workforce: Study of Representation and Salary.

Ann Thorac Surg

November 2024

Center for Asian Health, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania; Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, Pennsylvania. Electronic address:

Background: Cardiothoracic surgery lacks gender and racial/ethnic diversity. Recent studies have highlighted disparities based on gender and race/ethnicity among academic cardiothoracic surgeons. The impact of the intersection of these factors on representation and salary is unknown.

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Background: Nab-sirolimus (ABI-009, nab-rapamycin; Aadi Bioscience Inc. [Aadi]) is a human albumin-bound form of sirolimus nanoparticles, a potent mTOR inhibitor. This phase I trial was conducted to define dose-limiting toxicities (DLT), maximum tolerated or recommended phase II dose (MTD/RP2D), and pharmacokinetics of Nab-sirolimus in combination with temozolomide and irinotecan.

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Article Synopsis
  • Premature ventricular contractions (PVCs) are common in individuals with left ventricular (LV) systolic dysfunction, yet their prevalence in the general population is not well understood.
  • A multicenter study evaluated the prevalence of frequent (PVCs >5%) and high burden (PVCs >10%) PVCs among patients monitored with ambulatory Holter monitors, analyzing demographics and left ventricle ejection fraction (LVEF).
  • Results showed that PVCs >5% and >10% were present in 4% and 5% of participants, respectively, with higher prevalence in older males, while females had a lower occurrence of PVCs despite similar rates when LVEF <50%.
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Multiple myeloma is a treatable, but currently incurable, hematological malignancy of plasma cells characterized by diverse and complex tumor genetics for which precision medicine approaches to treatment are lacking. The Multiple Myeloma Research Foundation's Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study ( NCT01454297 ) is a longitudinal, observational clinical study of newly diagnosed patients with multiple myeloma (n = 1,143) where tumor samples are characterized using whole-genome sequencing, whole-exome sequencing and RNA sequencing at diagnosis and progression, and clinical data are collected every 3 months. Analyses of the baseline cohort identified genes that are the target of recurrent gain-of-function and loss-of-function events.

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Importance And Objective: Partial gland ablation (PGA) is increasingly popular as a treatment for men with intermediate-risk prostate cancer (IR-PCa) to preserve functional outcomes while controlling their cancer. We aimed to determine the impact of race and clinical characteristics on the risk of upstaging (≥pT2c) and having adverse pathological outcomes including seminal vesicle invasion (SVI), extra prostatic extension (EPE) and lymph node invasion (LNI) at radical prostatectomy (RP) among men with IR disease eligible for PGA with hemi-ablation (HA).

Design: Retrospective analysis.

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Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach.

Cardiorenal Med

September 2024

Department of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.

Article Synopsis
  • The study explores the relationship between acute kidney injury (AKI) and myocardial injury (MI) in patients with severe burns, identifying a condition called cardiorenal syndrome (CRS).
  • Researchers measured biomarkers galectin-3 (Gal3) and soluble CD146 (sCD146) daily for the first week after admission to evaluate their effectiveness in predicting CRS.
  • Results indicated that elevated levels of Gal3 at admission and during the week were significantly associated with CRS, showing good predictive performance, while sCD146 was less reliable in this context.
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Delayed drug reactions: The next frontier in drug allergy?

Ann Allergy Asthma Immunol

August 2024

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF Medical Center, San Francisco, California.

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Background: Intensification of therapy may improve outcomes for patients with high-risk localized prostate cancer.

Objective: To provide long-term follow-up data from phase III RTOG 0521, which compared a combination of androgen deprivation therapy (ADT) + external beam radiation therapy (EBRT) + docetaxel with ADT + EBRT.

Design, Setting, And Participants: High-risk localized prostate cancer patients (>50% of patients had Gleason 9-10 disease) were prospectively randomized to 2 yr of ADT + EBRT or ADT + EBRT + six cycles of docetaxel.

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Article Synopsis
  • This study assessed the safety of using immune checkpoint inhibitors (ICIs) — specifically anti-CTLA-4 and anti-PD-1 — for treating newly diagnosed glioblastoma (GBM) patients after standard treatment, aiming to explore combined therapies.
  • A total of 32 patients participated, showing that the treatments were generally well tolerated, with low rates of severe toxicity and no deaths related to the treatments; specifically, the combination treatment did not show increased toxicity compared to single-agent therapies.
  • The findings indicate that the combination of Ipilimumab and Nivolumab could provide promising results for overall and progression-free survival in patients with GBM, supporting further trials to evaluate their efficacy in this setting.
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The shifting paradigm of gastrointestinal disease associated with antibody deficiencies.

Ann Allergy Asthma Immunol

June 2024

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF Medical Center.

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Interval Cancers in Understanding Screening Outcomes.

Radiol Clin North Am

July 2024

Department of Radiology and Biomedical Sciences, University of California, San Francisco, UCSF Medical Center, 1825 4th Street, L3185, Box 4034, San Francisco, CA 94107, USA. Electronic address:

Interval breast cancers are not detected at routine screening and are diagnosed in the interval between screening examinations. A variety of factors contribute to interval cancers, including patient and tumor characteristics as well as the screening technique and frequency. The interval cancer rate is an important metric by which the effectiveness of screening may be assessed and may serve as a surrogate for mortality benefit.

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Purpose: Myocardial infarction (MI) with subsequent inflammation is one of the most common heart conditions leading to progressive tissue damage. A reliable imaging marker to assess tissue viability after MI would help determine the risks and benefits of any intervention. In this study, we investigate whether a new mitochondria-targeted imaging agent, F-labeled 2'-deoxy-2'-F-fluoro-9-β-d-arabinofuranosylguanine ([F]F-AraG), a positron emission tomography (PET) agent developed for imaging activated T cells, is suitable for cardiac imaging and to test the myocardial viability after MI.

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Chemoradiation therapy (CRT) is a treatment for muscle-invasive bladder cancer (MIBC). Using a novel transcriptomic profiling panel, we validated prognostic immune biomarkers to CRT using 70 pretreatment tumor samples from prospective trials of MIBC (NRG/RTOG 0524 and 0712). Disease-free survival (DFS) and overall survival (OS) were estimated via the Kaplan-Meier method and stratified by genes correlated with immune cell activation.

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Background: An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration.

Methods: The Delphi method was used to determine consensus. A 4-member steering committee and a 10-member monitoring committee wrote and revised the guidelines, divided into eight sections.

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Although it is evident that standard-dose whole-brain radiotherapy as consolidation is associated with significant neurotoxicity, the optimal consolidative strategy for primary central nervous system lymphoma (PCNSL) is not defined. We performed a randomized phase 2 clinical trial via the US Alliance cancer cooperative group to compare myeloablative consolidation supported by autologous stem cell transplantation with nonmyeloablative consolidation after induction therapy for PCNSL. To our knowledge, this is the first randomized trial to be initiated that eliminates whole-brain radiotherapy as a consolidative approach in newly diagnosed PCNSL.

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Purpose: TPST-1120 is a first-in-class oral inhibitor of peroxisome proliferator-activated receptor α (PPARα), a fatty acid ligand-activated transcription factor that regulates genes involved in fatty acid oxidation, angiogenesis, and inflammation, and is a novel target for cancer therapy. TPST-1120 displayed antitumor activity in xenograft models and synergistic tumor reduction in syngeneic tumor models when combined with anti-PD-1 agents.

Experimental Design: This phase I, open-label, dose-escalation study (NCT03829436) evaluated TPST-1120 as monotherapy in patients with advanced solid tumors and in combination with nivolumab in patients with renal cell carcinoma (RCC), cholangiocarcinoma (CCA), or hepatocellular carcinoma.

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Article Synopsis
  • The study focuses on adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and severe neurodegenerative disease, emphasizing the importance of prompt and precise diagnosis due to its progressive nature.
  • A review of 291 ALSP cases revealed that only 24.7% received an accurate initial diagnosis, with common misdiagnoses including frontotemporal dementia and multiple sclerosis.
  • The analysis also identified demographic and clinical variations that influenced initial misdiagnosis, highlighting a strong family history in 59.1% of patients and a significant portion presenting with cognitive or psychiatric symptoms.
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Context.—: As pathologists retire and leave the field, it is critical to accurately capture employment trends for new-in-practice pathologists. There is always interest in the job market for newly graduated pathology trainees and prospective pathology trainees, but it is unclear how the COVID-19 pandemic may have affected the job search experience.

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