Endoscopic diagnosis of sarcoidosis in a patient presenting with bilateral exophthalmos and pansinusitis.

Sarcoidosis is a chronic granulomatous disease of unknown etiology. Otolaryngologic and ophthalmologic manifestations occur in 15 to 55% of afflicted individuals, respectively. Neck masses, parotid enlargement, and facial nerve palsy are the most common presenting otolaryngologic complaints, while lacrimal gland enlargement, uveitis, and upper eyelid masses often call the attention of the ophthalmologist.

Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment.

The degree of ototoxic drug sensitivity and hair cell repair was determined in the chinchilla horizontal crista ampullaris after intraotic administration of gentamicin. Histological evaluation was made of 22 cristae ampullaris from one normal and six post-treatment (PT) animal groups killed at 1, 4, 7, 14, 28, and 56 days. New hair cell production was quantified, using the dissector technique.

Distribution of calcitonin gene-related peptide immunoreactivity in vestibular efferent neurons of the chinchilla.

The distribution of calcitonin gene-related peptide immunoreactivity (CGRPi) within efferent vestibular neurons in the chinchilla was investigated using fluorescent retrograde labeling combined with immunohistochemistry. Efferent vestibular neurons were found bilaterally in clusters: dorsolateral (group E1) and medial (group E2) to the genu of CN VII, as well as ventromedial to the descending CN VII fibers in the parvicellular reticular formation (PCR). The percentage of retrogradely labeled cells containing CGRPi was 77.

Quantitative evaluation of dizziness characteristics and impact on quality of life.

Patients attending an outpatient clinic with the complaint of dizziness were given a set of five items to rank the magnitude of the frequency and severity of their dizziness and the impact of dizziness on their quality of life. They were given instruments to evaluate their degree of anxiety and depression. The impact of frequency and severity on the patients' daily activities, on the quality of life, and on the fear of becoming dizzy was self-rated by the patient.