Loin pain hematuria syndrome: pain relief with intrathecal morphine.

Loin pain hematuria syndrome (LPHS) is characterized by hematuria and incapacitating loin pain. The pain experienced with LPHS is, in general, extremely difficult to treat. Many surgical and pharmacologic therapies have been directed at LPHS pain without success.

Lidocaine delays cortical ischemic depolarization: relationship to electrophysiologic recovery and neuropathology.

To determine if the previously reported limitation of i.v. lidocaine in facilitating recovery from cerebral ischemia was related to an effect on ischemic depolarization, we recorded cortical DC potential, electrocorticogram (ECoG) or EEG, and evoked potentials in rabbits subjected to either 3 or 5 min of complete ischemia.

GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons.

The effects of gamma-aminobutyric acid (GABA) on clonal gonadotropin-releasing hormone (GnRH)-secreting hypothalamic (GT1-7) neurons were investigated using patch-clamp and fura-2 imaging techniques. Local application of GABA (100 microM) to GT1-7 cells voltage-clamped in the whole-cell configuration immediately increased membrane conductance and noise consistent with activation of the GABAA receptor-Cl- channel complex. Depolarization activated transient Na+ currents which were abolished by tetrodotoxin (TTX; 0.

Effect of calcium channel agonist (BAY K8644) on volatile anesthetic-mediated depression in neonatal rabbit papillary muscle.

Heart muscle is dependent on the entry of calcium from the extracellular fluid to support contraction, and neonatal hearts are particularly sensitive to reductions in transsarcolemmal entry of calcium. Accordingly, this study evaluated the ability of the calcium channel agonist BAY K8644 to prevent or reverse the myocardial depressant effects of halothane or isoflurane in right ventricular papillary muscles from neonatal rabbits. The ability of BAY K8644 to reverse reductions in force (F) and dF/dt (halothane and isoflurane) or prevent reduction (halothane) was studied.

Progesterone potentiation of bupivacaine arrhythmogenicity in pentobarbital-anesthetized rats and beating rat heart cell cultures.

The effects of progesterone treatment on bupivacaine arrhythmogenicity in beating rat heart myocyte cultures and on anesthetized rats were determined. After determining the bupivacaine AD50 (the concentration of bupivacaine that caused 50% of all beating rat heart myocyte cultures to become arrhythmic), we determined the effect of 1-hour progesterone HCl exposure on myocyte contractile rhythm. Each concentration of progesterone (6.

Effect of dopamine on ventilatory response to incremental exercise in man.

We investigated whether dopamine, an inhibitory neuromodulator in the carotid body, would alter the ventilatory response typically associated with metabolic (lactic) acidosis during exercise. Six subjects performed incremental cycle ergometer exercise to exhaustion during infusions of dopamine (3 micrograms.kg-1.

Alpha 2-adrenergic agonists in cardiovascular anesthesia.

At this time, the unique attributes of alpha 2-agonists in anesthesia lie in their ability to blunt the adrenergic response to the stresses of major surgery, in patients in whom this response is especially undesirable, without incurring the penalty of respiratory depression that attends the use of opioids. It has become more and more apparent that sympathetic/adrenergic activation often has adverse consequences for patient morbidity and mortality, and modification of such activation by drugs may be a valuable option for the anesthesiologist. However, at present, the evidence supporting this statement is "soft," such as improved hemodynamic and metabolic stability.

A comparison of thromboelastogram and template bleeding time in the evaluation of platelet function after aspirin ingestion.

Study Objective: To compare template bleeding time (TBT) with thromboelastography (TEG) in human subjects after aspirin ingestion.

Design: Healthy volunteers were given a single 650 mg dose of aspirin or a dose of 650 mg of aspirin on three successive days. TBT and TEG studies were performed prior to aspirin ingestion and 4, 24, 72, and 168 hours after ingestion.

Hemodynamic effects of dexmedetomidine, an alpha 2-adrenergic agonist, in autonomically denervated dogs.

The hemodynamic effects of the alpha 2-adrenergic agonist, dexmedetomidine (DM), were studied in eight anesthetized, autonomically denervated dogs. Autonomic block decreased mean arterial pressure (MAP) and cardiac index (CI) by approximately 20% to 95 +/- 8 mm Hg and 4.1 +/- 0.

Ventilatory and cardiovascular responses to sufentanil infusion in dogs anesthetized with isoflurane.

The ventilatory and hemodynamic responses to hypoxia, hyperoxia, and hypercapnia before and during sufentanil infusion were studied in 16 chronically tracheostomized dogs anesthetized with two concentrations, 1 and 0.5 minimal alveolar concentration (MAC) of isoflurane. Sufentanil was infused at a rate to obtain a constant end-tidal carbon dioxide (PETCO2) of approximately 50 mm Hg for each isoflurane level.

Acute closed-chest canine model for anaesthesia research.

An acute closed-chest canine model may be useful to study a wide variety of hypotheses relevant to cardiovascular physiology and pharmacology in circumstances which are clinically relevant. The absence of anatomical perturbations allows recovery of the subjects for conservation of animal resources and to serve as their own controls. The use of a chronic tracheostomy has facilitated inhalation anaesthesia without the use of other agents and allows easy access to the trachea in awake animals with minimal adverse effects.