Varying levels of depressive symptoms and lifestyle health behaviors in a low income, urban population.

This study examined the relationships between varying levels of depressive symptoms and key dietary indicators of chronic disease risk, sugar-sweetened beverage (SSB) and fruit and vegetable (F + V) consumption, among a racially/ethnically diverse urban population in Los Angeles County (LAC). Analyses were carried out using data from a 2012 cross-sectional health survey of 1401 low-income public health center clients. Participants with a high level of depressive symptoms consumed 30% more SSBs (IRR = 1.

Scientific Review Committees as part of institutional review of human participant research: Initial implementation at institutions with Clinical and Translational Science Awards.

Introduction: Scientific quality and feasibility are part of ethics review by Institutional Review Boards (IRBs). Scientific Review Committees (SRCs) were proposed to facilitate this assessment by the Clinical and Translational Science Award (CTSA) SRC Consensus Group. This study assessed SRC feasibility and impact at CTSA-affiliated academic health centers (AHCs).

Current practices, facilitators, and barriers experienced by program providers implementing the National Diabetes Prevention Program in Los Angeles County.

Individuals with prediabetes can lower their diabetes risk by participating in the National Diabetes Prevention Program (National DPP), an evidence-based, group lifestyle change program that is taught by a certified lifestyle coach. To date, studies have not explicitly compared National DPP implementation across multiple settings (i.e.

ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (the PRECluDE consortium): Combatting chronic disease comorbidities in HIV populations through implementation research.

Antiretroviral therapy (ART) prevented premature mortality and improved the quality of life among people living with the human immunodeficiency virus (PLWH), such that now more than half of PLWH in the United States are 50 years of age and older. Increased longevity among PLWH has resulted in a significant rise in chronic, comorbid diseases. However, the implementation of guideline-based interventions for preventing, treating, and managing such age-related, chronic conditions among the HIV population is lacking.

Does Exposure to the Campaign Increase Parental Intentions to Promote More Water and Less Sugar-Sweetened Beverage Consumption?

Purpose: To assess if exposure to the Choose Water public health media campaign increased parents' intentions to promote healthier beverage consumption in their household.

Design: A cross-sectional evaluation administered post-campaign.

Setting: A 2017 internet panel survey in Los Angeles County, California.

Exploring Reimbursement Options for the National Diabetes Prevention Program: Lessons Learned From a Pilot Project in Los Angeles, 2014-2018.

Context: Although Medicare and several state Medicaid programs are beginning to cover the cost of delivering the National Diabetes Prevention Program (National DPP), little is known about the logistical challenges to establishing reimbursement options for these services.

Objective: To describe Los Angeles' experience working with payers to identify and establish reimbursement pathways for National DPP providers.

Design: A case study was conducted to identify regional options for covering the costs of the National DPP.

Addressing Challenges to Coordinating the Implementation of Place-Based Chronic Disease Prevention Interventions in Los Angeles.

Context: Chronic disease prevention initiatives have traditionally been structured to address a single disease, potentially limiting the scope of health impacts. In the past decade, initiatives have increasingly adopted a coordinated approach, in which multiple interventions are intended to work synergistically-often in a bounded geographic area-to address interrelated risk factors and diseases. However, despite increased interest in this coordinated approach, few examples exist of how coordination has been operationalized in local public health practice.

Lessons learned from implementing the Supplemental Nutrition Assistance Program Education Small Corner Store Project in Los Angeles County.

As part of the federal Supplemental Nutrition Assistance Program Education (SNAP-Ed) in Los Angeles County (LAC), corner store conversions (CSCs) were an integral part of a broader, more coordinated effort to improve nutrition and to prevent obesity in low-income populations. To date, little is known about this experience in LAC. The present study addresses this gap by describing lessons learned from implementing the SNAP-Ed (SCSP) in this region.

A Geospatial Analysis of Health, Mental Health, and Stressful Community Contexts in Los Angeles County.

Introduction: Despite numerous federal investments, chronic disease continues to disproportionately affect certain communities across the United States. Understanding the regional distribution (including any overlaps) of factors that extend beyond built and food environments, especially factors that may adversely affect chronic disease-related behaviors, is important. This case study of Los Angeles County's geospatial landscape sought to address these gaps in research and practice.

Describing the dynamic translational science landscape through Core Voucher utilization.

Introduction: Core facilities play crucial roles in carrying out the academic research mission by making available to researchers advanced technologies, facilities, or expertise that are unfeasible for most investigators to obtain on their own. To facilitate translational science through support of core services, the University of California, Los Angeles Clinical and Translational Science Institute (UCLA CTSI) created a Core Voucher program. The underlying premise is that by actively promoting interplay between researchers and core facilities, a dynamic feedback loop could be established that could enhance both groups, the productivity of the former and the relevance of the latter.

Residential Mobility Among Elementary School Students in Los Angeles County and Early School Experiences: Opportunities for Early Intervention to Prevent Absenteeism and Academic Failure.

School connectedness is closely linked to academic success: students who are engaged at school have better attendance and academic performance, and are less likely to drop out. Residential mobility - having moved homes - can increase the risk of a negative academic trajectory (e.g.

Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.

Tyrosine kinase inhibitors (TKIs) induce molecular remission in the majority of patients with chronic myelogenous leukemia (CML), but the persistence of CML stem cells hinders cure and necessitates indefinite TKI therapy. We report that CML stem cells upregulate the expression of pleiotrophin (PTN) and require cell-autonomous PTN signaling for CML pathogenesis in BCR/ABL+ mice. Constitutive PTN deletion substantially reduced the numbers of CML stem cells capable of initiating CML in vivo.

Notes From the Field: Creating a Typology of Childhood Obesity Intervention Strategies.

Classification systems can be useful for evaluating and communicating the impact of interventions. We describe how a typology was created to inform the development of a community intervention dose index (CIDI) intended to measure the strength of impacts attributed to multiple childhood obesity intervention strategies implemented in a large, diverse urban jurisdiction in the United States during 2000-2016. The categorization system was constructed via a three-stage process: (Stage 1) identify relevant constructs for categorizing intervention strategies; (Stage 2) review peer-reviewed literature and program requests for proposals to identify and integrate common attributes of intervention strategies based on Stage 1 constructs; and (Stage 3) vet the results from prior stages to develop a final version of the typology, slated for research application and for use in program improvement.

Driving Distractions Among Public Health Center Clients: A Look at Local Patterns During the Infancy of Distracted Driving Laws in California.

To provide a baseline of various driving behaviors and to identify opportunities for prevention of distracted driving during the infancy of state laws that prohibited cellphone use while operating a motor vehicle, the 2010-2011 Distracted Driving Survey collected information on multiple distracted driving behaviors from lower-income clients of three designated, multi-purpose public health centers in Los Angeles County. Descriptive and multivariable negative binomial regression analyses were performed to examine patterns of driving distractions using the Distracted Driving Survey dataset ( = 1,051). The most common distractions included talking to other passengers ( = 912, 86.

Promoting congregant health in faith-based organizations across Los Angeles County, 2013-2016.

The Los Angeles County Department of Public Health (DPH) launched the Nutrition Education and Obesity Prevention (NEOP) Project in fall 2013. As the local arm of the Supplemental Nutrition Assistance Program Education (SNAP-Ed), this project partnered with faith-based organizations (FBOs) in Los Angeles County to implement policy, systems, and environmental change interventions (PSEs) at selected church sites, alongside the usual delivery of health education. A 2-part programmatic assessment was conducted to better understand how the NEOP Faith Based Project at one of the FBOs was implemented during the 2013-2016 SNAP-Ed funding cycle.

A New Bronchodilator Response Grading Strategy Identifies Distinct Patient Populations.

A positive bronchodilator response (BDR) according to American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines require both 200 ml and 12% increase in forced expiratory volume in 1 second (FEV) or forced vital capacity (FVC) after bronchodilator inhalation. This dual criterion is insensitive in those with high or low FEV. To establish BDR criteria with volume or percentage FEV change.

Supplemental Nutrition Assistance Program Education in Los Angeles County: Lessons and observations from the field, 2013-2016.

Although the California Department of Public Health has been delivering nutrition education for nearly two decades, the use of Supplemental Nutrition Assistance Program Education (SNAP-Ed) resources to advance policy, systems, and environmental change interventions (PSEs) to prevent obesity has been relatively recent. To date, most efforts to couple PSEs to conventional nutrition education have not been well-studied and as such, their lessons have not been used extensively in local planning. This special issue seeks to close this gap by sharing lessons from the planning and implementation of these efforts in Los Angeles County during the 2013-2016 SNAP-Ed funding cycle.

Contextual assessment of the breadth and level of investments made by prevention initiatives to improve nutrition and prevent obesity in Los Angeles County, 2010-2015.

To better characterize and understand local investments made by prevention initiatives to address poor nutrition and obesity during 2010-2015, the Los Angeles County Department of Public Health partnered with an evaluation firm in 2014 to conduct a context scan of nutrition education programs (NEs) and policy, systems, and environmental change interventions (PSEs) in Los Angeles County (LAC). Using fiscal year 2012-2013 (FY12-13) as a midpoint for a before/after comparison based in part on the timeline of the last USDA Supplemental Nutrition Assistance Program Education (SNAP-Ed) funding cycle, the scan included both SNAP-Ed and non-SNAP-Ed initiatives. Systematic searches of peer-reviewed and grey literature, relevant organizations' websites and materials, and results from 51 key stakeholder interviews, were completed to help develop a context scan database for LAC.

The added value of establishing a lexicon to help inform, compare, and better understand the implementation of policy, systems, and environmental change strategies in Supplemental Nutrition Assistance Program Education.

Categorization of terms/concepts/constructs that allows for better understanding and comparison of public health interventions is often lacking in program implementation and evaluation. A classification system such as a lexicon, when used appropriately, can help address this need. The present narrative describes a lexicon of policy, systems, and environmental change strategies (PSEs) that was developed and prototyped to aid local implementation of Supplemental Nutrition Assistance Program Education (SNAP-Ed) interventions in obesity prevention.

Healthy food marketing and purchases of fruits and vegetables in large grocery stores.

Healthy food marketing in the retail environment can be an important driver of fruit and vegetable purchases. In Los Angeles County, the (NEOP) program utilized this strategy to promote healthy eating among low-income families that shop at large retail chain stores. The present study assessed whether self-reported exposure to large retail NEOP interventions, including seeing at least one store visual, watching an in-store cooking demonstration, and/or seeing at least one program advertisement, were associated with increased fruit and vegetable purchases.