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Psychosom Med
October 2017
From the Oppenheimer Center for Neurobiology of Stress and Resilience (Tillisch, Mayer, Gupta, Gill, Labus), Departments of Medicine (Tillisch, Mayer, Gupta, Labus), Psychiatry (Mayer, Gupta), Division of Digestive Diseases, David Geffen School of Medicine at UCLA (Tillisch, Mayer, Gupta, Labus), UCLA Microbiome Center, Ahmanson-Lovelace Brain Mapping Center, UCLA (Mayer), Integrative Medicine, GLA VHA (Tillisch), UCLA Brain Research Institute (Labus), Los Angeles, CA; Danone Research (Brazeilles, Le Nevé, Derrien), Palaiseau, France; Microbiome & Human Health Innovation (van Hylckama Vlieg), Hoersholm, Denmark; and Symrise Group (Guyonnet), Clichy-la-Garenne, France.
Objective: Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavioral characteristics of healthy women clustered by gut microbiota profiles.
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