1,704 results match your criteria: "UCL Medical School.[Affiliation]"

Background: Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by adults with diagnosed ADHD in the UK or worldwide.

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Background: Advances in digital healthcare and health information provide benefits to the public. However, lack of digital skills together with access, confidence, trust and motivation issues present seemingly insurmountable barriers for many. Such digital health exclusion exacerbates existing health inequalities experienced by older people, people with less income, less education or who don't have English as a first language.

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Sjögren disease (SjD) is a systemic autoimmune disorder affecting both children and adults, with a wide range of clinical phenotypes. It remains a challenging condition to recognise and diagnose early and manage effectively. The heterogeneous nature of the presentation, variable disease course and overlapping symptoms with other autoimmune conditions often result in delayed diagnosis.

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First Palmar Intermetacarpal Flap for Congenital First Web Contracture: A Case Series.

Microsurgery

January 2025

Pediatric Hand Surgery and Microsurgery, Barcelona Children's Hospital, HM Nens, HM Hospitales, Barcelona, Spain.

Background: Pediatric first web space contractures of the hand can lead to disability in hand function. Several techniques have been proposed for treating this condition. Recently, a new technique involving the first palmar cutaneous flap was described in a cadaveric study.

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Women's Experience of the Consent Process to Planned Caesarean Section and Its Surgical Risk: A Qualitative Study.

BJOG

December 2024

Department of Women's Cancer, Faculty of Population Health Sciences, Medical School Building, EGA Institute for Women's Health, University College London, London, UK.

Objective: To explore how women appreciated the risks discussed within the consent process for planned caesarean section (CS).

Design: Exploratory qualitative interview study.

Setting: NHS Teaching Hospital in Central London.

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Purpose: Although it is well known that photoreceptor damage and color vision loss occur in patients with diabetic retinopathy (DR), the relationship between structural and functional changes in diabetes mellitus (DM) remains unclear. Using highly sensitive measures of photoreceptor structure and function, we aim to determine whether early loss of color sensitivity in DM is also accompanied by decreased cone density.

Methods: Monocular data from 26 patients with DM and 25 healthy controls were examined to assess cone photoreceptor metrics, using confocal adaptive optics scanning light ophthalmoscopy, and red/green (RG) and yellow/blue (YB) color vision thresholds, using the Colour Assessment and Diagnosis test.

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Article Synopsis
  • The study investigates the side effects of BRAF and MEK inhibitors used for treating low-grade gliomas in children, focusing on endocrine dysfunction, particularly glucose dysregulation and hyponatraemia.
  • The analysis reviewed data from 55 pediatric patients treated with these inhibitors from January 2019 to May 2022, finding that some experienced episodes of low sodium levels, especially those with central diabetes insipidus.
  • Clinicians are advised to closely monitor sodium and glucose levels in patients undergoing treatment to manage the risks associated with these medications effectively.
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An update on the pharmacotherapy of gout.

Expert Opin Pharmacother

January 2025

Department of Rheumatology, Royal Free London NHS Foundation Trust, London, UK.

Introduction: Gout is a common form of acute inflammatory arthritis caused by the deposition of monosodium urate crystals within synovium of joints. This leads to severe pain, reducing quality of life for patients with this condition.

Areas Covered: This review summarizes the treatment of both acute flares of gout and urate-lowering therapy based on guidance from various major international societies.

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Article Synopsis
  • The study explores the implementation of a digital health intervention (DHI) designed for supporting self-management among long COVID patients, involving a patient app and a clinician dashboard.
  • Using qualitative analysis and Normalisation Process Theory, researchers found that the DHI was adaptable to various healthcare settings, enhancing collaboration among healthcare professionals while acknowledging the necessity for in-person care.
  • The findings suggest that DHIs can potentially transform traditional healthcare engagement patterns, emphasizing the importance of organizational context and individual experiences in successful implementation.
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  • Lower eyelid blepharoplasty is a surgical procedure aimed at correcting age-related changes in the lower eyelid, such as sagging skin and fat displacement.
  • The anatomy of the lower eyelid is less understood than that of the upper eyelid, leading to a higher risk of complications during surgery.
  • A review of 54 studies emphasizes the importance of understanding lower eyelid structures to avoid complications and enhance surgical results in procedures like orbital fat repositioning.
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This study examined the feasibility of non-invasive infrared thermography to monitor skin graft viability. Sixty-three patients with skin defects attending a single institution from May 2022 to August 2023 were included. Patients underwent full-thickness or split-thickness skin grafts based on clinical indication.

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Indocyanine green (ICG) fluorescence angiography has emerged as an intraoperative method to accurately assess real-time tissue vascularity, perfusion and anastomotic patency in flap surgery. We illustrate a complex case of elbow reconstruction in an elderly patient with a free anterolateral thigh flap, which relied on intraoperative ICG to evaluate the flap pedicle and map the site of arterial occlusion. Supermicrosurgical instrumentation was employed to perform complex perforator-to-perforator anastomosis following resection of the vascular site of the lesion.

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Background: In 2014 the UK government rolled out the then called hostile environment as a series of punitive policies designed to disenfranchise undocumented migrants from living in Britain. As part of these measures upfront charging was introduced in 2017 which saw patients being denied treatment without prior full payment based on their immigration status.

Aim: Assess the knowledge of the charging regulations in a sample of primary care practitioners.

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Evidence shows that the majority of OMFS trainees undertook dentistry as their first degree, however, an increasing number of undergraduates undertaking OMFS training have completed medicine first. It is vital that all undergraduates wanting to commit to another degree have adequate exposure to, and understanding of, the specialty. The aim of our study was to evaluate the perspectives of final-year dental students concerning their exposure to, and perceptions of, OMFS during their undergraduate teaching.

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Article Synopsis
  • - The article serves as a practical guide for neurosurgical trainees and researchers on how to segment images of common cranial lesions like meningioma, GBM, and SAH using both manual and semi-automated methods.
  • - Medical images were sourced from established databases and processed using software like MRIcron and ITK-SNAP, with expert reviews ensuring quality control.
  • - The developed pipeline includes step-by-step guidance, video recordings, and solutions to challenges, highlighting that while semi-automated methods improve efficiency, manual segmentation remains valuable for training and specific cases.
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Cryobiological aspects of upscaling cryopreservation for encapsulated liver cell therapies.

Cryobiology

December 2024

UCL Institute for Liver and Digestive Health, UCL Medical School, Royal Free Campus, London, NW3 2PF, UK. Electronic address:

For the efficient delivery of a cell therapy a treatment must be provided rapidly, at clinical scale, contain a sufficient active cellular component (biomass), and adhere to a multitude of regulatory requirements. Cryopreservation permits many of these demands to be met more readily. Here we present the cryopreservation and recovery of large volume (2.

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Article Synopsis
  • * A thorough review analyzed 390 studies, ultimately focusing on 29 involving 67 patients, revealing that denosumab was primarily used for ABC treatment with positive clinical and radiological results, although some patients experienced tumor recurrences.
  • * Adverse effects were noted, particularly in children, including hypocalcemia and hypercalcemia, highlighting the need for careful patient monitoring and longer follow-up periods; further clinical trials are recommended to solidify these findings.
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Objective: This scoping review aims to map and examine the extent and type of available evidence on health professionals' education accreditation within Africa.

Introduction: The demand for health professionals is unprecedentedly high globally. One response to this challenge has been expanding training through more liberal education policies, facilitating private sector participation in education service provision.

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Background: The National Health Service (NHS) is suffering from a workforce crisis of mental and physical sickness and attrition following the COVID-19 pandemic. An in-depth understanding of healthcare workers' (HCWs) experiences during the pandemic is required to understand the impacts on their mental health in this challenging work environment. This qualitative study explores HCWs' concerns during the COVID-19 pandemic-expressed in real time during an active mental health crisis.

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Snapping of the biceps femoris tendon over the fibular head is a cause of symptomatic lateral knee pain. We presented the case of an active patient in his mid-20s who had bilateral snapping of his biceps femoris tendon, with no history of trauma. The pathophysiology in our case was thought to be secondary to prominent fibular heads.

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