27 results match your criteria: "UA College of Medicine[Affiliation]"
Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes.
Clin Epigenetics
December 2016
Mayo/ASU Center for Metabolic and Vascular Biology, Mayo Clinic in Arizona, Scottsdale, AZ USA ; School of Nutrition and Health Promotion, College of Health Solutions, Arizona State University, 550 N. 3rd Street, Phoenix, AZ 85004 USA ; Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, AZ USA.
Background: Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skeletal muscle DNA methylation in combination with transcriptomic changes in obesity.
View Article and Find Full Text PDFMetabolic syndrome in pediatric cancer survivors: a mechanistic review.
Pediatr Blood Cancer
December 2013
Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona; Department of Child Health, UA College of Medicine-Phoenix, Phoenix, Arizona.
Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissue and molecular end-organ effects of therapy exposures and synthesizes the current understanding of the mechanisms underlying CVD risk in this vulnerable population.
View Article and Find Full Text PDF