1,511 results match your criteria: "U1219; and University of Bordeaux F.C.[Affiliation]"

Disproportionality analyses are the most-commonly used study design used in the post-marketing phase to detect suspected adverse drug reactions in individual case safety reports. Recent years have witnessed an exponential increase in published articles on disproportionality analyses, thanks to publicly accessible databases. Unfortunately, this trend was accompanied by concerns on lack of transparency and misinterpretation of results, both generating unjustified alarm and diluting true signals into overwhelming noise.

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Background: Opioid Use Disorder (OUD) often provokes dramatic consequences in terms of increased morbi-mortality. Two medications have mainly been worldwide used for OUD (MOUD), buprenorphine and methadone. Recently, however, some reports have highlighted the use of Morphine Sulfate (MS) mainly obtained without a prescription but used as MOUD by opioid users and especially People Who Inject Substances (PWIS).

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Psychological intimate partner violence, child witnessing of parental arguments, and emotional-behavioral outcomes in five-years old: The French ELFE cohort.

Child Abuse Negl

February 2025

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Equipe de Recherche en Epidémiologie Sociale (ERES), 75571 Paris, Cedex 12, France.

Background: Intimate partner violence (IPV) is associated with children's emotional and behavioral difficulties. Psychological-IPV (P-IPV) is most common, and occurs alone or along other forms of IPV. Little is known about the longitudinal course of P-IPV exposure and its consequences on children taking into account whether or not they are present during parental arguments.

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Since the pionneer work of Meerwaldt and the Groningen team, who related skin autofluorescence (SAF) to the dermal concentrations of advanced glycation end-products (AGEs), hundreds of articles have been devoted to its application in diabetes. Due to the slow turnover of the AGEs formed on collagen of the skin, the SAF can reflect the progressive accumulation of AGEs and hence be a marker of long-term glucose exposure. Accordingly, relations with HbA1c from the previous 3-10 years have been established in both type 1 and type 2 diabetes, and even in gestational diabetes mellitus.

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The benefits of screening for cytomegalovirus (CMV) infection during pregnancy remain a topic of debate. To date, no randomized trial has compared the impact of screening versus routine management on the prevention of severe sequelae in newborns. Furthermore, it is unclear what actions can be taken in case of a positive screening given that there is limited evidence of effective interventions as no treatments showed significant effect on the frequency of congenital cytomegalovirus infections and, as additional challenge, the window for effective treatment initiation after maternal infection is narrow, estimated to be as short as five weeks.

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Introduction: Improving adverse events following immunisation (AEFI) detection is vital for vaccine safety surveillance, as an early safety signal can help minimize risks. In February 2022, the World Health Organization reported a preliminary signal on sudden sensorineural hearing loss (SSNHL) following coronavirus disease 2019 (COVID-19) vaccination, 54 million persons in France received at least one dose, covering 78.8% of the population within a year.

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[Effects of air pollution on eye health].

Rev Prat

November 2024

Université de Bordeaux, Inserm, BPH, U1219, Bordeaux, France.

EFFECTS OF AIR POLLUTION ON EYE HEALTH. In addition to its well-known effects on cardio-respiratory health, air pollution could also have an impact on eye health. Indeed, certain air pollutants, especially fine particles and nitrogen dioxide, can enter the bloodstream, triggering oxidative and inflammatory mechanisms involved in the development of the major eye diseases (glaucoma, age-related macular degeneration [AMD], cataracts).

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Article Synopsis
  • This study explores the effects of neck muscle vibration (NMV) on visual exploration in post-stroke patients with unilateral spatial neglect (USN), revealing inconsistencies in previous research findings due to diverse methodologies and outcome measures.
  • A total of 25 publications from 1988 to 2023 were analyzed, involving 512 participants, with a significant number (22.3%) having USN, and highlighting common practices in NMV application and testing.
  • The research indicates that while NMV frequency was consistent, the variety in application methods, tasks performed, and outcome measures indicates a need for standardized approaches in future studies.
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Background/objectives: A significant proportion of older adults with Alzheimer's disease or related disorders live in a long-term care facility. This study aimed to determine the time delay between admission and death for older adults with dementia.

Methods: A post hoc analysis was conducted using data from a French observational cohort, identifying older adults with dementia who were admitted to nursing homes.

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Context: Regular alcohol use is a predominant risk factor for disease, injury, and social harm. While robust evidence is advocating for implementing interventions to reduce the harms of illegal substance use, less literature is dedicated to identifying and understanding interventions aiming at reducing the various harms associated with alcohol.

Objectives: This review describes how alcohol harm reduction (AHR) interventions are currently conducted and analyzes the facilitators and barriers identified by the studies on their efficacy.

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Addressing current challenges in population health intervention research for health promotion.

Glob Health Promot

November 2024

University of Bordeaux, INSERM, BPH, U1219, Mérisp/PHARES Equipe Labellisée Ligue Contre le Cancer, Bordeaux, France.

This article explores the role of population health intervention research (PHIR) in enhancing health promotion in France, stressing the importance of a more in-depth understanding and thorough analysis of healthcare interventions. Established in 2022, the So-RISP network aims to structure the PHIR field, consolidating expertise from renowned teams specializing in PHIR, primary cancer prevention, and addiction. In January 2023, So-RISP members convened a national workshop.

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rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.

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Women, gender and drugs: between research and action.

Harm Reduct J

November 2024

University of Bordeaux, INSERM, BPH, U1219, Mérisp/PHARES Team Labelled League Against Cancer, CIC 1401, Bordeaux, F-33000, France.

This article is part of Harm Reduction Journal's special issue on harm reduction research in the francophone context and specifically the Harm Reduction Network (HARENE). After highlighting the history and current context of harm reduction for women in France, we present the results of four research studies addressing the links between gender and drugs which were presented in the book Espaces genrés des drogues. Parcours dans la fête, l'intimité et la réduction des risques ('Gendered Spaces of Drugs.

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Performance of stool-based molecular tests and processing methods for paediatric tuberculosis diagnosis: a systematic review and meta-analysis.

Lancet Microbe

November 2024

Centro de Investigação em Saúde de Manhiça, Manhiça, Mozambique; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Barcelona, Spain; Department of Preventive Medicine and Epidemiology, Hospital Clínic, Barcelona, Spain. Electronic address:

Background: There has been a global pursuit to improve the diagnosis of tuberculosis in young children by applying diagnostic methods on accessible biospecimens such as stool. We aimed to conduct a systematic review on the accuracy of stool-based molecular tests for tuberculosis diagnosis in children and to assess the impact of the available pre-processing methods and other design characteristics.

Methods: In this systematic review and meta-analysis, we evaluated studies in children younger than 16 years with presumptive tuberculosis that were published in English, Spanish, French, and Portuguese from Jan 1, 2000, to May 3, 2024, in MEDLINE, Embase, and Embase Classic, comparing the molecular detection of Mycobacterium tuberculosis DNA in stool with microbiological tests on other samples or a clinical diagnosis.

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New pedagogical tools for vaccine education: preparing future healthcare workers for the next pandemic.

BMC Med Educ

November 2024

University Department of Public Health, Prevention, Observation, and Territories, Faculty of Health Simone Veil, University of Versailles St-Quentin-en-Yveline (UVSQ), Montigny-le-Bretonneux, France.

Vaccine hesitancy (VH) is an issue for healthcare students, influenced by safety concerns and misinformation. The need for better communication training and understanding sociocultural factors in VH was highlighted in a European University Alliance seminar. Practical exercises like simulation role-playing, interprofessional collaboration, and digital literacy may improve vaccine education.

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Background: Female Sex Workers (FSW) in Sub Saharan Africa face multiple challenges increasing their vulnerability to poor health, particularly poor sexual and reproductive (SRH) health outcomes and violence. The aim of this study was to assess the use of gynecology health care services and factors associated with its use as well as experiences of violence among FSW in Togo.

Method: A cross-sectional study was carried out in 2021 among FSW in two cities of Togo.

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Introduction: In 2021, among French women who smoked when they knew they were pregnant, 59% still smoked at the end of pregnancy. Support for pregnant women to stop smoking must include a structured organisational perspective. The main objective of the study is to evaluate the effectiveness of the 5A-QUIT-N organisational intervention on smoking cessation at delivery among pregnant women who smoke during pregnancy.

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Article Synopsis
  • The study investigated the link between air pollution and cataract surgery incidence in older adults in Bordeaux, France.
  • Researchers followed 829 participants aged 65 and older from 1999-2017, monitoring their cataract surgeries and estimating their long-term air pollution exposure.
  • Results showed that long-term exposure to nitrogen dioxide (NO) at levels ≥40 μg/m was significantly associated with increased incidence of cataract surgery, suggesting that meeting air quality standards could benefit public health.
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Objectives: This study aims to identify the factors influencing vaccine hesitancy, willingness and its variation over time in order to inform more responsive strategies for increasing vaccination uptake. The specific objectives are: (1) to describe and compare levels of COVID-19 vaccine hesitancy among the general population in rural and urban settings in West Africa over time and (2) to identify factors associated with COVID-19 vaccination willingness and hesitancy among the general population across five West African countries over time.

Design: Following a baseline survey (Wave I), three serial cross-sectional surveys (Waves II-IV) were implemented.

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Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system affecting approximately 2.8 million people worldwide. In addition to genetic and environmental factors, various lifestyle factors contribute to disease development and progression.

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Article Synopsis
  • Pesticide applications in agriculture create complex mixtures of Plant Protection Products (PPPs) in the environment, which may pose underestimated ecological risks that current regulations do not fully address.
  • This study presents a new methodology to identify priority PPPs for further ecotoxicological testing in edge-of-field water and sediment systems, based on actual quantification from European and Argentine case studies.
  • The research highlights discrepancies between EU risk assessment methods (ECHA vs. EFSA), with ECHA taking a more conservative approach, while EFSA offers a standardized strategy to avoid risk overestimations and provide a balanced view of PPP classes for mixture testing.
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High risk of long-term recurrence after a first episode of venous thromboembolism during pregnancy or postpartum: the REcurrence after a PrEgnAncy related Thrombosis (REPEAT) Study.

J Thromb Haemost

October 2024

Hematology Laboratory, La Timone University Hospital of Marseille, Aix-Marseille University, INSERM 1263, INRAE 1260, C2VN, Marseille, France; Service de médecine vasculaire et Hypertension Artérielle, Faculté de Médecine de Marseille, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone, Marseille, France. Electronic address:

Background: The long-term recurrence risk after a pregnancy-associated venous thromboembolism (VTE) is sparsely assessed.

Objectives: To determine the rate of recurrence after a pregnancy-associated VTE and identify associated risk factors.

Methods: Five hundred eighty-seven women with a history of first VTE occurring during pregnancy or up to 3 months after delivery were referred to La Timone Hospital, Marseille, France.

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