9 results match your criteria: "U1011-European Genomic Institute for Diabetes (EGID)[Affiliation]"

Transesophageal echocardiography (TEE) is a vital diagnostic tool in clinical practice, particularly in transcatheter interventions where it aids in both pre-operative planning and intra-operative guidance. Traditional TEE probes often require general anesthesia due to patient discomfort. However, the development of miniaturized TEE probes presents a promising alternative, enabling routine examinations and interventions with minimal sedation.

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A new compressed sensing cine cardiac MRI sequence with free-breathing real-time acquisition and fully automated motion-correction: A comprehensive evaluation.

Diagn Interv Imaging

November 2023

Univ. Lille, U1011-European Genomic Institute for Diabetes (EGID), 59000 Lille, France; Inserm, U1011, 59000 Lille, France; CHU Lille, Department of Cardiovascular Radiology, 59000 Lille, France; Institut Pasteur Lille, 59000 Lille, France.

Purpose: The purpose of this study was to compare a new free-breathing compressed sensing cine (FB-CS) cardiac magnetic resonance imaging (CMR) to the standard reference multi-breath-hold segmented cine (BH-SEG) CMR in an unselected population.

Materials And Methods: From January to April 2021, 52 consecutive adult patients who underwent both conventional BH-SEG CMR and new FB-CS CMR with fully automated respiratory motion correction were retrospectively enrolled. There were 29 men and 23 women with a mean age of 57.

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Article Synopsis
  • Mitochondrial dysfunction from acute cardiac ischemia-reperfusion may heighten the risk of arrhythmias by affecting energy production, oxidative stress, and calcium balance.
  • A study compared cardiomyocyte action potential duration (APD) and conduction velocity (CV) between Mitofusins-1/2 double-knockout (Mfn-DKO) and wild-type (WT) mice, revealing that Mfn-DKO mice had longer APD and lower baseline CV.
  • Mfn-DKO hearts showed abnormal connexin-43 (Cx43) lateralization, indicating that mitofusins may play a role in the development of cardiac arrhythmias after myocardial injury.
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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

Proc Natl Acad Sci U S A

May 2022

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers.

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Article Synopsis
  • Short-chain fatty acids (SCFAs), particularly acetate, play a critical role in enhancing immune responses by activating macrophages in the lungs to fight bacterial infections.
  • The study reveals that acetate influences macrophage behavior through changes in gene expression, metabolic processes, and boosts nitric oxide production, which is essential for their bactericidal activity.
  • Notably, acetate's effects are linked to the NLRP3 inflammasome and HIF-1α activation via enhanced glycolysis, rather than through traditional receptor pathways or metabolism enzymes.
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Background And Objective: Cardiac magnetic resonance (CMR) is a key tool for cardiac work-up. However, arrhythmia can be responsible for arrhythmia-related artifacts (ARA) and increased scan time using segmented sequences. The aim of this study is to evaluate the effect of cardiac arrhythmia on image quality in a comparison of a compressed sensing real-time (CS) cine sequence with the reference prospectively gated segmented balanced steady-state free precession (Cine) technique regarding ARA.

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Background And Objective: Real-time compressed sensing cine (CS) provides reliable quantification for both ventricles but may alter image quality. The aim of this study was to assess image quality and the accuracy of left (LV) and right ventricular (RV) volumes, ejection fraction and mass quantifications based on a retrogated segmented compressed sensing 2D cine sequence (CS).

Methods: Thirty patients were enrolled.

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Background And Objective: To evaluate the reliability of compressed-sensing (CS) real-time single-breath-hold cine imaging for quantification of right ventricular (RV) function and volumes in congenital heart disease (CHD) patients in comparison with the standard multi-breath-hold technique.

Methods: Sixty-one consecutive CHD patients (mean age = 22.2 ± 9.

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