Treatment of soft tissue sarcomas by preoperative irradiation and conservative surgical resection.

From 1970-1984, 114 patients with soft-tissue sarcomas received preoperative irradiation at U.T.M.

Drug and radiation sensitivity testing of primary human tumor cells using the adhesive-tumor-cell culture system (ATCCS).

In summary, the ATCCS is an efficient culture system which grows clonogenic cells from greater than 80% of human cancers. The ATCCS supports the growth of malignant cells from human cancers. The ATCCS shows classical drug and radiation survival curves which routinely achieve over 1 log of kill.

Release of methyl isocyanate from the antitumor agent caracemide (NSC-253272).

In recent phase 1 clinical trials, caracemide [N-acetyl-N-(methylcarbamoyloxy)-N-methylurea; NSC-253272] has demonstrated a marked potential to produce severe central nervous system (CNS) toxicity. Recent in vitro studies of this antitumor agent have presented indirect evidence indicating that methyl isocyanate is a likely metabolite which results from incubation of caracemide with either phosphate buffer or human plasma. This report presents evidence that methyl isocyanate is formed from caracemide in a concentration- and time-dependent manner.