10,766 results match your criteria: "U.S. Army Medical Department Center & School[Affiliation]"
Nat Biomed Eng
December 2024
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, USA.
Tactile feedback from brain-controlled bionic hands can be partially restored via intracortical microstimulation (ICMS) of the primary somatosensory cortex. In ICMS, the location of percepts depends on the electrode's location and the percept intensity depends on the stimulation frequency and amplitude. Sensors on a bionic hand can thus be linked to somatotopically appropriate electrodes, and the contact force of each sensor can be used to determine the amplitude of a stimulus.
View Article and Find Full Text PDFiScience
December 2024
Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, P.R. China.
Radiotherapy showed synergy with immunotherapy, yet the comparative effectiveness of combining immunotherapy (iRT) or chemotherapy (CRT) after platinum therapy failure in advanced non-small cell lung cancer (NSCLC) remains unexplored. We analyzed 163 patients (iRT: = 120 vs. CRT: = 43) eligible for combination radiotherapy.
View Article and Find Full Text PDFParasit Vectors
December 2024
Kala-Azar Medical Research Center (KAMRC), Muzaffarpur, Bihar, India.
Background: Visceral leishmaniasis (VL), known as Kala-azar on the Indian subcontinent, is a parasitic disease caused by the flagellated protozoa Leishmania donovani and can be fatal if left untreated. The sand fly Phlebotomus argentipes is the only proven vector of VL in the Southeast Asia region, and VL control in this region has relied on the use of synthetic insecticides for indoor residual spraying (IRS). The use of DDT in VL control programmes has led to the development of resistance to this insecticide in sand flies, resulting in DDT being replaced with the insecticide alpha-cypermethrin.
View Article and Find Full Text PDFCureus
December 2024
Department of Family Medicine, Miami Veterans Affairs Medical Center, Miami, USA.
Chest trauma is a common injury in civilian and military polytrauma patients and is a leading cause of death and chronic disabilities. Evolving surgical techniques and advancements in chest wall reconstruction have improved clinical outcomes, reduced operative complications, and decreased mortality. In this case report, a 23-year-old male U.
View Article and Find Full Text PDFFront Public Health
December 2024
Center for Health Professions Education, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Introduction: Health provider burnout is highly prevalent (28-51%) in the US and may contribute to a projected national health provider shortage by 2030. The Socioecological Model (SEM) is a proven conceptual framework used to identify influencing factors and design relevant solutions to improve health outcomes across multiple ecological levels. This study applied the SEM to identify modifiable drivers and solutions of burnout across multiple levels among US Military health providers.
View Article and Find Full Text PDFPLoS One
December 2024
Medical Readiness Systems Biology, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Rehabilitation from musculoskeletal injuries (MSKI) complicate healing dynamics typically by sustained disuse of bone and muscles. Microgravity naturally allows limb disuse and thus an effective model to understand MSKI. The current study examined epigenetic changes in a segmental bone defect (SBD) mouse model in a prolonged unloading condition after spaceflight (FLT).
View Article and Find Full Text PDFMethods Mol Biol
December 2024
Viral Immunology Branch, United States Army Medical Research Institute of Infectious Disease, Frederick, MD, USA.
Quantitative real-time PCR (qPCR) is a fast and reliable method to quantify viral genomes as a surrogate to titering on monolayers of cells for measuring virus replication. Whether it be for determining the number of virions released, the total number of genomes produced during infection, or the number of virions bound to a cell, qPCR assays can be adapted to quickly enumerate total viral genomes in a broad range of experiments comparing virus replication under different conditions. In addition, qPCR offers several advantages compared to plaque assays including time, linearity over 9 logs, and scalability from tens-to-hundreds of samples, depending on the qPCR machine.
View Article and Find Full Text PDFOrphanet J Rare Dis
November 2024
Psychological Aspects of Cancer, Danish Cancer Institute, Strandboulevarden 49, Copenhagen, 2100, Denmark.
Oncogene
November 2024
MicroQuin, Cambridge, MA, USA.
Transmembrane B cell lymphoma 2-associated X protein inhibitor motif-containing (TMBIM) 6, also known as Bax Inhibitor-1 (BI-1), has been heavily researched for its cytoprotective functions. TMBIM6 functional diversity includes modulating cell survival, stress, metabolism, cytoskeletal dynamics, organelle function, regulating cytosolic acidification, calcium, and reactive oxygen species (ROS). Clinical research shows TMBIM6 plays a key role in many of the world's top diseases/injuries (i.
View Article and Find Full Text PDFbioRxiv
November 2024
U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Elimination of latent HIV-1 is a major goal of AIDS research but the host factors determining the size of these reservoirs are poorly understood. Here, we investigated whether differences in host gene expression modulate the size of the HIV-1 reservoir during suppressive ART. Peripheral blood mononuclear cells (PBMC) from fourteen individuals initiating ART during acute infection who demonstrated effective viral suppression but varying magnitude of total HIV-1 DNA were characterized by single-cell RNA sequencing (scRNA-seq).
View Article and Find Full Text PDFNat Commun
November 2024
McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nanomedicine (Lond)
December 2024
Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Aims: To develop a novel nanomicelle system to target and eradicate CD133-expressing lung cancer stem cells (CSCs) while imaging lung cancer.
Methods: Averatinib nanomicelles with CD133 aptamers incorporated with gadolinium imaging reagents (M-Afa&Gd-CD133) were synthesized. The anticancer and imaging activities of M-Afa&Gd-CD133 were evaluated both in vitro and in vivo.
Front Nutr
November 2024
Department of Cardiovascular Medicine, Air Force Medical Center, Chinese People's Liberation Army, Beijing, China.
Background And Objective: Albuminuria is an important early marker of kidney damage and progression of chronic kidney disease and is also linked to several chronic systemic diseases. The Prognostic Nutritional Index (PNI) is widely used in the assessment of multiple diseases. However, research dealing with the relationship between PNI and albuminuria remains scarce.
View Article and Find Full Text PDFEur Burn J
December 2023
Joint Trauma System, DoD Center of Excellence for Trauma, Joint Base San Antonio-Fort Sam, Houston, TX 78234, USA.
Throughout history, seafarers have been exposed to potential thermal injuries during naval warfare; however, injury prevention, including advances in personal protective equipment, has saved lives. Thankfully, burn injuries have decreased over time, which has resulted in a significant clinical skills gap. Ships with only Role 1 (no surgical capability) assets have worse outcomes after burn injury compared to those with Role 2 (surgical capability) assets.
View Article and Find Full Text PDFEur Burn J
January 2024
Department of Surgery, University of Washington, Seattle, WA 98195, USA.
Burn injuries are a constant threat in war. Aspects of the modern battlefield increase the risk of burn injuries and pose challenges for early treatment. The initial resuscitation of a severely burn-injured patient often exceeds the resources available in front-line medical facilities.
View Article and Find Full Text PDFEur Burn J
May 2024
U.S. Army Institute of Surgical Research Burn Center, 3698 Chambers Pass, JBSA, Fort Sam Houston, TX 78234, USA.
Eur Burn J
March 2024
US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA.
As mortality relating to severe acute burn injury improves, patients are surviving longer into the critical care phase, which is commonly complicated by multisystem organ failure. Extracorporeal organ support (ECOS) represents a set of potential therapeutic technologies for managing patients with organ-specific complications. This article provides a comprehensive review of the existing literature, focusing on the use of continuous kidney replacement therapy, extracorporeal membrane oxygenation, extracorporeal carbon dioxide removal, and extracorporeal blood purification.
View Article and Find Full Text PDFAm J Emerg Med
November 2024
Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, United States.
BMC Med
November 2024
School of Medicine, Nankai University, Nankai District, 94 Weijin Road, Tianjin, 300071, China.
Background: Failure of systemic corticosteroid therapy is common in patients with newly diagnosed acute graft-versus-host disease (aGVHD) above grade II. Mesenchymal stem cells (MSCs) have been used as a tolerable and potentially effective second-line therapy for steroid-refractory aGVHD (SR-aGVHD); however, well-designed, prospective, controlled studies are lacking.
Methods: This multicentre, randomized, double-blind, placebo-controlled, exploratory phase 2 study enrolled patients with SR-aGVHD above grade II from 7 centres.
PLoS One
November 2024
Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital, Army Medical University, Chongqing, China.
Objectives: The relationship between statin treatment and fracture risk is still controversial, especially in in patients with cardiovascular diseases (CVDs). We aim to determine whether statin therapy affects the occurrence of fractures in the general US population and in patients with CVDs.
Methods: Epidemiological data of this cross-sectional study were extracted from the National Health and Nutrition Examination Survey (NHANES, 2001-2020, n = 9,893).
Pediatr Crit Care Med
January 2025
Division of Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT.
Objectives: We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%.
Design: A prospective, quality improvement (QI) initiative utilizing the Method for Improvement.
Burns
October 2024
United States Army Institute of Surgical Research, Fort Sam Houston, TX, USA. Electronic address:
Background: Many research-based burn models rely on creating homogenous burns that are subsequently studied and treated. However, the majority of burn wounds sustained - and in particular those that are combat-related - are heterogeneous in nature, with varying degrees of severity intermixed throughout the entire wound, creating a complex debridement and overall treatment plan. The purpose of this study was to develop a clinically relevant heterogeneous porcine burn wound model.
View Article and Find Full Text PDFLab Anim (NY)
December 2024
Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Lurie Center for Autism, Charlestown, MA, USA.
The translational value of the marble burying task (MBT) is debatable. Here we performed video analysis of behaviors during the MBT to accurately capture the details of all behaviors displayed during this task. Our results show that a count of marbles buried at the end of the task may not be a good translational correlate of the 'intentional marble burying' that the task is assumed to measure.
View Article and Find Full Text PDFPLoS Negl Trop Dis
November 2024
Truhlsen Eye Institute, Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Background/objectives: Ebola virus disease (EVD) survivors develop post-acute ophthalmic sequelae, including a high prevalence of uveitis that may be complicated by vision-threatening cataract. After the non-detection of Ebola virus (EBOV) RNA in sampled ocular fluid, vision impairment due to cataract can be treated safely and effectively via manual small incision cataract surgery (MSICS). However, the long-term ocular visual outcomes and assessment of ocular tissues, including for genomic RNA, have been infrequently or not reported in Western African survivors.
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