Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: signature of altered neural development?

The development of the human neocortex gives rise to a complex cytoarchitecture, grouping together cells with similar structure, connectivity and function. As a result, the six neocortical laminae show distinct molecular content. In schizophrenia, many anatomical and neurochemical changes appear to be restricted to a subset of lamina and/or cell types.

Management of advanced cancers of the external nose.

Advanced carcinoma of the external nose is almost always associated with prior inadequate therapy. The first principle, therefore, in managing cutaneous malignancies of the nose is to achieve adequate tumor-free removal at the initial treatment. Recurrent carcinoma of the nose may require either hemirhinectomy or total rhinectomy to achieve tumor control.