Adeno-Associated Viral Vectors in the Treatment of Epilepsy.

Epilepsy is a brain disorder characterized by a persistent predisposition to epileptic seizures. With various etiologies of epilepsy, a significant proportion of patients develop pharmacoresistance to antiepileptic drugs, which necessitates the search for new therapeutic methods, in particular, using gene therapy. This review discusses the use of adeno-associated viral (AAV) vectors in gene therapy for epilepsy, emphasizing their advantages, such as high efficiency of neuronal tissue transduction and low immunogenicity/cytotoxicity.

Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases.

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured.

The Impact of Treadmill Training on Tissue Integrity, Axon Growth, and Astrocyte Modulation.

Spinal cord injury (SCI) presents a complex challenge in neurorehabilitation, demanding innovative therapeutic strategies to facilitate functional recovery. This study investigates the effects of treadmill training on SCI recovery, emphasizing motor function enhancement, neural tissue preservation, and axonal growth. Our research, conducted on a rat model, demonstrates that controlled treadmill exercises significantly improve motor functions post-SCI, as evidenced by improved scores on the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and enhanced electromyography readings.

The role and clinical relevance of long non-coding RNAs in glioma.

Glioma represents a complex and heterogeneous disease, posing significant challenges to both clinicians and researchers. Despite notable advancements in glioma treatment, the overall survival rate for most glioma patients remains dishearteningly low. Hence, there is an urgent necessity to discover novel biomarkers and therapeutic targets specifically tailored for glioma.

[Pilot study of the manifestations of synchrony of the anatomical-metabolic and functional state of the brain, kidneys and bladder].

Unlabelled: im. The results of clinical observations and scientific studies of recent years indicate that abstinence from urination before the introduction of radiopharmaceuticals for PET / CT procedures is accompanied by a significantly lower flow of it into the bladder than after preliminary urination.

Purpose Of The Study: Comparative analysis of PET/CT metabolism of 18F-fluorodeoxyglucose at the level of the cingulate gyrus of the brain, different regions of the kidney parenchyma and in the bladder wall in individuals without nephrourological history, depending on the phase of the functional state of the bladder.

[The second stage of rehabilitation of post-infectious myelopathy after a new coronavirus infection].

Unlabelled: After suffering a new coronavirus infection (COVID-19), patients develop damage to various organs and systems, including the central nervous system. One of the rare and little-described complications is spinal cord injury.

Purpose Of The Study: Description of a clinical case of post-infectious myelopathy in a young patient after a new coronavirus infection.

[The results of quantitative assessment of the level of adherence to treatment in patients of dental medical organizations].

Objective: To determine the level of adherence to treatment in patients applying to dental organizations of different forms of ownership.

Material And Methods: 1.067 patients of both sexes and various ages who applied to public and private dental organizations of Moscow, Omsk, and Tyumen have been surveyed using the Questionnaire for Quantitative Assessment of Adherence to Treatment (KOP-25), which allows to obtain a quantitative evaluation of the level of adherence to drug treatment, medical support, lifestyle modification, and characterize the level of integral adherence to treatment in patients.

[Predictors of acute heart failure in patients with ST-segment elevation myocardial infarction of the electrocardiogram after PCI].

Background: Despite the PCI in patients with ST-segment elevation myocardial infarction (STEMI) the development of acute heart failure (AHF) Killip ≥II is associated with a poor prognosis.

Aim: To identify predictors of the development of AHF and the prognostic value of AHF in patients with STEMI after PCI.

Materials And Methods: In a prospective study, which lasted 6 months, included 233 patients (average age of 62.

[Contrast-Induced Acute R enal Injury After Percutaneous Coronary InterventionI in Patients With ST-Segment Elevation Myocardial Infarction].

Aim: To assess frequency and prognostic value of contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI).

Materials And Methods: We included in this prospective observational study 233 patients with STEMI. Duration of follow-up was 6 months.

[Duration and Timing of Initiation of Therapy With Platelet P2Y12 Inhibitors in the Treatment of Patients With Acute Coronary Syndrome].

In recent years, the issues of choice of an agent for dual antiplatelet therapy (DAPT) as well as timing of initiation and duration of DAPT in patients with acute coronary syndrome (ACS) have been actively discussed. In this article we present data of major randomized trials of clopidogrel and novel P2Y12 inhibitors - prasugrel, ticagrelor, cangrelor - assessing strategy of administration of antiaggregants in patients with ACS before coronary angiography / percutaneous coronary intervention. The article also contains analysis of differences between recommendations of the European Society of Cardiology and American College of Cardiology/American Heart Association on therapy with oral P2Y12 inhibitors in the management of patients with ACS.

[Elevated Level of the Natriuretic Peptide Among Adult Population in Regions Participating in the ESSE-RF Study and Its Association With Cardiovascular Diseases and Risk Factors].

Aim: to study associations between elevated blood plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP), risk factors and cardiovascular diseases (CVD) in samples of adult population of Russian Federation (RF) aged 25-64 years.

Materials And Methods: We analyzed data of examination of representative samples of population of 5 regions of RF obtained within the framework of the multicenter ESSE-RF study (2012-2013). Number of examined subjects was 8 077 (3 176 men).

[Comparison of Direct Stenting Versus Stending After Pre-Dilation in ST-Elevation Myocardial Infarction].

Aim: To study was to assess in-hospital outcomes of direct coronary stenting (DS) compared with stenting after predilation (PD) in patients with ST-elevation myocardial infarction (STEMI).

Material And Methods: Data were collected from all patients (n=1103) with STEMI subjected to primary PCI in Tyumen cardiology center from 2006 to 2014. The clinical and angiographic characteristics, in-hospital outcomes, as well as predictors of no-reflow phenomenon were analyzed.