[The reference values of 17-hydroxyprogesterone and dehydroepiandrosterone in the gestational period].

Hyperandrogenism has a considerable negative impact on the course of pregnancy. The measurement of the levels of 17-hydroxy-progesterone and dehydroepiandrosterone sulfate as markers of adrenal hyperandrogenism, without taking into account the gestational metabolism of the hormones, promotes the hyperdiagnosis of nonclassical forms of congenital adrenal cortex dysfunction and involves inadequate treatment policy. The isolated elevation of dehydroepiandrosterone sulfate is not attended by an increase in the incidence of androgen-dependent complications of pregnancy.

[Screening for congenital adrenal hyperplasia in pregnancy: results and perspectives].

The purpose of the present study was to study the time course of changes in the levels of dehydroepiandrosterone sulfate (DHEAS) and 17-hydroxyprogesterone (17-HOP) in pregnant women in relation to the gestational time from the results of the screening made in Tyumen. The study analyzed 2,817 medical charts of pregnant women. The levels of DHEAS and 17-HOP had been determined in 1,485 (52%) and 230 (8.