907 results match your criteria: "Type 2 Diabetes and TCF7L2"
Dysregulated Vitamin D, , , and Δ32 Gene Variations are Associated with Coronary Artery Disease.
Discov Med
November 2024
Department of Medical Lab Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, 71491 Tabuk, Saudi Arabia.
Article Synopsis
- - Insufficient vitamin D levels are linked to chronic conditions like cancers, diabetes, and cardiovascular diseases, particularly coronary artery disease (CAD), with enzymes involved in vitamin D metabolism potentially affecting these levels.
- - The study analyzed genetic mutations (rs1562902 C > T, rs12255372 G > T, and Δ32 bp deletion) for their relationships with reduced vitamin D and CAD risk, using specific PCR techniques for genotyping.
- - Results showed significant associations between certain genetic variants and higher CAD risk, particularly the rs1562902 C > T genotype and Δ32 deletion, suggesting these mutations may be genetic indicators for CAD susceptibility.
Single nucleotide polymorphisms (SNPs) that are associated with obesity and type 2 diabetes among Asians: a systematic review and meta-analysis.
Sci Rep
August 2024
Department of Public Health Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000, Kuala Lumpur, Malaysia.
Article Synopsis
- * The study focused on summarizing SNPs linked to these conditions specifically in Asian populations, as fewer studies have investigated this compared to Western populations.
- * Key SNPs associated with obesity include rs9939609 and rs17782313 (FTO and MC4R genes), while T2DM is linked to SNPs like rs7903146 and rs12255372 (TCF7L2 gene), indicating the potential for gene screening in assessing risk for these diseases.
Pesticide-induced transgenerational alterations of genome-wide DNA methylation patterns in the pancreas of Xenopus tropicalis correlate with metabolic phenotypes.
J Hazard Mater
October 2024
Science for Life Laboratory, Department of Environmental Science, Stockholm University, Stockholm, Sweden. Electronic address:
Article Synopsis
- The text discusses the negative impact of manmade chemicals, particularly the herbicide linuron, on biodiversity and human health, focusing on its transgenerational effects.
- The study examines how linuron exposure affects DNA methylation patterns in the pancreas of male Xenopus tropicalis frogs, revealing significant changes in genes crucial for metabolic health and pancreatic function.
- The findings indicate that environmental contamination can lead to lasting metabolic disturbances, highlighting the potential health risks linked to pesticide exposure across generations.
Investigation of genetic markers associated to type 2 diabetes mellitus in Santarém-Pará.
Genet Mol Biol
August 2024
Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Article Synopsis
- Genetic, epigenetic, and environmental factors contribute to the development of Type 2 Diabetes Mellitus (T2D), with specific focus on gene variants known as Single Nucleotide Polymorphisms (SNPs).
- This study aimed to explore the relationship between certain SNPs (in the ADRB3, ABCC8, TCF7L2, and FTO genes) and T2D risk in a population from Santarém, Brazil.
- The findings highlighted a significant association between the ABCC8 SNP (rs1799854 C>T) and T2D, as these genes are connected to glucose regulation and body fat management.
A Systematic Review of the Gene-Lifestyle Interactions on Metabolic Disease-Related Outcomes in Arab Populations.
Nutrients
August 2024
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK.
Article Synopsis
- - The rising rates of metabolic diseases like obesity and type 2 diabetes in Arab countries are linked to genetic factors, low physical activity, and poor diet choices.
- - This review analyzed studies on gene-lifestyle interactions to understand how genetics and lifestyle impact these diseases specifically in Arab populations, including five relevant articles from various research sources.
- - Findings revealed 14 interactions between certain genetic variants and lifestyle factors across three of twenty-two Arab populations; however, limitations in sample sizes and study designs hinder the ability to replicate and generalize results.
Assessment of potential genetic markers for diabetic foot ulcer among Moscow residents.
Endocrine
December 2024
National Research Centre Kurchatov Institute, Moscow, Russian Federation.
Article Synopsis
- Diabetic foot ulcers (DFUs) are serious complications of type 2 diabetes, leading to chronic skin ulcers that are difficult and costly to treat; early prediction could help mitigate these issues.
- A study conducted on diabetic patients in the Moscow region evaluated genetic markers (SNPs) linked to DFUs, but results failed to confirm many previous associations.
- Interestingly, a specific variant in the TCF7l2 gene, which is a known type 2 diabetes risk factor, appeared to have a protective effect against DFUs, hinting at the potential complexity of genetic influences versus environmental factors.
Diabetes-associated Genetic Variation in and Its Effect on Islet Function.
J Endocr Soc
July 2024
Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Article Synopsis
- Genetic variation at rs10830963 has been linked to type 2 diabetes, but its specific impact on insulin and glucose regulation is not fully understood.
- This study aimed to evaluate how this genetic variant affects islet function in individuals without diabetes by testing factors like glucose and insulin levels among 294 participants.
- Results indicated that carrying one or two copies of the G-allele at rs10830963 led to higher post-meal glucose and glucagon levels, suggesting it may influence diabetes risk through alterations in α-cell function.
Association of Gene Variant (rs12255372) with Polycystic Ovary Syndrome and its Effect Modification of the Disease Phenotype.
Indian J Clin Biochem
July 2024
Multidisciplinary Research Unit, Department of Clinical Research, SKIMS, Srinagar, India.
Article Synopsis
- Polycystic ovary syndrome (PCOS) and type-2 diabetes mellitus (T2DM) may share genetic traits, but previous studies have not established a clear link between the two, particularly regarding a specific genetic variant, rs12255372.
- In this study, researchers examined 120 women with PCOS against an equal number of control subjects using hormonal profiling and genetic testing to evaluate the association of the rs12255372 variant with PCOS risk.
- The results revealed that women with the heterozygous genotype of rs12255372 had a 2-fold increased risk of developing PCOS, especially in those with family histories of T2DM or symptoms like hirsutism and irregular menstrual cycles.
Identification and correction for collider bias in a genome-wide association study of diabetes-related heart failure.
Am J Hum Genet
July 2024
Atlanta VA Healthcare System, Decatur, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
Article Synopsis
- * A genome-wide association study (GWAS) identified 61 genetic loci associated with HF, and the Mendelian randomization analysis revealed that T2D increases HF risk (OR 1.07) while HF also increases T2D risk (OR 1.60).
- * The study further corrected for collider bias in diabetes-related HF, finding significant genetic associations near the PITX2 and CDKN2B-AS1 genes, highlighting the importance of addressing collider bias to uncover true genetic links.
The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.
Diabetes
September 2024
Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Article Synopsis
- * A study of 128 participants examined changes in islet function over three years, comparing those with the TT genotype (linked to diabetes) and a protective allele.
- * Results showed that individuals with the TT genotype experienced worsening glucose tolerance and problems with glucagon suppression, indicating α-cell dysfunction may develop before β-cell issues in the onset of type 2 diabetes.
Correlation between gene expression and certain biochemical parameters in type 2 diabetes mellitus.
J Taibah Univ Med Sci
June 2024
Institute of Genetic Engineering and Biotechnology, University of Baghdad, Baghdad, Iraq.
Article Synopsis
- The study examined how the transcription factor 7-like 2 gene relates to type 2 diabetes (T2DM) in different age groups of the Iraqi population.
- They collected blood samples from young T2DM patients (10-35 years), older T2DM patients (40-80 years), and healthy controls (10-65 years).
- Results showed older T2DM patients had higher gene expression than younger ones, which could impact insulin secretion and beta cell function.
Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.
BMC Med Genomics
April 2024
College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Education City, Doha, P.O. Box 34110, Qatar.
Article Synopsis
- * Researchers conducted whole genome sequencing on over 11,000 participants, identifying and replicating several known genetic loci related to T2D, both with and without considering body mass index (BMI).
- * A unique genetic locus specific to the Qatari population was found, and the study suggests that using a mixed ancestry panel for polygenic risk scores was more effective than one based solely on European data.
[One perspective of the genetic correlations between obesity, type 2 diabetes and cancer].
Orv Hetil
March 2024
5 Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórháza, III. Belgyógyászati Osztály Gyula Magyarország.
Haplotype-based association study of TCF7L2 gene variants with the development of diabetic retinopathy in an Iranian population.
Ophthalmic Genet
June 2024
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Article Synopsis
- Diabetic retinopathy (DR) is a common complication of diabetes, and the study aimed to explore the relationship between specific variants of the TCF7L2 gene and DR in Type 2 diabetes patients.
- The research involved analyzing DNA from 524 Type 2 diabetes patients, of which 290 had DR and 234 did not, using genetic testing methods and evaluating clinical characteristics.
- Results showed that, despite significant differences in clinical factors like blood sugar and family history of diabetes, the TCF7L2 gene variants did not show a significant association with DR in this Iranian population, suggesting possible different roles in other populations.
Pharmacoinformatics approach for type 2 diabetes mellitus therapeutics using phytocompounds from genus: an investigation.
J Biomol Struct Dyn
March 2024
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India.
Article Synopsis
- Type 2 Diabetes Mellitus (T2DM) is a major global health issue, especially in India, prompting researchers to look for alternative treatments beyond current drug therapies.
- This study focuses on anti-diabetic compounds from a plant known as the insulin plant, using bioinformatics to identify effective therapeutic compounds and key genes associated with T2DM.
- Key findings include three potent compounds—stigmasterol, cycloartenol, and diosgenone—showing strong binding to important target proteins, and the research suggests these could be promising candidates for future drug development in treating T2DM in the Indian population.
Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.
Bull Exp Biol Med
February 2024
Tyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
Article Synopsis
- A study analyzed the genetic variants rs7903146 of the TCF7L2 gene and rs1801282 of the PPARG gene in 64 Tyumen citizens aged 40-70, focusing on their relationship with metabolic parameters and insulin resistance.
- The researchers found that homozygous carriers of the C allele for rs7903146 had higher C-peptide levels and associations with increased waist circumference, elevated glycated hemoglobin, and hypertension.
- For the rs1801282 variant, homozygous carriers of the C allele showed higher triglyceride levels and similar associations with waist circumference and glycated hemoglobin compared to other genotypes.
Association between variants in , , and genes and response to therapy with glucagon-like peptide-1 receptor agonists.
Postgrad Med
March 2024
Division of Endocrinology and Metabolism - Diabetes Center, 1st Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
Article Synopsis
- The study aimed to explore how genetic variations in certain genes affect the response to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in Greek patients with type 2 diabetes mellitus (T2DM).
- It involved 191 patients who had been on GLP-1 RA treatment for over 6 months, and their genetic variants were assessed along with their clinical outcomes like glycemic control and weight loss.
- The findings indicated that the specific genetic polymorphisms did not significantly influence treatment responses, while factors such as being female and having a lower initial weight were associated with better outcomes.
The effects of transcription factor 7-like 2 rs7903146 and paired box 4 rs2233580 variants associated with type 2 diabetes on the therapeutic efficacy of hypoglycemic agents.
Heliyon
March 2024
Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Article Synopsis
- The study investigates how two genetic variants, rs7903146 and rs2233580 (R192H), affect the efficacy of different diabetes treatments in patients with Type 2 Diabetes (T2D) over a 3-year period.
- It involved 526 patients at a clinic, where their genetic makeup was analyzed alongside the success of treatments using a specific testing technique and statistical methods.
- Results showed that patients with certain genotypes had better blood sugar control when treated with particular diabetes medications, highlighting the role of genetics in personalized diabetes treatment strategies.
Conditional Deletion of β-Catenin in the Mediobasal Hypothalamus Impairs Adaptive Energy Expenditure in Response to High-Fat Diet and Exacerbates Diet-Induced Obesity.
J Neurosci
April 2024
Centre for Neuroendocrinology and Department of Anatomy, University of Otago School of Biomedical Sciences, Dunedin 9016, New Zealand
Article Synopsis
- β-Catenin is an important protein involved in Wnt signaling that affects gene expression and cellular processes, linking it to obesity and type-2 diabetes through interaction with TCF7L2.
- * Researchers investigated its role in regulating body weight and glucose levels by deleting β-catenin in specific brain regions in mice, observing their reactions to different diets.
- * Results showed that mice lacking β-catenin gained more weight on a high-fat diet due to lower energy expenditure and exhibited glucose intolerance, suggesting β-catenin's significant role in metabolism and potential links to metabolic diseases.*
Article Synopsis
- Type 2 diabetes mellitus (T2DM) is often caused by insulin resistance and can be influenced by genetic and environmental factors, specifically the TCF7L2 gene polymorphism (rs7903146) linked to increased risk for the disease.
- A study involving 194 T2DM patients and 180 non-diabetic controls found that those with the T allele of the rs7903146 SNP had a nearly two-fold higher risk of developing T2DM.
- Monitoring glycosylated hemoglobin (HbA1c) levels in individuals with this polymorphism is recommended for early T2DM detection and prevention of complications.
Alternative polyadenylation quantitative trait methylation mapping in human cancers provides clues into the molecular mechanisms of APA.
Am J Hum Genet
March 2024
Department of Pathology, and Department of Medical Oncology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; Department of Pathology, Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou, Zhejiang Province, China; Department of Pathology, Research Unit of Intelligence Classification of Tumor Pathology and Precision Therapy, Chinese Academy of Medical Sciences (2019RU042), Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. Electronic address:
Article Synopsis
- Genetic variants play a key role in the regulation of alternative polyadenylation (APA) events, while the impact of DNA methylation on APA is not fully understood.
- Researchers developed a detailed atlas of APA quantitative trait methylation sites (apaQTMs) across various cancer types, identifying strong associations with polyadenylation sites and transcription factor binding regions.
- The study highlights the significant involvement of DNA methylation in regulating APA in human cancers and introduces the Pancan-apaQTM database to facilitate further research into these complex biological interactions.
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing.
CRISPR J
February 2024
Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Article Synopsis
- Researchers created a new CRISPR prime editing method to generate isogenic-induced pluripotent stem cells (iPSCs) with specific genetic changes related to type 2 diabetes.
- They developed a two-step approach to identify the best edited cell pools, which improved the efficiency of isolating individual edited cells.
- The study showed that optimizing design elements and guide RNAs for prime editing led to a success rate of 36-73%, allowing for effective genetic modifications in iPSCs to better study diabetes-related genetic variations.
Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition?
Int J Biol Macromol
March 2024
Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India. Electronic address:
Article Synopsis
- - Type 2 diabetes mellitus (T2DM) is a widespread chronic disease with severe complications, and current anti-diabetic medications struggle to provide effective long-term treatment due to side effects.
- - The Wnt signaling pathway has emerged as a potential new target for diabetes treatment, as it plays a crucial role in glucose regulation and is influenced by genetic factors like polymorphisms in the TCF7L2 gene and mutations in the LRP5 gene.
- - Despite ongoing research, there is still no definitive evidence on whether activating or inhibiting Wnt signaling is more beneficial for T2DM, but the review discusses the challenges and opportunities for developing new anti-diabetic drugs that focus on this pathway.
TCF7L2 and FTO Polymorphisms Are Associated with Type 2 Diabetes Mellitus Risk in Kuwait.
Med Princ Pract
January 2024
Human Genetics Unit, Department of Pathology, College of Medicine, Kuwait University, Jabriya, Kuwait.
Article Synopsis
- The study investigates genetic risk factors for type 2 diabetes mellitus (T2DM) in Kuwait, focusing on the FTO and TCF7L2 variants.
- Researchers genotyped 203 T2DM patients and 162 healthy controls, revealing that specific genetic variants significantly increase T2DM risk in the Kuwaiti population.
- Findings suggest that these genetic factors, which have been observed in other populations, could help improve predictive models for T2DM risk in Kuwait, warranting further research into additional genetic markers.
Genetic contributions to risk of adverse pregnancy outcomes.
Curr Cardiovasc Risk Rep
November 2023
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Article Synopsis
- The review examines how genetic factors contribute to adverse pregnancy outcomes (APOs) and peripartum cardiomyopathy (PPCM), which pose cardiovascular risks for mothers and their babies.
- It highlights findings from genome-wide association studies (GWAS) that connect genetic variations to conditions like hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), and preterm birth (PTB), revealing biological mechanisms behind these issues.
- The study emphasizes the potential for genetic counseling to help individuals affected by APOs or PPCM, given the newly discovered links between specific genetic variants and long-term health risks.