Effects of reading augmented reality storybook versus normal storybook reading on preoperative fear and anxiety levels of children in the age group of 7-12 years: A randomized controlled trial.

Aim And Objectives: In the preoperative period, non-pharmacological methods such as multimedia applications and visual and audio technological tools are used to reduce children's fear and anxiety levels and to distract their attention to create a more enjoyable experience. One of these innovative technologies having attracted attention recently is augmented reality technology. The study was aimed investigating the effects of reading an augmented reality storybook on fear and anxiety levels of children in the age group of 7-12 years in the preoperative period.

Wear behavior of CAD-CAM zirconia, ceramic, and 3D printed nano-hybrid resin crowns for the restoration of primary and permanent molars: An in vitro study.

Statement Of Problem: Early childhood caries is one the world's most common problems in infants and treatment of posterior teeth with esthetic crowns in a low rate of wear on opposite dentition is a challenge for pediatric dentists.

Purpose: The purpose of this in vitro study was to evaluate the wear behavior of the tooth colored crown materials and the opposing teeth in using different esthetic crown materials in the mixed dentition period.

Material And Methods: The following tooth type and crown materials were considered in the experiment.

Motor Learning-based Clinical Pilates Training for the Parkinson's Disease Rehabilitation @Parkinsonpilates: A Parallel Group, Randomised Controlled Trial with 3-Month Follow-up.

Objectives: To examine the effect of integrated motor learning clinical pilates protocol we developed for patients with Parkinson's Disease (pwPD) on providing enduring motor skills in walking, balance, reaction time, cadence, and functional mobility at 3-months follow-up.

Design: A parallel-group, randomized controlled trial (RCT).

Setting: XXX Medical Center, XXX, and XXX Physiotherapy and Rehabilitation Center, Nicosia.

Can apelins guide the diagnosis of coronary artery disease in COPD patients?

Background: Apelins are adipokines known for their anti-inflammatory, vasodilator, and antiatherosclerotic effects. They are involved in the pathogenesis of chronic diseases like chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD).

Objectives: This study aims to investigate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.

IAEA activities to support the member states in the production of targeted alpha therapy radiopharmaceuticals.

Due to the growing interest of International Atomic Energy Agency (IAEA) Member States in implementing targeted radionuclide therapy (TRT) in general, the demand for alpha-emitting radionuclides and radiopharmaceuticals is enormous. As an international platform for peaceful applications of radionuclides, the IAEA has been implementing several activities focusing on the production and quality control of alpha emitters and radiopharmaceuticals as well as capacity building in the field, through Technical Meetings, Workshops, Publications and Conference Supports, IAEA-Coordinated Research Projects (CRP) and Technical Cooperation Program (TC). This review article summarises the IAEA activities on the production and quality control of alpha emitter radiopharmaceuticals for targeted alpha therapy (TAT) and a roadmap to future steps including but not limited to the ongoing CRP on Ac-radiopharmaceuticals.

Phthalates in diapers: Assessment of dermal exposure of babies and environmental phthalate release.

In the current study the presence of selected phthalates in diapers used in Türkiye and release of phthalates through baby diapers into waste disposal sites were investigated. Targeted phthalates were analyzed in three different layers of a total of 39 diaper samples sold in the Turkish market. Butyl benzyl phthalate (BBP), Diethyl phthalate (DEP) and Di-n-butyl phthalate (DnBP) were detected in all three layers of diapers.

In silico identification of multidrug resistance gene (MDR)-targeted transposon miRNAs in human cancer.

miRNAs are small RNA molecules that regulate gene expression and play important roles in various biological processes in cells. The discovery of miRNAs is also of great importance in cancer research. miRNAs enable the development of new approaches in cancer treatment by regulating gene expression in cancer cells and have an important place in cancer development, treatment, and diagnosis.

Anti-cancer effects of boron derivatives on non-small cell lung cancer.

Lung cancer is the most frequently diagnosed cancer globally, with 2.5 million new cases representing 12.4 % of the total number of new cases.

Children's fear, pain, and anxiety before and after enema: A descriptive, cross-sectional study.

Aims And Objectives: The study aimed to determine the fear, pain, and anxiety levels of children aged 7-18 years before and after enema.

Method: This descriptive and cross-sectional study was conducted between January 8 and May 3, 2024. STROBE guidelines were followed in the study.

N95 mask usage in children with type 1 diabetes mellitus: Does it affect clinical outcomes?

Background: The global COVID-19 pandemic has necessitated the widespread use of N95 masks, yet their impact on children with chronic conditions like type 1 diabetes (T1DM) remains underexplored.

Objective: This study investigates the effects of N95 mask usage on clinical outcomes in children with T1DM.

Methods: This study enrolled 34 children aged 10-18 with T1DM.

Anticancer potential of Bellardia trixago quantum dots: Cytotoxic effects on various cancer cell lines.

This study investigates the synthesis, characterization, and anticancer effects of carbon quantum dots (CQDs) derived from Bellardia trixago. The CQDs were analyzed using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). TEM results revealed that the CQDs have a spherical morphology and exhibit a layered structure.

Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect.

A series of 6,7-dimethoxy-4-anilinoquinazoline derivatives, which have amidine (4a-4d, 5a-5c, 6a-6d) and amidoxime (4e, 5d, 6e) moieties, were synthesized and evaluated their anticancer activity on various cancerous cell lines (H1975, HCC827, and H23). Among the synthesized compounds, 4c was found to be the most potent inhibitor of EGFR, comparable to erlotinib, with higher than 10 μM EC values for H1975 and H23 and 0.16 μM EC value for HCC827 cells.

Greening road transport: Comparison of technologies in conventional, hybrid, and electric vehicles.

The transportation sector is the primary catalyst for environmental deterioration on a global level. Growing concerns about environmental issues caused by the overuse of fossil fuels in this industry have prompted countries to prioritize eco-friendly and energy-efficient vehicles. Electric and hybrid vehicles offer a potential solution to the global challenge of meeting carbon neutrality objectives, especially in the transportation sector.

Astracondensatol D: A 6/6/5/6 Cycloartane Triterpenoid from .

Astracondensatol D (), a pentacyclic triterpenoid featuring an uncommon 6/6/5/6-fused ring system, along with its precursor astracondensatol E (), and two simplified 20(27)-octanorcycloastragenol derivatives ( and ) were isolated from for the first time. Classical NMR spectroscopic data, integrated with NMR and DP4+ calculations, unambiguously determined their absolute stereostructures. X-ray crystallography provided independent confirmation of the structure of compound .

FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in .

There is great interest in using genetically tractable organisms such as to gain insights into the regulation and function of sleep. However, sleep phenotyping in has largely relied on simple measures of locomotor inactivity. Here, we present FlyVISTA, a machine learning platform to perform deep phenotyping of sleep in flies.

Antibiotic residues in animal products in Hatay, Turkey.

There are many studies, both abroad and in Turkey, on the detection of antibiotic residues in animal products. However, studies on this subject in the Hatay region are rare. Within the scope of this study, the presence of 14 types of antibiotic residues (ampicillin, amoxycillin, demeclocycline, doxycycline, enrofloxacin, chlortetracycline, novobiocin, oxytetracycline, penicillin G, streptomycin, sulphadimethoxine, sulphamethazine, tetracycline, and tylosin) in samples from animal products such as beef, poultry, milk, and eggs sold unbranded in Hatay were investigated using HPLC.

Pharmacist interventions in optimising opioid medication therapy in pain management for palliative care patients: A systematic review.

BackgroundOpioid therapy is a critical component in managing pain in palliative care, where pharmacists' specialised expertise is crucial in ensuring quality care for patients. This systematic review aims to document available evidence on pharmacist interventions and their impact on optimising opioid therapy for pain management in palliative care patients.MethodsWe searched Medline (OVID), Embase (OVID), APA PsycINFO and Cochrane Central Register of Controlled Trials (CENTRAL) for relevant articles published from the beginning to 31 December, 2022.

Dark Triad and Resilience to Personal Loss: Evidence from the 2023 Türkiye-Syria Earthquakes.

Can narcissism help foster resiliency against adversity? In this study, we used Turkish panel data, to examine whether narcissism can buffer the negative impact of personal loss on change in subjective well-being in the wake of the Türkiye-Syria earthquakes of 2023. Results show that the adaptation to personal loss was stronger for individuals high on narcissism. At the same time, we found no evidence that individuals high on Machiavellianism or psychopathy - other Dark Triad traits - were better able to adapt to personal loss.

Individualized Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% Administration in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: The Nurse's Role.

Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% offers potential improvements in patient independence and tolerability versus intravenous immunoglobulin (IVIG) when used for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). fSCIG 10% also requires less frequent infusions and fewer infusion sites than conventional subcutaneous immunoglobulin (subcutaneous immunoglobulin without hyaluronidase). The ADVANCE-CIDP 1 study demonstrated fSCIG 10% efficacy and safety in preventing CIDP relapse and positive responses from patients in terms of satisfaction and treatment preference.

Effects of HLA-DRA, HLA-DQA1 and IL-6 Gene Variations to Glatiramer Acetate Resistance in Multiple Sclerosis Patients.

Multiple sclerosis (MS) is among the most common autoimmune disorders and is characterized by inflammation and degeneration affecting the central nervous system. Glatiramer acetate (GA) is an immunomodulatory drug utilized for treating relapsing-remitting MS. However, a considerable number of patients do not exhibit an appropriate response to this drug.

Environmental hazards of light cigarette butts and filters: physiological, cytotoxic, and genotoxic assessment using the Allium cepa L. assay.

Cigarette butts are a common form of litter that pose significant ecological risks due to their toxic components, which can accumulate in soils, impacting human health, plant growth, and soil-dwelling organisms. This study investigated the environmental implications of "light" cigarette butts, which, like regular ones, contain harmful chemicals that render them hazardous waste. The cellulose acetate filters are notably resistant to biodegradation, allowing them to persist in the environment and leach toxins.

Evaluation of the effects of bisphosphonate therapy on the temporomandibular joint using cone beam computed tomography.

Objective: The aim of this study was to evaluate the mandibular condyle and articular eminences of patients diagnosed with medication-related osteonecrosis of the jawbone (MRONJ) and those who use bisphosphonates (BP) but do not have MRONJ findings, by comparing them with a healthy control group.

Methods: The cone beam computed tomography (CBCT) images of 20 patients (15 male, 5 female) who were diagnosed with MRONJ and 20 patients (16 male and 4 female) who were using bisphosphonates but had no MRONJ were included in the study. A control group consisted of 20 age- and gender-matched patients (13 male, 7 female) who had no clinical complaints or signs and symptoms of TMD or rheumatic disease.

Atrial and ventricular strain changes after transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: a feature tracking cardiac MRI study.

Purpose: In patients with repaired tetralogy of Fallot, transcatheter or surgical pulmonary valve replacement is recommended. However, it is not clear whether pulmonary valve replacement preserves systolic and diastolic functions of both ventricles. The aim of the study is to investigate the impact of transcatheter pulmonary valve replacement on atrial and ventricular myocardial strain changes by feature-tracking cardiac magnetic resonance imaging.