Increased systemic oxidative stress in patients with keratoconus.

Purpose: To establish the effect of systemic oxidative stress on the pathogenesis of keratoconus by measuring serum total oxidant status (TOS) and total antioxidant status (TAS) in patients with keratoconus.

Methods: Twenty-five patients with keratoconus (keratoconus group) and 25 age-sex-matched healthy subjects (control group) were enrolled in the study. Exclusion criteria were smoking habit, history of any other corneal pathology, systemic disease or inflammation, and current antioxidant or anti-inflammatory therapies.

Factors affecting outcomes of corneal collagen crosslinking treatment.

Purpose: To assess the effects of preoperative patient characteristics on clinical outcomes of corneal crosslinking (CXL) treatment in patients with progressive keratoconus.

Methods: This retrospective study comprised 96 eyes of 96 patients who had unilateral CXL treatment for progressive keratoconus. All patients underwent a complete ophthalmological examination and corneal topography at baseline and 1 year.

Effects of corneal collagen crosslinking on corneal topographic indices in patients with keratoconus.

Objectives: To evaluate the effects of corneal crosslinking (CXL) on corneal topographic indices in patients with progressive keratoconus using Scheimpflug imaging system.

Methods: This retrospective study comprised 59 eyes of 47 patients who underwent CXL treatment for confirmed progressive keratoconus. Changes in corrected distance visual acuity (CDVA, logMAR equivalent), maximum keratometry (K), and corneal topographic indices included index of surface variance (ISV), index of vertical asymmetry, keratoconus index, center keratoconus index (CKI), index of height asymmetry (IHA), index of height decentration, and minimum radius of curvature (Rmin) were analyzed at 1-year follow-up.