Effects of miRNAs in inborn error of metabolism and treatment strategies.

Metabolism is the name given to all of the chemical reactions in the cell involving thousands of proteins, including enzymes, receptors, and transporters. Inborn errors of metabolism (IEM) are caused by defects in the production and breakdown of proteins, fats, and carbohydrates. Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules, ⁓19-25 nucleotides long, hairpin-shaped, produced from DNA.

Stigma, Depression, and Attitudes Towards Seeking Psychological Help Among Nurses: The Role of Personal Stigma as an Inconsistent Mediator.

Rationale: Identifying whether perceived stigma or personal stigma more significantly affects nurses' attitudes towards seeking psychological help is essential for effectively addressing current challenges and facilitating early intervention for the well-being of nurses and their patients.

Aims And Objectives: The aim of this study was to explore the mediating roles of personal stigma and depression in the relationship between perceived stigma among nurses and their attitudes towards seeking psychological help.

Methods: The sample of this descriptive cross-sectional study consisted of 302 nurses working in a university hospital in southern Turkey, selected using the purposive sampling method, between April 1 and May 1, 2021.

A medical trailblazer in the Ottoman Empire: The legacy of Dr Caroline Frances Hamilton (1861-1944).

This article explores the life and work of Dr Caroline F. Hamilton, one of the pioneering female physicians sent from the USA to the Ottoman Empire in the late 19th century. Over a career spanning three decades, Hamilton provided critical medical care, especially to women, at the Azariah Smith Memorial Hospital in Aintab, overcoming legal, cultural, and political obstacles to become one of the first women licensed to practise medicine in the region.

Growth suppressing effect of extracts on cancerous cell line.

Homeostasis of tissues requires a complex balance between cell proliferation and cell death. The disruption of this balance leads to tumors. Cancer is a mortal disease that spreads all over the body, it is an irregular cell growth.

Investigation of and in Pakistan, with notes on the detection of tickborne Rickettsiales.

There is limited information on the occurrence of and ticks, as well as associated and species in Pakistan. Addressing this knowledge gap, the current study aimed at morphomolecular confirmation of these ticks and molecular assessment of associated Rickettsiales bacteria (, and spp.) in Balochistan, Pakistan.

Phytochemical Profiling by UHPLC-ESI-MS/MS, In Vitro Antioxidant, In Vivo Antidiabetic, and Pro-Sexual Effects of Salvia balansae Noë ex Coss Flower Extract in Diabetic Male Rats.

Our study assessed the phytochemical composition and the effects of Salvia balansae flower aqueous extract (FAE) on sexual dysfunction in diabetic rats. Total phenolic and flavonoid content, quantification of phytochemicals by UHPLC-ESI-MS/MS method and in vitro antioxidant capacity of FAE extract were elucidated. For the in vivo study, diabetes was induced by one intraperitoneal injection of streptozotocin (STZ) (40 mg/kg), and treated diabetic rats were given FAE at 200 mg/kg.

Comprehensive Analysis of Elemental and Metabolite Composition in Boraginaceae Species from Türkiye.

Boraginaceae plants, including four endemic species from Türkiye, were analyzed for organic and inorganic compositions using ICP-MS and LC-MS/MS to explore their nutritional, medicinal, and ecological significance. This study examined 18 species, identifying key elements such as sodium (87,600.359-118,049.

How are the Attitudes Towards Aging and Aging and Death Anxiety in Individuals Over 65 Years of Age With Chronic Diseases?: A Cross-Sectional and Analytical Study.

This study examined the relationship between attitudes toward aging and death anxiety in individuals aged 65 and older with chronic diseases. The study involved 169 participants. Data were collected using Personal Information Form, Turkish Death Anxiety Scale (TDAS), and Attitudes toward Ageing and Elderliness Scale (ATAES).

Blood flow restriction combined with nordic hamstring exercise does not impair endothelial function but does not increase neuromuscular activation.

Background: Optimizing hamstring exercises is crucial for injury prevention and performance. This study explored the effects of blood flow restriction (BFR) during Nordic hamstring exercises (NHE) on hamstring muscle activation and vascular function.

Methods: A randomized, single-blind study included 14 healthy, physically active males (mean age: 27.

Perivascular Epithelioid-Cell Tumour of the Bladder: A Case Report.

Background: Perivascular epithelioid-cell tumour (PEComa) is a rare mesenchymal tumour with low malignant potential. PEComa can be found in many organs throughout the body. In the urinary system, it can be found in the prostate, bladder, and kidney.

Analysis of Patients with Urethral Stricture in Kidney Transplant Recipients.

Background: We aimed to assess the rates of urethral stricture in transplant recipients, analyse patients with urethral strictures and present the posttreatment follow-up outcomes.

Methods: Between 2004 and 2023, a retrospective examination was conducted on kidney transplant recipients who underwent removal of ureteral catheters through retrograde cystoscopy at our facility or referred from external centres. The collected data encompassed patient demographics, pre- and posttransplant maximum urinary flow rate, specifics of stenosis, surgical interventions and outcomes from a 1-year follow-up.

Mediating role of psychological well-being in the effect of spirituality on attitudes toward death in the elderly.

Background: Spirituality and psychological well-being are important in shaping attitudes toward death.

Objective: This study was conducted to determine the mediating role of psychological well-being in the effect of spirituality on attitudes toward death in the elderly.

Method: This cross-sectional descriptive study was conducted in a province of Turkey between February 2024 and June 2024 with 467 individuals aged 65 years and older.

The disease burden of earlier and late-onset rheumatoid arthritis on depression and related geriatric syndromes.

Purpose: This study aims to compare the prevalence of depression and related geriatric syndromes in earlier-onset rheumatoid arthritis (EORA) patients, who have experienced prolonged inflammation and medication use, with those with late-onset rheumatoid arthritis (LORA) patients, who often present with an acute and severe course.

Methods: In this multidisciplinary study, patients with EORA and LORA aged 60 and over who were referred to a tertiary rheumatology clinic underwent a geronto-rheumatologic evaluation. Muscle mass and handgrip strength, cognitive function, nutritional status, Fried frailty index, fall history, gait speed, depression according to Geriatric Depression Scale and Insomnia Severity Index were recorded.

Sexual Health, Pleasure, Justice, and Well-Being in People With Rheumatic and Musculoskeletal Diseases: A Scoping Review Protocol.

Introduction: Sexual health, pleasure, justice (equity in sexual rights and experiences), and well-being are crucial determinants of health and life quality, yet often overlooked in the rheumatic and musculoskeletal diseases (RMD) field. However, this topic has received more attention recently, and there is a need to map the current literature to inform the direction of future studies. Hence, this protocol outlines a scoping review to systematically map existing evidence on sexual health in people with RMD, exploring key themes and identifying evidence gaps across multiple dimensions, including sexual well-being, justice and pleasure.

Remarkable results of energy consumption and CO emissions for gasoline and electric powered vehicle.

Increasing concerns about climate change and efforts on reducing reliance on fossil fuels have led to research on electric vehicles for sustainable solutions to increasing energy demands. This study comprehensively analyzes the impact of power plant emissions on the adoption of electric vehicles in relation to air pollution. The main pollutants emitted by power plants and the potential change in emissions with the deployment of electric vehicles are assessed.

'Paediatric Emergency Course' for nursing continuing professional development programme evaluation: ARCS Motivational Design Model.

Background: Paediatric emergency and critical care require skilled nurses, but they often face a lack of motivation during continuing professional development. Motivation-based, engaging activities in training programmes are essential to sustain interest and improve learning outcomes in these high-stress environments.

Aim: This study aims to develop, implement and evaluate the effectiveness of a Paediatric Emergency Course (PEC) using the ARCS (Attention, Relevance, Confidence, Satisfaction) Motivational Design Model to equip nurses with the knowledge and skills needed to manage paediatric patients in emergency and critical care settings.

Aggression in crime and sports: a study on prisoners and amateur combat athletes in Türkiye.

Background: This research focuses on examining and comparing the aggression levels of prisoners incarcerated for intentional injury and amateur combat athletes. The study aims to explore the differences in aggression levels among these groups to understand the impact of incarceration and sports participation on aggression.

Methods: The participants included in the analysis consist of prisoners (n = 363) housed in Marmara No.

The relationships of personality traits on perceptions and attitudes of dentistry students towards AI.

Introduction: Artificial intelligence (AI) has gained significant attention in dentistry due to its potential to revolutionize practice and improve patient outcomes. However, dentists' views and attitudes toward technology can affect the application of AI. This perception and attitude can be affected by the personality traits of individuals.

AST/ALT ratio as a potential predictor of 1-year mortality in elderly patients operated for femoral neck fracture.

Purpose: Hip fractures in elderly individuals are associated with high mortality rates, even with advanced treatment options. Identifying factors correlated with mortality could guide potential preventive strategies. Elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as well as the AST/ALT ratio (AAR), have been associated with mortality in various diseases, but their association with hip fracture mortality remains underexplored.

Metabolic syndrome index measurement tool (MSI): scale development, reliability and validity study.

Aim: Identifying the risks of metabolic syndrome (MetS) can lead to early targeted interventions and thus contribute to improved quality of life by reducing the risk of developing MetS, diabetes or heart disease in the future. We aimed to develop a valid and reliable measurement tool to measure the MetS risk of the population.

Materials And Methods: In the methodological study, an item pool was created by reviewing the literature.

Investigation of the dorsal cutaneous nerve injury risk and portal safety related to wrist surgery: an anatomical study.

The aim of this study was to define the branching patterns and innervation regions of the superficial branch of the radial nerve and the dorsal branch of the ulnar nerve and to evaluate the distance from 1-2, 3-4, 4-5, midcarpal radial, midcarpal ulnar, dorsal radioulnar joint, 6-radial, 6-ulnar dorsal arthroscopy portals to certain landmarks on the dorsal surface of the hand and wrist. Forty hands and wrists of 20 formalin-fixed intact cadavers without any known pathology, surgical scars or trauma were examined in the Macroscopy Laboratory of Ege University Faculty of Medicine, Department of Anatomy. Arthroscopy portals were placed using a dorsal approach to the wrist in the dissection method.

Negative PSMA PET can be used to avoid unnecessary pelvic lymph node dissection in intermediate risk prostate cancer.

Background: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has a high negative predictive value (NPV) in determining lymph node invasion (LNI) in men with intermediate-risk disease undergoing radical prostatectomy (RP) and pelvic lymph node dissection (PLND). We hypothesized that PSMA PET may be used to reduce the number of unnecessary PLND procedures performed.

Objective: To assess BCR-free survival of intermediate risk prostate cancer patients with a negative PSMA PET who underwent PLND vs.

Development of stable and porous AgO-loaded hydroxyapatite nanocomposites for enriched photocatalytic degradation of Rhodamine B under visible light.

A simple and inexpensive process from natural phosphate in the presence of Ag ions was used to develop AgO-loaded hydroxyapatite nanocomposites. The structural and textural characterization of the nanocomposites suggests that the AgO nanoparticles are well dispersed on the hydroxyapatite (HAp). The prepared nanocomposites show efficient Rhodamine B (RhB) dye photocatalytic degradation in water under visible and UV-visible light irradiation.