A medical trailblazer in the Ottoman Empire: The legacy of Dr Caroline Frances Hamilton (1861-1944).

This article explores the life and work of Dr Caroline F. Hamilton, one of the pioneering female physicians sent from the USA to the Ottoman Empire in the late 19th century. Over a career spanning three decades, Hamilton provided critical medical care, especially to women, at the Azariah Smith Memorial Hospital in Aintab, overcoming legal, cultural, and political obstacles to become one of the first women licensed to practise medicine in the region.

Growth suppressing effect of extracts on cancerous cell line.

Homeostasis of tissues requires a complex balance between cell proliferation and cell death. The disruption of this balance leads to tumors. Cancer is a mortal disease that spreads all over the body, it is an irregular cell growth.

Phytochemical Profiling by UHPLC-ESI-MS/MS, In Vitro Antioxidant, In Vivo Antidiabetic, and Pro-Sexual Effects of Salvia balansae Noë ex Coss Flower Extract in Diabetic Male Rats.

Our study assessed the phytochemical composition and the effects of Salvia balansae flower aqueous extract (FAE) on sexual dysfunction in diabetic rats. Total phenolic and flavonoid content, quantification of phytochemicals by UHPLC-ESI-MS/MS method and in vitro antioxidant capacity of FAE extract were elucidated. For the in vivo study, diabetes was induced by one intraperitoneal injection of streptozotocin (STZ) (40 mg/kg), and treated diabetic rats were given FAE at 200 mg/kg.

Testing Machine Learning-Based Pain Assessment for Postoperative Geriatric Patients.

The global population is aging, and there is a concomitant increase in surgery for the elderly. In geriatric patients, where postoperative pain assessment is difficult, technological tools that perform automatic pain assessment are needed to alleviate the workload of nurses and to accurately assess patients' pain. This study offers a more reliable and rapid assessment tool for assessing the pain of elderly patients undergoing surgery.

The ability of the prognostic nutritional index to predict short-term mortality in geriatric acute heart failure.

Background: Heart failure is a critical cardiovascular condition, necessitating comprehensive treatment approaches and contributing to elevated mortality rates. This study aimed to evaluate the effect of the prognostic nutritional index (PNI) on the prognosis of geriatric patients diagnosed with acute heart failure.

Results: A total of 104 patients were included and evaluated retrospectively in this study; 57.

The association between abdominal ultrasound findings and clinical severity in MIS-C children with extracardiac symptoms.

Unlabelled: This study aimed to evaluate pathological findings on abdominal ultrasonography upon admission of children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C) that were associated with a more severe disease course and the need for intensive care unit (ICU) admission. This retrospective and observational study was conducted between March 2020 and May 2022. Abdominal ultrasonography findings were evaluated in children diagnosed with MIS-C associated with SARS-CoV-2.

Anatomical factors behind acquired primary nasolacrimal duct obstruction and acute dacryocystitis.

Purpose: To compare the nasolacrimal and nasal anatomical parameters in cases of acquired primary nasolacrimal duct obstruction and acute dacryocystitis.

Methods: The study included 62 eyes of 31 patients. The eyes were divided into three groups: Group A, comprising eyes presenting with acute dacryocystitis; Group B, comprising eyes with nasolacrimal duct obstruction but no previous episodes of dacryocystitis; and Group C, comprising eyes with an patent nasolacrimal duct.

EVALUATION OF THE EFFECTS OF FAVIPIRAVIR (T-705) ON THE LUNG TISSUE OF HEALTY RATS: AN EXPERIMENTAL STUDY.

Favipiravir, a broad-spectrum RNA-dependent RNA polymerase inhibitor widely used during the COVID-19 pandemic, effectively reduces viral load but has been linked to inflammatory changes in tissues such as the liver and kidneys. High-dose and prolonged use of favipiravir for COVID-19 raises concerns about its potential toxic effects on the lungs, particularly in patients with pre-existing pulmonary conditions. This study investigated favipiravir's effects on lung tissue in healthy rats.

Ethical Use of Cadaveric Images in Anatomical Textbooks, Atlases, and Journals: A Consensus Response From Authors and Editors.

Nowadays, consent to use donor bodies for medical education and research is obtained from the body donors and their families before the donation. Recently, the International Federation of Associations of Anatomists (IFAA) published guidelines that could restrict the appearance of cadaveric images in commercial anatomical resources such as textbooks and other educational products. These guidelines state that the donor must expressly consent to using such images for this purpose.

Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer.

This study aimed to evaluate the diagnostic accuracy of ultrasonography in assessing the response of clipped axillary lymph nodes to neoadjuvant chemotherapy. Between February 2022 and September 2023, 43 patients who underwent axillary lymph node marking for targeted axillary dissection were retrospectively analyzed. Ultrasonography parameters such as the number, size, shape, cortical thickness, hilum status, and treatment response of the clipped lymph node were assessed.

EEFSEC deficiency: A selenopathy with early-onset neurodegeneration.

Inborn errors of selenoprotein expression arise from deleterious variants in genes encoding selenoproteins or selenoprotein biosynthetic factors, some of which are associated with neurodegenerative disorders. This study shows that bi-allelic selenocysteine tRNA-specific eukaryotic elongation factor (EEFSEC) variants cause selenoprotein deficiency, leading to progressive neurodegeneration. EEFSEC deficiency, an autosomal recessive disorder, manifests with global developmental delay, progressive spasticity, ataxia, and seizures.

Conservative management of pediatric pineal cyst apoplexy: a case report and literature review.

A 5-month-old male patient presented with obstructive hydrocephalus caused by pineal cyst apoplexy. Ventriculoperitoneal shunt surgery was performed for hydrocephalus treatment. During follow-up, spontaneous shrinkage of the cyst was observed.

Hajdu-Cheney Syndrome, a Rare Cause of Acro-Osteolysis and Osteoporosis With Zoledronic Acid Experience.

Hajdu-Cheney syndrome (HCS), caused by a heterozygous gain of function variant of the NOTCH2 gene, is a rare skeletal dysplasia. Although the main presentation is acro-osteolysis, osteoporosis, and facial dysmorphism, having a wide range of clinical manifestations creates diagnostic difficulties. Here, a 15-year-old male patient with HCS who had no complaints until this age except for two short bone fractures and one vertebral collapse fracture due to a fall was reported.

Extended PROMETHEE method with (p,q)-rung linear Diophantine fuzzy sets for robot selection problem.

The introduction of (p, q)-rung linear Diophantine fuzzy set into the field of fuzzy set theory is a significant advancement, providing a broader perspective to address complicated decision-making scenarios. Alongside, the preference ranking organization method for enrichment of evaluation (PROMETHEE) emerges as a widely recognized tool for tackling multi-criteria decision-making challenges. This study contributes theoretically to the decision-making field by integrating (p, q)-rung linear Diophantine fuzzy sets into the PROMETHEE framework, improving (p, q)-rung linear Diophantine fuzzy sets adaptability and efficiency in practical aspects, the proposed framework can effectively address various intricate decision-making challenges encountered in real-world scenarios.

Strongyloides stercoralis infection in a patient initiating corticosteroid therapy for hypereosinophilia: A case report.

Strongyloides stercoralis (S. stercoralis) is a soil-transmitted nematode that is endemic to tropical and subtropical regions. S.

Analysis of YouTube Videos on Endotracheal Tube Aspiration Training in Terms of Content, Reliability, and Quality.

This descriptive study aims to investigate the content, quality, and reliability of YouTube videos containing content related to endotracheal tube aspiration. The study was scanned using the keywords "endotracheal aspiration" and "endotracheal tube aspiration," and 22 videos were included in the study. The contents of the selected videos were measured using the Endotracheal Tube Aspiration Skill Form, their reliability was measured using the DISCERN Survey, and their quality was measured using the Global Quality Scale.

Double CHEK2 Pathogenic and Low-Risk Variants and Associated Cancer Phenotypes.

Importance: CHEK2 pathogenic and likely pathogenic variants (PVs) are common, and low-risk (LR) variants, p.I157T, p.S428F, and p.

The triple threat: unpacking the interplay between inflation, government expenditure, energy efficiency, and environmental pollution.

This study investigates the relation and Granger causality among inflation, fiscal expenditure, energy consumption, economic growth, energy efficiency, renewable energy consumption, and environmental pollution in the G7 countries utilizing the PLSTRVAR model for 1975-2022. Our findings highlight the results that inflation and fiscal expenditure have impact on environmental pollution across different regimes. On the other hand, unlike some studies in the literature, it emphasizes that renewable energy consumption may have pollution-increasing effects on environmental pollution.

[Multicentric Screening of Local Antibiotic Resistance in Uncomplicated Urinary System Infections: 1850 Patients from 37 Centers].

This study was aimed to identify the most frequently observed pathogens in uncomplicated urinary tract infections from outpatient urinary isolates obtained across seven different geographical regions in Türkiye and to determine whether the antibiotic resistance rates of these pathogens differ significantly between these regions. The study included patients aged 18 to 65 years who were diagnosed with uncomplicated urinary tract infections and had positive urine cultures from March 2021 to August 2022, across 37 different centers in Türkiye. The participating centers were selected based on their use of the disk diffusion method, in line with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, to ensure standardization of urine culture data.

Efficacy of transbronchial biopsy and frequency of pneumothorax in lung transplant recipients: single center experience.

Objective: Bronchoscopy plays a critical role in the diagnosis and management of lung transplant recipients. We retrospectively evaluated the safety, complications, and efficacy of transbronchial biopsy (TBB) in detecting and grading early rejection.

Materials And Methods: We retrospectively assessed the complications associated with TBB and the adequacy of pathological diagnoses in patients who underwent lung transplantation at Koşuyolu Yüksek İhtisas Training and Research Hospital from December 1, 2016, to April 30, 2023.

Does vitamin D deficiency predispose to allergic proctocolitis?

Objectives: Awareness of vitamin D (vit D) deficiency or insufficiency has increased alongside the rising prevalence of allergic diseases worldwide. We aimed to evaluate vit D levels in infants with allergic proctocolitis (AP) to explore a possible relationship between AP and vit D status.

Methods: This prospective, observational, case-control study was conducted between January 2020 and December 2023, including infants aged 6 months and younger diagnosed with AP (AP group) and healthy infants of the same age (control group).

Neonatal Intensive Care Nurses' Perceptions of Artificial Intelligence: A Qualitative Study on Discharge Education and Family Counseling.

Objective: This study aims to examine neonatal intensive care unit (NICU) nurses' perceptions of artificial intelligence (AI) technologies, particularly language models, and their impact on nursing practices.

Background: AI is rapidly spreading in healthcare, transforming nursing practice. Understanding the role of AI in NICUs in the discharge process is crucial for understanding nurses' perceptions of these technologies.