Reliability and Validity of the Duke Activity Status Index in Bariatric Surgery Individuals Living with Obesity: Insights into Prognostic Value.

Background: Obesity is a global health issue that complicates surgical outcomes, particularly in bariatric/metabolic surgery candidates. Assessing functional capacity is critical for optimizing preoperative planning and postoperative care. The Duke Activity Status Index (DASI) is a simple, self-administered questionnaire that estimates functional capacity based on daily activities.

NELBI score: a new clinical calculator of thirty-day mortality following systemic anticancer therapy in breast cancer patients near the end of life.

Aims And Objectives: Appropriately timed cessation of systemic anticancer treatments is an important part of a patient's quality of life (QoL). We aimed to determine the right time to discontinue systemic anticancer therapy (SACT) and switch to the best supportive care for patients with advanced breast cancer (BC) who are nearing the end of life.

Methods: We identified 200 BC patients who died within 30 days after palliative SACT.

Lifestyle recommendations and pelvic floor muscle training with Knack maneuver for post-prostatectomy urinary incontinence: a randomized controlled trial.

Purpose: The aim of this study is to investigate the additional effects of the Knack maneuver and comprehensive lifestyle recommendations to pelvic floor muscle training (PFMT) in individuals with post-prostatectomy urinary incontinence (PP-UI).

Methods: Seventy-one individuals with symptom of PP-UI were included. Individuals were randomly assigned to study groups (Group I: PFMT + Knack + Comprehensive Lifestyle Recommendations, Group II: PFMT + Knack, Group III: PFMT alone).

DeepLabv3 + method for detecting and segmenting apical lesions on panoramic radiography.

Objective: This study aimed to apply the DeepLabv3 + model and compare it with the U-Net model in terms of detecting and segmenting apical lesions on panoramic radiography.

Methods: 260 panoramic images that contain apical lesions in different regions were collected and randomly divided into training and test datasets. All images were manually annotated for apical lesions using Computer Vision Annotation Tool software by two independent dental radiologists and a master reviewer.

Inadequate sleep hygiene as a key factor in poor sleep quality in systemic sclerosis: an observational, cross-sectional study.

This study aims to investigate the relationship between sleep hygiene and sleep quality in patients with systemic sclerosis (SSc) and to compare the sleep hygiene and sleep quality outcomes across three distinct groups: SSc patients, rheumatoid arthritis (RA) patients, and healthy controls (HC). This study employed an observational, cross-sectional, and parallel group design. SSc-related and RA-related variables, depression and anxiety were assessed.

Investigation of the antibacterial activity, cytotoxicity, and effects on enamel and composite resin of mouthwash formulations prepared with three different Boron compounds.

Objective: This study investigated the use of oral rinse solutions formulated with boron-containing compounds, known for their antibacterial activity, as an alternative to chlorhexidine (CHX).

Material And Method: Boron nitride (BN), boric acid (BA) and sodium borate (SB) were used in the study. BN was used in nanosuspension (BN-NS) due to its low solubility in water.

Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach.

Non-small cell lung cancer (NSCLC) is a widespread highly malignant type of lung cancer. Conventional chemotherapeutic drugs may be accompanied by both drug resistance and serious side effects in patients. Therefore, safer and more effective medications are urgently needed for the treatment of NSCLC.

Versatile roles of disordered transcription factor effector domains in transcriptional regulation.

Transcription, a crucial step in the regulation of gene expression, is tightly controlled and involves several essential processes, such as chromatin organization, recognition of the specific genomic sequences, DNA binding, and ultimately recruiting the transcriptional machinery to facilitate transcript synthesis. At the center of this regulation are transcription factors (TFs), which comprise at least one DNA-binding domain (DBD) and an effector domain (ED). Although the structure and function of DBDs have been well studied, our knowledge of the structure and function of effector domains is limited.

Exploring the anti-inflammatory effects of microencapsulated probiotic bacteria: in vivo and in vitro evaluation in healthy mouse models.

Background: Encapsulation technology has been extensively employed in recent years to enhance the efficacy and efficiency of probiotics. Nevertheless, existing studies have primarily concentrated on product efficacy, with inadequate scrutiny concerning potential effects on living organisms. This study aimed to evaluate the effects of various encapsulated probiotic strains on inflammatory responses in healthy mice, alongside their in vitro viability.

Knowledge, Behaviours, and Attitudes of Family Physicians and Residents About Autism Spectrum Disorder in Turkey: A Descriptive Cross-Sectional Study.

Aim: Autism Spectrum Disorder (ASD) is a growing social health issue. Primary healthcare institutions are where children most commonly seek help, and family physicians in primary care play a crucial role in early ASD detection. This study aims to assess the knowledge level, behaviours, and attitudes of family physicians and family medicine residents across Turkey, identify factors affecting their knowledge, and raise awareness among physicians.

Evaluation of Effects of Verbal and Video-Based Instructions on the Improvement of Oral Hygiene Status in Children: A Randomised Clinical Trial.

Objectives: To evaluate the effects of verbal and video-based oral hygiene instructions (OHIs) on the improvement of the oral hygiene status (OHS) in children of different age groups in the mixed dentition period.

Methods: In total, 202 children aged 6-9 and 10-12 years (n = 101 each) were included. Before providing the OHIs, the baseline OHS was determined using the Simplified Oral Hygiene Index (OHI-S).

Hidradenitis Suppurativa Treatment During Pregnancy and Lactation: Navigating Challenges.

Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin condition primarily affecting skin folds such as the axilla, groins, and the inframammary, perineal, and perianal regions. It is characterized by painful abscesses, sinus tracts, and scarring. Predominantly affecting young adults, particularly females, HS often emerges during reproductive age, and flares are widely reported during pregnancy and postpartum, underscoring the need to consider management strategies tailored to pregnant or lactating individuals.

AS score: a novel score for predicting clinical outcomes in upper gastrointestinal bleeding.

Background: Upper gastrointestinal tract bleeding (UGIB) is an significant cause of admission to emergency departments and hospitalizations.

Aims: The aim of our study was to compare the pre-endoscopic risk scores used in the literature with our new score (AS score) in patients admitted to the emergency department due to upper gastrointestinal bleeding (UGIB).

Methods: A total of 541 patients admitted to the emergency department of a tertiary care hospital due to UGIB were included in the study.

In Vivo Investigation of the Effects of Nonylphenol on the Pituitary-Adrenal Axis and Pineal Gland in Male Rats.

The pineal gland secretes melatonin, which regulates various physiological processes; damage to this gland disrupts these functions. This study aimed to investigate the effect of nonylphenol on the pineal gland and the pituitary-adrenal axis, which is associated with this system. The study was initiated using Wistar albino male rats on their postnatal 21st day, a critical developmental stage for endocrine regulation.

Evaluation of fetal aortic isthmus diameter and flow in pregnant women with intrahepatic cholestasis of pregnancy; may it be a marker of poor perinatal outcomes?

Aim: To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).

Methods: In this prospective case-control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (n: 30) and the control group (n: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.

Sedentary lifestyle induces oxidative stress and atrophy in rat skeletal muscle.

Abundant evidence indicates that skeletal muscle plays a key role in regulating metabolic homeostasis. Therefore, maintaining healthy skeletal muscles is essential to good health. While prolonged muscle inactivity is known to cause oxidative stress and muscle loss, it remains unclear whether a shift from an active to a sedentary lifestyle induces similar effects.

Assessment of salinity trends in a coastal aquifer in Guzelyurt, North Cyprus.

Salinity is a serious concern with groundwater use in irrigation that is very close to a coastal aquifer. The study aims to do a comparative analysis of the physiochemical parameters of groundwater samples obtained from 10 irrigational wells in Guzelyurt. In this study, 10 groundwater samples were collected from irrigational wells in the Guzelyurt aquifer area and were analyzed for important groundwater physiochemical parameters such as pH, EC, Na, Ca, K, Na, Mg, HCO , SO , and Cl.

A New Unc45a 5'utr Variant In Patients With Aagenaes Syndrome.

Aagenaes syndrome, also known as lymphoedema cholestasis syndrome 1 (LCS1), is a rare autosomal recessive disorder characterized by neonatal cholestasis and chronic lymphedema, primarily affecting the lower extremities. The genetic basis for this syndrome was recently linked to a variant in the 5'-untranslated region (5'-UTR) of the UNC45A gene, located on chromosome 15q. This study aimed to identify the genetic mutations associated with Aagenaes syndrome in two siblings and to explore their clinical implications.

Trimethylamine N-Oxide (TMAO) and TNF-α Levels in Periodontal Disease Associated With Smoking.

Aims: Trimethylamine N-oxide (TMAO) is a compound involved in the pathogenesis of various systemic inflammatory diseases, including cardiovascular conditions. The aim of this study was to determine differences in saliva and serum levels of TMAO between periodontitis and healthy patients according to smoking status.

Methods: The study included four systemically healthy groups: periodontally healthy non-smokers (NS-Control; n = 25), non-smokers with Stage-III-Grade-B periodontitis (NS-Periodontitis; n = 25), periodontally healthy smokers (S-Control; n = 25), and smokers with Stage-III Grade-C periodontitis (S-Periodontitis; n = 25).

Computational and experimental mapping of the allosteric network of two manganese ABC transporters.

Transition metals (e.g., Fe, Zn, Mn) are essential enzymatic cofactors in all organisms.

The Effect of European Health Literacy-Based e-Pulse Education and e-Pulse Instructional Materials on Health Literacy Levels in Adults Aged 45-64: A Randomized Controlled Trial.

e-Pulse is an electronic personal health record system known as e-Nabız in Turkey. This study compares the effect of European Health Literacy-based e-Pulse education and e-Pulse instructional materials on the health literacy levels of adults aged 45-64 with inadequate and problematic-limited health literacy levels. This single-blind, randomized controlled trial was conducted from June 2023 to September 2023.

Validity and Reliability Study of the Turkish Adaptation of the "Medical Office Survey on Patient Safety Culture".

Introduction: The safety culture within health care organizations is essential for ensuring patient well-being and optimizing health care delivery. This study addresses the pressing need to establish a culture of patient safety within primary health care settings. The aim is to conduct a comprehensive validity and reliability study for the Turkish adaptation of the "Medical Office Survey on Patient Safety Culture" (MOSPSC) scale, designed to assess patient safety culture in primary care medical offices.

Synergistic anti-cancer effects of piezoelectric hexagonal boron nitride nanocarriers for controlled doxorubicin release.

Aims: This study aims to develop a piezoelectric drug delivery system based on hexagonal boron nitride nanosheets (hBNs).

Materials And Methods: hBNs were synthesized using the chemical vapor deposition (CVD) method and characterized through imaging and spectroscopic techniques. Their piezoelectric properties were evaluated to confirm their functionality.