High satisfaction and low conversion rate to total hip arthroplasty after hip arthroscopy for femoroacetabular impingement syndrome and risk factors affecting survival at long-term follow-up.

Purpose: Studies evaluating the long-term survival rate, patient satisfaction, and conversion to total hip arthroplasty (THA) are limited. The aim of this study was to evaluate satisfaction and hip survival at a minimum 10-year follow-up in patients following hip arthroscopy for femoroacetabular impingement syndrome (FAIS).

Methods: A total of 164 patients underwent hip arthroscopy for FAIS between 2007 and 2012; of these, 76 (49 men and 27 women; mean age, 40.

The relationship between smoking and clinical outcome in ischemic stroke patients undergoing reperfusion therapy.

Background: It has been suggested that smokers have higher recanalization rate, lower risk of cerebral hemorrhage and better prognosis than non-smokers (smoking paradox) after reperfusion therapy in patients with acute ischemic stroke (IS). This study aimed to assess the effects of smoking on recanalization, intracranial hemorrhage, and clinical outcomes in patients with acute IS following reperfusion therapy.

Methods: Patients were categorized into smokers and non-smokers, with data collected on types of reperfusion therapy, demographics, medication use, comorbidities, stroke etiology, mRS and NIHSS scores, TICI and ECASS classifications.

Sport-specific differences in ACL injury, treatment and return to sports: Basketball.

Basketball is an intense, fast-paced game that is physically, highly demanding. Certain aspects of the game, such as the quick pivoting and cutting movements, predispose the players to serious knee injuries, including anterior cruciate ligament (ACL) tears. While an ACL tear can be a devastating condition for players, multidisciplinary management of the injury can provide the players with a reasonable chance to return to play at the pre-injury level.

Thymoquinone and Metabolic Reprogramming in Breast Cancer: A New Dimension From Proteomic Analysis.

Thymoquinone (TQ) has shown antitumorigenic effects in breast cancer; however, its detailed impact on cell signaling mechanisms requires further investigation. This study aims to elucidate the molecular mechanisms behind TQ's antiproliferative effects in breast cancer by analyzing proteome-level changes. MCF-7 cells were treated with 15 µM TQ, the inhibitory concentration (IC50), for 48 h.

Simple Isolation of Human Bone Marrow Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells.

Bone marrow adipose tissue (BMAT) has garnered significant attention due to its critical roles in leukemia pathogenesis, cancer metastasis, and bone marrow failure. BMAT is a metabolically active, distinct tissue that differs from other fat depots. Marrow adipocytes, closely interacting with hematopoietic stem/progenitor cells and osteoblasts, play a pivotal role in regulating their functions.

A rare EGFR exon 19 insertion mutation in metastatic lung adenocarcinoma: a favorable response to afatinib.

Epidermal growth factor receptor (EGFR) mutations like the common L858R and exon 19 deletions are well studied, but rarer mutations like exon 19 insertions have received less attention. This case report describes a patient with this uncommon EGFR exon 19 insertion mutation in metastatic lung adenocarcinoma. A 51-year-old male nonsmoker with metastatic lung adenocarcinoma and a rare EGFR exon 19 insertion mutation experienced disease progression on initial carboplatin-pemetrexed chemotherapy.

Myositis associated with pembrolizumab presenting with myastheniform symptoms: two case reports.

Immune checkpoint inhibitors (ICIs), such as pembrolizumab, have revolutionized cancer treatment by enhancing the immune system's response to malignancies. However, these therapies are associated with immune-related adverse events (irAEs), including neuromuscular complications such as myasthenia gravis, myositis, and myocarditis. We describe two male patients, aged 67 and 68, with small cell and non-small cell lung cancers, who developed progressive neuromuscular symptoms, including ptosis, diplopia, and generalized weakness, after receiving pembrolizumab.

Childbirth Journey Through Virtual Reality: Pain, Anxiety and Birth Perception: A Randomized Controlled Trial.

This study determines video's effect on pregnant women's pain, anxiety, and perception of labor using virtual reality glasses during the active and transition phases of childbirth. This randomized controlled study was conducted with 60 pregnant women (30 in each group) admitted to the delivery room of a hospital. The data were collected by personal information form, visual comparison scale-pain, visual comparison scale-anxiety, and perception of birth scale.

Evaluating two live-attenuated vaccines against serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.

Vaccines that cross-protect across serovars of () would be a beneficial intervention against emerging and persistent isolates of concern for the turkey industry. The 2017-2019 foodborne outbreak of serovar Reading (. Reading) revealed the need for effective control of this serovar in turkey production.

Hajdu-Cheney Syndrome, a Rare Cause of Acro-Osteolysis and Osteoporosis With Zoledronic Acid Experience.

Hajdu-Cheney syndrome (HCS), caused by a heterozygous gain of function variant of the NOTCH2 gene, is a rare skeletal dysplasia. Although the main presentation is acro-osteolysis, osteoporosis, and facial dysmorphism, having a wide range of clinical manifestations creates diagnostic difficulties. Here, a 15-year-old male patient with HCS who had no complaints until this age except for two short bone fractures and one vertebral collapse fracture due to a fall was reported.

Adaptation of the disease-related apathy scale in adults with epilepsy into Turkish: A methodological study.

Objective: This study was conducted to culturally adapt the Epilepsy-Related Apathy Scale in Adults with Epilepsy (E-RAS) to Turkish and to assess its psychometric properties in adult epilepsy patients.

Methods: A total of 172 epilepsy patients receiving care at the Neurology clinic and outpatient clinic of Fırat University Hospital from February to July 2023 were included in this methodological investigation. The E-RAS was translated into Turkish, and its content and construct validity were thoroughly examined.

The Assessment of Post-Earthquake Quality of Life of Earthquake Survivors.

Objectives: This study aims to assess the quality of life (QoL) of earthquake survivors who experienced 2 major earthquakes in Türkiye on February 6, 2023, with different measurement tools.

Methods: The study was conducted in 2 centers with a total of 467 participants. For QoL measurement, face-to-face Euroqol EQ-5D-5L, Euroqol Visual Analog Scale (EQ-VAS), and Nottingham Health Profile (NHP) measurement tools were used.

The Effect of Motivational Interview-Based Education on Nutrition Exercise Behavior, Sedentary Activity Duration, and Anthropometric Outcomes in Obese Adolescents.

Purpose: The aim of this study was to examine the effect of motivational interview-based training on nutrition exercise behavior, sedentary behavior duration, and anthropometric outcomes in adolescents.

Method: This randomized controlled single-blind experimental study was conducted between January 2021 and March 2023. The research sample consisted of 76 adolescents with obesity (intervention: 38 and control: 38) determined by power analysis.

First Report of Causing Root Rot of Incense Cedar in Tennessee and the United States.

Incense cedar [ (Torr.) Florin] is a coniferous evergreen tree, indigenous to western North America, that is being evaluated in Tennessee for its adaptability to eastern U.S.

Postural balance impairment following arthroscopic rotator cuff repair in the early postoperative period: a prospective cohort study.

Background: For patients undergoing arthroscopic rotator cuff repair surgery (RCR), it is crucial to prevent falls to minimize the risk of re-tearing the repaired muscles. Shoulder immobilization during the postoperative period may lead to a decline in postural balance. This prospective cohort study aimed to investigate the postural balance of patients in the early postoperative period following arthroscopic RCR.

What do medical students think about conscientious objection? A cross-sectional study from Turkey.

Background: Physicians' refusal to perform medical procedures that they deem contrary to their conscience may threaten basic human rights and public health. This study aims to investigate the thoughts and attitudes of future physicians on conscientious objection (CO) and thus contribute to the discussions from a country more heavily influenced by Eastern values.

Methods: A cross-sectional multi-center study was conducted among medical students country-wide, where 2,188 medical students participated via an online survey.

Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography.

Background: The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Open Angle Glaucoma (POAG) and Pseudoexfoliation Glaucoma (PXG) eyes.

Methods: 60 POAG and 60 PXG patients and 30 control group patients were included in the study. Patients diagnosed with glaucoma were divided into two groups as mild (Mean deviation (MD) > -6.

Addressing the emerging threat of Oropouche virus: implications and public health responses for healthcare systems.

Oropouche fever is an increasingly significant health concern in tropical and subtropical areas of South and Central America, and is primarily spread by midge vectors. The Oropouche virus (OROV) was first identified in 1955 and has been responsible for numerous outbreaks, particularly in urban environments. Despite its prevalence, the disease is often under-reported, making it difficult to fully understand its impact.

Assessing the short-term hematological and pulmonary effects of air pollution: a cross-sectional study in a Turkish urban setting.

Background: Air pollution has become a significant global public health concern, with evidence linking it to various adverse health outcomes, including respiratory and cardiovascular diseases. While numerous studies have investigated the effects of these particulate and gaseous pollutants on both healthy individuals and patients, further research is needed to clarify the short-term hematological and pulmonary responses in individuals without underlying health conditions. This study aims to explore the relationship between air quality, hematological parameters, and pulmonary function in a healthy population in Turkey.

The relationship between sociodemographic characteristics, lifestyle, and diet quality with diabetes risk in overweight and obese Turkish adults.

Background: Obesity and certain associated environmental factors increase the risk of type 2 diabetes mellitus (T2DM). This research aims to evaluate the relationship between sociodemographic characteristics, lifestyle, and diet quality with diabetes risk in overweight and obese Turkish adults.

Methods: A questionnaire form including sociodemographic characteristics, lifestyle, body weight and height was applied.

Evaluatıon of stress dıstrıbutıon by applıed dıfferent forces on ımmature maxıllary central teeth wıth dıfferent treatment optıons: a laboratory fınıte element stress analysıs.

Background: Immature maxillary central teeth can be managed by using several treatment options. The aim of this finite element stress analysis study was to evaluate the effect of different treatment procedures on the stresses on immature maxillary incisor teeth models that generated on cone beam computed tomography, by trauma and bite forces.

Methods: A total of 11 different models consisting of revascularization treatment using MTA and biodentine and the state of the root apex formed with cement after treatment, apexification, modified apexification, traditional root canal treatment and two different control groups have been created.

Turkish adapration of "Simulation-Based interprofessional Teamwork Assessment Tool": SITAT-TR.

Inroduction: The Simulation-based Interprofessional Teamwork Assessment Tool (SITAT) is a valuable instrument for evaluating individual performance within interprofessional teams.

Aim: This study aimed to translate and validate the SITAT into Turkish (SITAT-TR) to enhance interprofessional education and teamwork assessments in the Turkish context.

Methods: This study was designed as an adaptation study in a descriptive research design.

Evaluation of mandibular and maxillary second molar root canal anatomy in a Turkish subpopulation using CBCT: comparison of Briseno-Marroquin and Vertucci classifications.

Background: This retrospective study aims to characterise the root canal morphology of maxillary and mandibular second molars using cone-beam computed tomography (CBCT). The number of roots and canal configurations were evaluated using both the Vertucci and Benjamı´n Brisen˜ o Marroquı´n classification systems.

Methods: A total of 1084 second molar images (523 maxillary; 266 right and 257 left side and 561 mandibular; 285 right and 276 left side) were evaluated from 320 CBCT scans analyzed for the Turkish subpopulation.

Improved Diagnostic Yield in Recessive Intellectual Disability Utilizing Systematic Whole Exome Sequencing Data Reanalysis.

Recent advances in next generation sequencing (NGS) have positioned whole exome sequencing (WES) as an efficient first-tier method in genetic diagnosis. However, despite the diagnostic yield of 35%-50% in intellectual disability (ID) many patients still remain undiagnosed due to inherent limitations and bioinformatic short-comings. In this study, we reanalyzed WES data from 159 Iranian families showing recessively inherited ID.