Effect of overweight and obesity on live birth rate in single euploid frozen embryo transfers.

Research Question: Does endometrial preparation using a natural cycle lead to higher live birth rates (LBR) in single euploid frozen embryo transfers (FET) compared with programmed cycles, for women who are normal weight, overweight and obese.

Design: Retrospective study of 845 single euploid FETs from 688 couples. Patients were stratified by body mass index (BMI) into normal weight, overweight and obesity class I/II categories.

Ultrafiltration membrane modelling: Comparing two mathematical models by sensitivity and uncertainty analysis for Palermo and Corleone (Italy) water reuse case studies.

The new EU Urban Wastewater Treatment Directive requires stricter limits introducing quaternary treatments and poses significant challenges to achieving a sustainable environment. Advanced membrane-based treatment processes combined with mathematical models can be a good solution for facing the challenges above. Most existing literature on membrane filtration models primarily focuses on membrane bioreactors, lacking mechanistic models on ultrafiltration (UF) membranes.

Chromatographic analysis and pK evaluation of active pharmaceutical ingredients in anti-metastatic breast cancer: Green vs. conventional RPLC.

This study aimed to determine the chromatographic retention and dissociation/protonation constant (pK) values of lapatinib and tamoxifen, key drugs used in metastatic breast cancer treatment, at 37°C using both conventional and green high-performance liquid chromatography (HPLC) methods. Qualitative analysis was conducted on an XTerra C18 column (250 ×4.6 mm I.

Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) presents substantial therapeutic challenges due to its molecular heterogeneity, limited response to conventional therapies, and widespread drug resistance. Recent advancements in molecular research have identified novel targets, such as BUB1B, which has been identified through global transcriptomic profiling and gene co-expression network analysis as critical in ccRCC progression. In this study, we synthesized 40 novel derivatives of TG-101209 to modulate BUB1B expression and activity, leading to the induction of apoptosis in Caki-1 cells.

Environmental controls on the conversion of nutrients to chlorophyll in lakes.

Anthropogenic inputs of nitrogen and phosphorus to lakes have increased worldwide, causing phytoplankton chlorophyll concentrations to increase at many sites, with negative implications for biodiversity and human usage of lake resources. However, the conversion of nutrients to chlorophyll varies among lakes, hindering effective management actions to improve water quality. Here, using a rich global dataset, we explore how the relationship between chlorophyll-a (Chla) and nitrogen and phosphorus and inferred nutrient limitation is modified by climate, catchment, hydrology and lake characteristics.

Two sides of the same coin-sexuality from the perspective of women diagnosed with breast cancer and their partners: A qualitative study.

Purpose: After the diagnosis of breast cancer, women's sexuality becomes complex, and the sexual lives of couples are strongly affected by the treatment process of the disease. The aim of this study is to determine the perceptions, experiences, expectations, and needs related to sexuality from the perspective of women diagnosed with breast cancer and their partners.

Method: In this study, a descriptive qualitative design based on a thematic analysis approach was used.

Prognostic value of systemic immune-inflammation index in older patients with acute coronary syndrome.

Objectives: Contemporary studies assessing the importance of the systemic immune-inflammation index (SII) in older patients presenting with acute coronary syndrome (ACS) are scarce. This study investigated the impact and prognostic value of the SII regarding long-term mortality in older patients with ACS.

Methods: The study included 401 older patients aged 75 years and above admitted with ACS between May 2015 and December 2022.

2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitors.

The inhibition of human microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is a promising therapeutic modality for developing next-generation anti-inflammatory medications. In this study, we present novel 2-phenylbenzothiazole derivatives featuring heteroaryl sulfonamide end-capping substructures as inhibitors of human mPGES-1, with IC values in the range of 0.72-3.

Studying Kurdishness in Turkey: A review of existing research.

Knowledge production on marginalized identities is frequently shaped by epistemic violence, which limits both the scope and methodologies of research. One example of this is the case of Kurdish identity in Turkey, where we find that methodological and epistemic problems are evident particularly in social psychological research. To summarize social psychological studies on Kurdishness, Kurdish identity and conflict in Turkey we've conducted a systematic review that includes a total of 63 studies on topics related to Kurdishness.

Newly defined biomarker for the no reflow phenomenon in patients with non-ST elevation acute coronary syndrome; uric acid to creatinine ratio.

Background: The present study aimed to investigate whether newly defined serum uric acid (SUA) to serum creatinine ratio (SUA/SCr) predicts no-reflow phenomenon (NRP) development in patients with non-ST-elevated acute coronary syndrome (NSTE-ACS).

Methods: The study group was divided into two groups: those who developed NRP and those who did not. Complete blood counts, SUA, serum creatinine, C-reactive protein (CRP) and albumin were obtained at admission.

Traces of Earthquake: Traumatic Life Experiences and Their Effects on Volunteer Nurses in the Earthquake Zone-An Interpretative Phenomenological Study.

Introduction: It is crucial to understand the effects that traumatic events related to natural disasters have on individuals in as much detail as possible. However, the literature investigating the traumatic life experiences of nurses, who play a key role in disaster management, is still limited.

Objective: The aim of this study was to explore in depth the traumatic life experiences of volunteer nurses who participated in relief efforts after two major earthquakes in the southeastern region of Türkiye.

Comprehensive review of animal models in diabetes research using chemical agents.

Diabetes mellitus, characterized by insufficient insulin secretion and impaired insulin efficacy, disrupts carbohydrate, protein, and lipid metabolism. The global diabetic population is expected to double by 2025, from 380 million, posing a significant health challenge. Most diabetic individuals fall into the type 1 or type 2 categories, and diabetes adversely affects various organs, such as the kidneys, liver, nervous system, reproductive system, and eyes.

Theoretical Modeling of the Interactions of CoFeO-BaTiO Magnetoelectric Nanoparticles with Cancer and Healthy Cells.

Introduction: The effectiveness of pharmaceutical treatment methods is vital in cancer treatment. In this context, various targeted drug delivery systems are being developed to minimize or eliminate existing deficiencies and harms. This study aimed to model the interaction of MEN-based drug-targeting systems with cancer cells and determine the properties of interacting MENs.

The civil employment experiences of amputee veterans: The case of Turkey.

Military veterans who became disabled due to conflict-related trauma face various challenges in finding and maintaining employment in civilian life. This study aims to understand the transition processes of disabled veterans in Turkey into civilian employment, as well as their experiences in maintaining and sustaining employment during this process. A qualitative research design was used in the study.

Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia.

Whilst severe liver dysfunction is rarely encountered at the time of diagnosis for patients with acute myeloid leukemia (AML), mild elevations aminotransferase (<5 times the upper limit of normal) may be more frequently seen. Liver dysfunction at the time of diagnosis of AML is a parameter that requires investigation and can assist the clinicians in predicting prognosis. The aim of the present study was to investigate liver dysfunction at the time of diagnosis using the assoicated parameters in patients with AML.

Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity.

Aim: The aim of this study was to compare the effects of dexmedetomidine, midazolam, propofol, and intralipid on lidocaine-induced cardiotoxicity and neurotoxicity.

Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups (n = 8 per group): control (C), lidocaine (L), lidocaine + dexmedetomidine (LD), lidocaine + midazolam (LM), lidocaine + propofol (LP), and lidocaine + intralipid (LI). Dexmedetomidine (100 µg/kg), midazolam (4 mg/kg), propofol (40 mg/kg), and intralipid (10 mg/kg) were administered intraperitoneally as pretreatment.

A new parameter to increase the predictive value of multiparametric prostate magnetic resonance imaging for clinically significant prostate cancer in targeted biopsies: lesion density.

Aim: To investigate the predictive value of lesion length in multiparametric prostate magnetic resonance imaging with respect to prostate volume for clinically significant prostate cancer diagnosis in targeted biopsies.

Materials And Methods: The data of biopsy-naïve patients in the Turkish Urooncology Association Prostate Cancer Database who underwent targeted prostate biopsies were included in this study. Lesion density is calculated as the ratio of lesion length (mm) in MR to prostate volume (cc).

Does the type of the previous biopsy affect the fusion prostate biopsy results?

Background: It has been more than a decade since fusion prostate biopsy (FPB) has been used in the diagnosis of prostate cancer (PCa). Therefore, patients with a previous history of negative FPB and ongoing suspicion of PCa are beginning to emerge. This study investigated whether the first biopsy type (standard or fusion) should be effective in deciding on a second biopsy.

Digital solutions for migrant and refugee health: a framework for analysis and action.

Digital technologies can help support the health of migrants and refugees and facilitate research on their health issues. However, ethical concerns include security and confidentiality of information; informed consent; how to engage migrants in designing, implementing and researching digital tools; inequitable access to mobile devices and the internet; and access to health services for early intervention and follow-up. Digital technical solutions do not necessarily overcome problems that are political, social, or economic.

An examination of immersive journalism by bibliometric analysis from 1999 to 2023.

Immersive journalism is an innovative storytelling approach that aims to enable the audience to experience the event or situation in the news using virtual reality, unlike traditional news narration. In this study, the literature related to the subject was searched using the keywords Immersive Journalism, 360-Degree Video, Narrative journalism, Newsgame, VR Storytelling through the Web of Science database and a data set was created from 955 publications between 1999 and 2023. No filter was applied to the studies in the data set of the study and articles, books, and early access publications as well as book chapters, editorial materials or conference proceedings in the Web of Science database were included in the study.