Modified Push-Through Technique in Bilateral Same-Day Myringoplasty: A Prospective Study.

Objective: This study aims to evaluate the efficacy and safety of the modified push-through technique in bilateral same-day myringoplasty for patients with chronic otitis media. Bilateral myringoplasty, while advantageous in terms of cost and recovery time, is often avoided due to the perceived risks, particularly iatrogenic sensorineural hearing loss (SNHL). This study contributes to the limited literature on simultaneous bilateral ear surgeries by assessing surgical outcomes, including graft success rates and postoperative hearing improvement.

First-Line Tislelizumab Plus Chemotherapy for Advanced Gastric Cancer with Programmed Death-Ligand 1 Expression ≥ 1%: A Retrospective Analysis of RATIONALE-305.

Introduction: Tislelizumab plus investigator-chosen chemotherapy (ICC) demonstrated a statistically significant improvement in overall survival (OS) versus placebo plus ICC in RATIONALE-305 in patients with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric cancer/gastroesophageal junction cancer (GC/GEJC) in the intent-to-treat population and in patients with programmed death-ligand 1 (PD-L1) Tumor Area Positivity (TAP) score ≥ 5%. The United States Food and Drug Administration Oncologic Drugs Advisory Committee voted (September 2024) against first-line treatment with programmed cell death protein-1 inhibitors in this setting in patients with a PD-L1 combined positive score < 1 or TAP score < 1%, due to an unfavorable benefit-risk profile. Thus, we retrospectively analyzed data from RATIONALE-305 in patients with a PD-L1 TAP score ≥ 1%.

Therapeutic Potential of Green Synthesized Polyherbal Formulated Silver Nanoparticles in Alloxan-Induced Diabetes Mellitus-An In Vivo Strategy.

Diabetes mellitus (DM) is a non-communicable, life-threatening syndrome prevalent worldwide. One effective treatment for DM is the medicinal use of green synthesized silver nanoparticles (AgNPs), which are eco-friendly and cost-effective. This study investigates the antidiabetic potential of greensynthesizedAgNPs derived from a polyherbal formulation (PHF).

A project to define standards for radiology staffing, education and training across the European Union.

The European Union Radiation, Education, Staffing & Training (EU-REST) study was a European Commission-funded, 24-month project that analysed workforce availability, education and training needs to ensure quality and safety aspects of medical applications involving ionising radiation in the EU and developed staffing and education/training guidelines for key professional groups involved in ensuring radiation safety and quality of medical radiation applications in the EU Member States. This article outlines the origin, development, goals and overall structure of the project. CRITICAL RELEVANCE STATEMENT: This article provides a concise overview of the EU-REST project, which analysed the workforce availability of health professionals involved in the use of ionising radiation for diagnostic and therapeutic procedures and the corresponding education and training in radiation protection.

Update on the Treatment of Chronic Spontaneous Urticaria.

Chronic spontaneous urticaria (CSU) is a mast cell-mediated skin disease that presents with wheals, angioedema, or both for more than 6 weeks. Less than 10% of patients have complete control of their CSU (the main goal of CSU treatment) with second generation H1-antihistamines, the first-line treatment. About 70% of patients with antihistamine-refractory CSU do not reach complete control with omalizumab, the second-line treatment.

Correlatıon between PET-CT uptake values and pathologıcaly features ın head and neck cancer.

Objectives: To evaluate the correlation between SUV-Max values and pathological outcomes in head and neck squamous cell carcinoma (HNSCC) and determine the predictive power of SUV-Max for disease prognosis.

Data Sources: Retrospective analysis of medical records and PET-CT imaging results from patients diagnosed with HNSCC at our institution between 2014 and 2023.

Review Methods: Examination of SUV-Max values from F18-FDG PET-CT scans and their association with pathological findings such as perineural invasion, lymphovascular invasion, and neck lymph node metastasis.

Planned iliohypogastric neurectomy for prevention of chronic pain after inguinal hernia repair.

Purpose: The present study aimed to investigate the effect of planned ilohypogastric neurectomy (IHPN) in preventing chronic postoperative inguinal pain (CPIP) after anterior herniorrhaphy (AH).

Materials And Methods: This prospective, randomized study was conducted between 2016 and 2023. Emergency and incarcerated hernia cases, bilateral inguinal hernias, cases with complications such as postoperative hematoma infection, cases in which the neuroanatomy of the inguinal region was unintentionally damaged, femoral hernias, and paraplegic patients with loss of sensation who underwent anterior inguinal herniorrhaphy with prolene mesh were excluded, and the remaining 1375 patients were included in this study.

TGFβ links EBV to multisystem inflammatory syndrome in children.

In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion and systemic hyperinflammation. The pathogenesis of MIS-C remains largely unknown.

Effects of reading augmented reality storybook versus normal storybook reading on preoperative fear and anxiety levels of children in the age group of 7-12 years: A randomized controlled trial.

Aim And Objectives: In the preoperative period, non-pharmacological methods such as multimedia applications and visual and audio technological tools are used to reduce children's fear and anxiety levels and to distract their attention to create a more enjoyable experience. One of these innovative technologies having attracted attention recently is augmented reality technology. The study was aimed investigating the effects of reading an augmented reality storybook on fear and anxiety levels of children in the age group of 7-12 years in the preoperative period.

Wear behavior of CAD-CAM zirconia, ceramic, and 3D printed nano-hybrid resin crowns for the restoration of primary and permanent molars: An in vitro study.

Statement Of Problem: Early childhood caries is one the world's most common problems in infants and treatment of posterior teeth with esthetic crowns in a low rate of wear on opposite dentition is a challenge for pediatric dentists.

Purpose: The purpose of this in vitro study was to evaluate the wear behavior of the tooth colored crown materials and the opposing teeth in using different esthetic crown materials in the mixed dentition period.

Material And Methods: The following tooth type and crown materials were considered in the experiment.

Motor Learning-based Clinical Pilates Training for the Parkinson's Disease Rehabilitation @Parkinsonpilates: A Parallel Group, Randomised Controlled Trial with 3-Month Follow-up.

Objectives: To examine the effect of integrated motor learning clinical pilates protocol we developed for patients with Parkinson's Disease (pwPD) on providing enduring motor skills in walking, balance, reaction time, cadence, and functional mobility at 3-months follow-up.

Design: A parallel-group, randomized controlled trial (RCT).

Setting: XXX Medical Center, XXX, and XXX Physiotherapy and Rehabilitation Center, Nicosia.

Can apelins guide the diagnosis of coronary artery disease in COPD patients?

Background: Apelins are adipokines known for their anti-inflammatory, vasodilator, and antiatherosclerotic effects. They are involved in the pathogenesis of chronic diseases like chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD).

Objectives: This study aims to investigate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.

IAEA activities to support the member states in the production of targeted alpha therapy radiopharmaceuticals.

Due to the growing interest of International Atomic Energy Agency (IAEA) Member States in implementing targeted radionuclide therapy (TRT) in general, the demand for alpha-emitting radionuclides and radiopharmaceuticals is enormous. As an international platform for peaceful applications of radionuclides, the IAEA has been implementing several activities focusing on the production and quality control of alpha emitters and radiopharmaceuticals as well as capacity building in the field, through Technical Meetings, Workshops, Publications and Conference Supports, IAEA-Coordinated Research Projects (CRP) and Technical Cooperation Program (TC). This review article summarises the IAEA activities on the production and quality control of alpha emitter radiopharmaceuticals for targeted alpha therapy (TAT) and a roadmap to future steps including but not limited to the ongoing CRP on Ac-radiopharmaceuticals.

In silico identification of multidrug resistance gene (MDR)-targeted transposon miRNAs in human cancer.

miRNAs are small RNA molecules that regulate gene expression and play important roles in various biological processes in cells. The discovery of miRNAs is also of great importance in cancer research. miRNAs enable the development of new approaches in cancer treatment by regulating gene expression in cancer cells and have an important place in cancer development, treatment, and diagnosis.

Anti-cancer effects of boron derivatives on non-small cell lung cancer.

Lung cancer is the most frequently diagnosed cancer globally, with 2.5 million new cases representing 12.4 % of the total number of new cases.

N95 mask usage in children with type 1 diabetes mellitus: Does it affect clinical outcomes?

Background: The global COVID-19 pandemic has necessitated the widespread use of N95 masks, yet their impact on children with chronic conditions like type 1 diabetes (T1DM) remains underexplored.

Objective: This study investigates the effects of N95 mask usage on clinical outcomes in children with T1DM.

Methods: This study enrolled 34 children aged 10-18 with T1DM.

Anticancer potential of Bellardia trixago quantum dots: Cytotoxic effects on various cancer cell lines.

This study investigates the synthesis, characterization, and anticancer effects of carbon quantum dots (CQDs) derived from Bellardia trixago. The CQDs were analyzed using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). TEM results revealed that the CQDs have a spherical morphology and exhibit a layered structure.

FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in .

There is great interest in using genetically tractable organisms such as to gain insights into the regulation and function of sleep. However, sleep phenotyping in has largely relied on simple measures of locomotor inactivity. Here, we present FlyVISTA, a machine learning platform to perform deep phenotyping of sleep in flies.

Antibiotic residues in animal products in Hatay, Turkey.

There are many studies, both abroad and in Turkey, on the detection of antibiotic residues in animal products. However, studies on this subject in the Hatay region are rare. Within the scope of this study, the presence of 14 types of antibiotic residues (ampicillin, amoxycillin, demeclocycline, doxycycline, enrofloxacin, chlortetracycline, novobiocin, oxytetracycline, penicillin G, streptomycin, sulphadimethoxine, sulphamethazine, tetracycline, and tylosin) in samples from animal products such as beef, poultry, milk, and eggs sold unbranded in Hatay were investigated using HPLC.

Individualized Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% Administration in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: The Nurse's Role.

Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% offers potential improvements in patient independence and tolerability versus intravenous immunoglobulin (IVIG) when used for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). fSCIG 10% also requires less frequent infusions and fewer infusion sites than conventional subcutaneous immunoglobulin (subcutaneous immunoglobulin without hyaluronidase). The ADVANCE-CIDP 1 study demonstrated fSCIG 10% efficacy and safety in preventing CIDP relapse and positive responses from patients in terms of satisfaction and treatment preference.

Effects of HLA-DRA, HLA-DQA1 and IL-6 Gene Variations to Glatiramer Acetate Resistance in Multiple Sclerosis Patients.

Multiple sclerosis (MS) is among the most common autoimmune disorders and is characterized by inflammation and degeneration affecting the central nervous system. Glatiramer acetate (GA) is an immunomodulatory drug utilized for treating relapsing-remitting MS. However, a considerable number of patients do not exhibit an appropriate response to this drug.

Evaluation of the effects of bisphosphonate therapy on the temporomandibular joint using cone beam computed tomography.

Objective: The aim of this study was to evaluate the mandibular condyle and articular eminences of patients diagnosed with medication-related osteonecrosis of the jawbone (MRONJ) and those who use bisphosphonates (BP) but do not have MRONJ findings, by comparing them with a healthy control group.

Methods: The cone beam computed tomography (CBCT) images of 20 patients (15 male, 5 female) who were diagnosed with MRONJ and 20 patients (16 male and 4 female) who were using bisphosphonates but had no MRONJ were included in the study. A control group consisted of 20 age- and gender-matched patients (13 male, 7 female) who had no clinical complaints or signs and symptoms of TMD or rheumatic disease.

Atrial and ventricular strain changes after transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: a feature tracking cardiac MRI study.

Purpose: In patients with repaired tetralogy of Fallot, transcatheter or surgical pulmonary valve replacement is recommended. However, it is not clear whether pulmonary valve replacement preserves systolic and diastolic functions of both ventricles. The aim of the study is to investigate the impact of transcatheter pulmonary valve replacement on atrial and ventricular myocardial strain changes by feature-tracking cardiac magnetic resonance imaging.