Persistent Prostate-Specific Antigen Following Radical Prostatectomy for Prostate Cancer and Mortality Risk.

Importance: Whether the conventional 1.5-month to 2.0-month time interval following radical prostatectomy (RP) for prostate cancer (PC) is sufficient to accurately document a persistent prostate-specific antigen (PSA) remains unanswered.

Unraveling the Complexities of Sleep Disturbances: A Scientific Perspective.

Uzunçıbuk H, Fiorillo L, Ronsivalle V, . Unraveling the Complexities of Sleep Disturbances: A Scientific Perspective. J Contemp Dent Pract 2024;25(12):1081-1083.

External Validation and Comparison of Current Scoring Systems in Encrusted Ure-teral Stent Management: a Multicenter Study.

Purpose: To compare the external validation of four existing scoring systems for encrusted ureteral stents (EUS) and their relationship with stent indwelling time, stone-free rates, multiple surgery sessions, multimodal procedures, and prolonged operation times exceeding 120 minutes in total.

Materials And Methods: The data of 208 patients who underwent surgery for EUS reviewed. All EUSs were evaluated with 4 scoring systems: ESB (encrusted stone burden), FECal (forgotten, encrusted, calcified), KUB (kidney, ureter and bladder), V-GUES (visual grading for ureteral stone burden).

Arterio-veno-lymphatic vascular malformation presenting as an anterior mediastinal mass.

Mediastinal lymphatic venous malformation (LVM) is considered tumor-like vascular dysplasias that are rarely found in the mediastinum. Clinical presentation of LVMs varies depending on the patient. Patients may be asymptomatic or may present with symptoms such as cough, chest pain, dyspnea, and hemoptysis.

The systemic immune-inflammation index is an independent predictive factor in predicting major amputation in chronic limb-threatening ischemia.

BackgroundLower extremity peripheral arterial disease (LEAD) is characterized by the narrowing and occlusion of arteries in the lower extremities. The most severe form of LEAD is chronic limb-threatening ischemia (CLTI), which carries a poorer prognosis for major amputation. The systemic immune-inflammation index (SII) is an index developed to simultaneously reflect the inflammatory and immunothrombosis status of patients, based on platelet counts and the neutrophil-to-lymphocyte ratio.

Extracellular matrix dynamics in a rat model of pulmonary arterial hypertension: unveiling the role of hyaluronan in disease pathology.

Objective: We aimed to investigate the feasibility of conducting extracellular matrix studies within this rat model.

Materials And Methods: This study involved 24 Sprague Dawley rats, divided into two groups. Group 1 served as the normoxia control, while Group 2 is SU-5416 pulmonary arterial hypertension (PAH) model.

Validity and reliability of the 6-min stepper test in hypertensive individuals.

Background: Hypertension is a common public health problem characterized by high blood pressure (BP) and associated with complications such as coronary artery disease, stroke, and renal failure. Physical activity and exercise regulate BP, and assessment of exercise capacity is a cornerstone of exercise training.

Objective: The aims of this study were to evaluate the validity and reliability of the 6-min stepper test (6MST) in hypertensive individuals and compare their physiological responses during the 6MST and 6-min walk test (6MWT).

Dual-Functioning Metal-Organic Frameworks: Methotrexate-Loaded Gadolinium MOFs as Drug Carriers and Radiosensitizers.

Cancer remains a critical global health challenge, necessitating advanced drug delivery systems through innovations in materials science and nanotechnology. This study evaluates Gadolinium Metal-Organic Frameworks (Gd-MOFs) as potential drug delivery systems for anticancer therapy, particularly when combined with radiotherapy. Gd-MOFs were synthesized using terephthalic acid and gadolinium (III) chloride hexahydrate, then loaded with methotrexate (MTX).

A case of diplopia masquerading as ptosis: Unveiling a hidden clival chordoma.

IntroductionChordomas are malignant tumours derived from residual notochord tissue. They are characterized by slow growth and local aggressiveness. Visual symptoms commonly arise from the compression of neighbouring structures.

Clinical Characteristics of Cognitive Subgroups of Obsessive Compulsive Disorder.

Introduction: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder. The results of symptom-based classification studies are inconsistent in resolving this heterogeneity. The aim of this study was to investigate clinical differences between clusters created according to neurocognitive performance.

Emergence of plasmid-mediated fosfomycin resistance among harboring , (X4), and genes in wild birds.

Unlabelled: Fosfomycin represents a last-line reserve antibiotic for the treatment of infections caused by multidrug-resistant (MDR) bacteria. Nevertheless, the advent of plasmid-mediated fosfomycin resistance among bacteria from humans and food animals incurs great concern. This study reports the detection and genomic portrait of the plasmid-mediated fosfomycin resistance gene, , amid from wild birds co-harboring plasmid-mediated tigecycline resistance gene(X4), and colistin resistance gene, .

Radiologic and Clinical Anatomy of the Zygomatic Bone in Terms of Zygomatic Implant.

The zygomatic bone is crucial in dental implantology, wherein zygomatic implants are increasingly used for patients with insufficient maxillary bone. A comprehensive understanding of the complex anatomy of the zygomatic bone is essential for minimizing surgical complications and optimizing implant success. This study aimed to provide morphometric data through cone-beam computed tomography (CBCT) and microcomputed tomography (μCT) to assist dental radiologists and surgeons in preoperative planning and implant placement.

Evaluation of Risk Factors in Patients With Chronic Daily Headache and Medication-Overuse Headache.

Purpose: The aim of this study is to compare the quality of life, daily physical activity level and perception of illness in patients with chronic daily headache, medication-overuse headache, episodic migraine, and episodic tension-type headache across disease subgroups with respect to possible risk factors such as alcohol/caffeine/nicotine use, eating attitude, which may trigger chronic headache and medication overuse.

Materials And Methods: VAS, International Physical Activity Questionnaire (Short) forms, SF-36 Quality of Life Scale, Illness Perception Questionnaire, Beck Anxiety Inventory, Beck Depression Inventory, Eating Disorder Examination Questionnaire, Eating Attitude Test, SCID-I were applied to the patients.

Results: Disease type mean score and psychological causes mean score were found to be the highest in the chronic tension type headache (CTTH) group among tension type headache (TTH) subgroups.

Challenge in a Malrotation Case: Presentation Mimicking Severe Combined Immunodeficiency.

Objectives: Malrotation is a congenital anomaly characterized by improper positioning of the intestines that can cause a range of symptoms from asymptomatic to life-threatening, including midgut volvulus. Diagnosis of malrotation can be particularly challenging in cases where symptoms resemble those of other illnesses, such as severe combined immunodeficiency (SCID).

Case Report: In this case study, we describe a 2-month-old girl with midgut volvulus secondary to malrotation.

Radiological risk assessment due to radon in bottled drinking water sold in Kahramanmaraş town, Turkiye.

This research aimed to measure radon activity concentrations in bottled drinking water (BDW) samples consumed in Kahramanmaraş town, Turkiye. Also, to evaluate the health risk that may occur as a result of internal irradiation resulting from ingestion and inhalation of radon in BDW samples, the total annual effective dose equivalent (AEDE) for infants, children, and adults (1-2 y, 2-12 y, and > 17 y) and excess lifetime cancer risk (ELCR) for adults (> 17 y) had to be calculated. For these purposes, 32 water samples of different volumes belonging to 8 different commercial brands, representing a large part of the BDW consumed as drinking water and sold commercially in Kahramanmaraş were collected by purchasing from markets.

Anagen Effluvium in a Child Misusing Methotrexate: A Case Report With Dermoscopic Findings.

Anagen effluvium is a rare adverse effect of methotrexate therapy, generally associated with high-dose regimens. We report a 12-year-old girl who developed abrupt hair loss 1 week after inadvertently taking methotrexate 15 mg daily for five consecutive days (total 75 mg), without other signs of systemic toxicity. Trichoscopic examination and trichogram findings confirmed methotrexate-induced anagen effluvium, and spontaneous hair regrowth occurred after 2 months.

Evaluation of functional and aesthetic outcomes following open technique septorhinoplasty: assessing the utility and correlation of the Rhinoplasty Health Inventory and Nasal Outcomes, Rhinoplasty Outcome Evaluation, and Nasal Obstructive Symptom Evaluation questionnaires.

Background: The importance of subjective quality of life questionnaires in evaluating post-rhinoplasty outcomes and patient satisfaction is increasing.

Objective: This study aimed to measure the aesthetic and functional satisfaction of patients following septorhinoplasty using the Rhinoplasty Health Inventory and Nasal Outcomes (RHINO), Rhinoplasty Outcome Evaluation (ROE), and Nasal Obstructive Symptom Evaluation (NOSE) questionnaires.

Methods: This prospective study included 306 patients who underwent a primary open-technique septorhinoplasty.

Assessment of unrecognized myocardial infarction using cardiac magnetic resonance imaging in patients with endstage renal disease.

Objective: To assess the frequency of unrecognized myocardial infarction and identify additional ischemic conditions, as well as to evaluate the efficacy of cardiac magnetic resonance imaging (CMRI) in risk groups, comparing the imaging findings with electro-cardiographic (ECG) and laboratory data in patients with stage 5 chronic kidney disease, also known as end-stage renal disease.

Materials And Methods: This was a prospective single-center study involving 20 patients who were referred to our radiology department to undergo CMRI between June 2010 and December 2011. Resting left ventricular functions and (early and late) myocardial contrast enhancement were assessed in all patients.

Understanding key factors contributing to mental health challenges among pediatric nurses: a systematic review.

Background: The mental health and wellbeing of nurses, particularly pediatric nurses, have garnered attention due to the increased risk of mental health challenges associated with their demanding profession. These nurses are especially vulnerable, yet their mental wellbeing is often understudied.

Objective: This systematic review aims to identify and analyze key factors associated with mental health challenges among pediatric nurses and explore how these factors interact to influence their wellbeing.

Artificial intelligence (ChatGPT) ready to evaluate ECG in real life? Not yet!

Objective: This study aims at evaluating if ChatGPT-based artificial intelligence (AI) models are effective in interpreting electrocardiograms (ECGs) and determine their accuracy as compared to those of cardiologists. The purpose is therefore to explore if ChatGPT can be employed for clinical setting, particularly where there are no available cardiologists.

Methods: A total of 107 ECG cases classified according to difficulty (simple, intermediate, complex) were analyzed using three AI models (GPT-ECGReader, GPT-ECGAnalyzer, GPT-ECGInterpreter) and compared with the performance of two cardiologists.

Early outcomes of left bundle branch area pacing in children.

Objective: Left bundle branch area pacing is a recent technique gaining rapid acceptance due to its broader target area and excellent electrical parameters. The aim of this study was to demonstrate the feasibility of left bundle branch area pacing in children and share short-term results.

Materials And Methods: A retrospective study conducted at a single centre between December 2021 and April 2024 involved 19 children who underwent left bundle branch area pacing using Select Secure leads.

Tunneled Catheter-Related Bloodstream Infections in Chronic Hemodialysis Patients: Frequency, Risk Factors, and Outcomes-A 10-Year Analysis.

The aim of this study is to investigate the rate, risk factors, causative microorganism distribution, and treatment outcomes of catheter-related bloodstream infection (CRBSI) in chronic hemodialysis patients undergoing treatment with a tunneled hemodialysis catheter. Data for all patients who underwent hemodialysis treatment with tunneled catheters at our center between January 2014 and January 2024 were retrospectively analyzed. A total of 171 patients were included in the study.

Assessing the prognostic value of HALP score in peripheral artery disease: Correlation with lesion severity and long-term mortality.

IntroductionPeripheral artery disease (PAD) poses a growing clinical challenge due to an aging population, despite advances in treatment methods. Various scoring systems have emerged to predict high-risk patients, including the HALP (hemoglobin, albumin, lymphocyte, and platelet) score, known for predicting prognosis in cancers and stroke. This study assesses the HALP score's relation to lesion severity and long-term mortality in PAD patients.

Effects of Medium Cut-Off Dialyzers on Fat Tissue and Muscle Mass Indices.

Background: Medium cut-off (MCO) dialyzers are designed to provide clearance of large-middle molecular weight uremic toxins and cytokines that are also responsible for the pathogenesis of sarcopenia.

Aim: To investigate the short- and long-term effects of MCO dialyzers on fat and muscle mass.

Methods: This single-center prospective, cross-over study includes 20 maintenance hemodialysis (MHD) patients treated with low-flux (LF) dialyzers.

Can urticaria severity be used as a biomarker for transition from acute to chronic urticaria?

Background: Acute urticaria usually resolves spontaneously; however, in some cases, it may progress to CSU. We aimed to investigate the underlying factors of AU in children and the clinical and laboratory factors affecting the progression of AU to CSU.

Methods: A prospective analysis was performed in 155 patients under 18 years of age who were diagnosed with AU and treated in our hospital.