Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer.

The enzyme phosphatidylinositide-3-kinase (PI3K) regulates cellular proliferation and apoptosis. Somatic mutations in the PIK3CA gene can accelerate these processes and significantly contribute to the development and progression of breast cancer. This study aimed to ascertain the PIK3CA gene mutations in breast cancer patients and investigate their correlation with certain clinicopathological characteristics.

Comparative performance of artificial neural networks and support vector Machines in detecting adulteration of apple juice concentrate using spectroscopy and time domain NMR.

The detection of adulteration in apple juice concentrate is critical for ensuring product authenticity and consumer safety. This study evaluates the effectiveness of artificial neural networks (ANN) and support vector machines (SVM) in analyzing spectroscopic data to detect adulteration in apple juice concentrate. Four techniques-UV-visible, fluorescence, near-infrared (NIR) spectroscopy, and time domain H nuclear magnetic resonance relaxometry (H NMR)-were used to generate data from both authentic and adulterated apple juice samples.

Serum Neudesin Levels in Patients with Congenital Hypothyroidism.

Objectives: Neudesin is a newly discovered protein mainly secreted from adipose tissue and the brain. It plays a role as a neurotrophic factor in the brain and a negative regulator of energy expenditure. Neurodevelopmental delay and cognitive dysfunction are common features in cases with congenital hypothyroidism (CH) without treatment.

Current Practices in Hashimoto's Thyroiditis: Differences in Attitudes Between Pediatric and Adult Endocrinologists in Türkiye: A National Survey.

Introduction: This study aimed to assess the clinical practices and attitudes towards Hashimoto's thyroiditis (HT) among pediatric (PEs) and adult endocrinologists (AEs).

Methods: The members of Turkish Society for Pediatric Endocrinology and Diabetes (n=502) and the Society of Endocrinology and Metabolism of Türkiye (n=910) were invited to participate in an online survey.

Results: Of the respondents (n=168), 72.

Healing beyond bone: a qualitative study of the core decompression experience of physically active patients with stage II hip avascular necrosis.

Background: Avascular necrosis (AVN) of the femoral head is a degenerative condition characterized by ischemic bone death, resulting in pain and impaired mobility. Core decompression, a surgical intervention, is widely performed for stage II AVN to alleviate symptoms and delay disease progression. While clinical and radiological outcomes are well-documented, the psychosocial dimensions of recovery remain underexplored.

Could serum Raftlin and GPER-1levels be new biomarkers for early detection of non-small cell lung cancer?

Background: Lung cancer is the leading cause of cancer-related deaths worldwide. Therefore, the search for new biomarkers continues in order to diagnose lung cancer at an early stage. In this study, we investigated blood levels of G-protein associated membrane estrogen receptor (GPER)-1 and Raftlin as markers of early-stage in lung cancer.

Effect of modeling liquid application on color stability and surface roughness of single-shade composites.

Objectives: The objective of this study was to examine the effects of modeling liquid application on the color stability and surface roughness of single-shade composites.

Materials And Methods: Single-shade composites were divided into 4 main groups according to their contents. A total of 64 disc-shaped samples (8 × 2 mm) were prepared, 16 in each group, by using Teflon molds.

Parental and individual determinants of dental trust in children: a path analysis of a conceptual model.

Background: Understanding the interactions among predictors of dental trust in children is important for designing effective interventions in pediatric dental care.

Aim: This study aimed to develop and validate a conceptual model to evaluate factors influencing dental trust in children.

Design: This cross-sectional study included 267 parent-child dyads.

Patterns among factors associated with myocardial infarction: chi-squared automatic interaction detection tree and binary logit model.

Background: Although mortality from myocardial infarction (MI) has declined worldwide due to advancements in emergency medical care and evidence-based pharmacological treatments, MI remains a significant contributor to global cardiovascular morbidity. This study aims to examine the risk factors associated with individuals who have experienced an MI in Türkiye.

Methods: Microdata obtained from the Türkiye Health Survey conducted by Turkish Statistical Institute in 2019 were used in this study.

Incidence and outcomes of dysnatremia in crush injury patients admitted to Türkiye's largest hospital following the Kahramanmaraş earthquake.

Objectives: Dysnatremia is a critical electrolyte disturbance that can significantly impact the prognosis of trauma patients by influencing fluid balance, neurological function, and hemodynamics. Although sodium disorder is common in hospitalized patients, few studies have specifically examined the incidence of dysnatremia in patients presenting to the emergency department for post-earthquake trauma. The aim of this study is to evaluate the incidence of dysnatremia and the prognosis of patients with dysnatremia in trauma patients admitted to our center after the Kahramanmaraş earthquake.

Integrating Retinal Segmentation Metrics with Machine Learning for Predictions from Mouse SD-OCT Scans.

Purpose: This study aimed to initially test whether machine learning approaches could categorically predict two simple biological features, mouse age and mouse species, using the retinal segmentation metrics.

Methods: The retinal layer thickness data obtained from C57BL/6 and DBA/2J mice were processed for machine learning after segmenting mouse retinal SD-OCT scans. Twenty-two models were trained to predict the mouse groups.

ML-based tooth shade assessment to prevent metamerism in different clinic lights.

The aesthetic understanding has found its place in dental clinics and prosthetic dental treatment. Determining the appropriate prosthetic tooth color between the clinician, patient and technician is a difficult process due to metamerism. Metamerism, known as the different perception of the color of an object under different light sources, is caused by the lighting differences between the laboratory and the dental clinic.

Caustic recovery from caustic-containing polyethylene terephthalate (PET) washing wastewater generated during the recycling of plastic bottles.

To prevent water scarcity, wastewater must be discharged to the surface or groundwater after being treated. Another method is to reuse wastewater in some areas after treatment and evaluate it as much as possible. In this study, it is aimed to recover and reuse the caustic (sodium hydroxide, NaOH) used in the recycling of plastic bottles from polyethylene terephthalate (PET) washing wastewater.

Development of a fixed-order [Formula: see text] controller for a robust P&O-MPPT strategy to control poly-crystalline solar PV energy systems.

This paper presents a novel approach to modeling and controlling a solar photovoltaic conversion system(SPCS) that operates under real-time weather conditions. The primary contribution is the introduction of an uncertain model, which has not been published before, simulating the SPCS's actual functioning. The proposed robust control strategy involves two stages: first, modifying the standard Perturb and Observe (P&O) algorithm to generate an optimal reference voltage using real-time measurements of temperature, solar irradiance, and wind speed.

Nephrectomy in Autosomal Dominant Polycystic Kidney Disease: A consensus statement of the ERA Genes & Kidney Working Group.

A substantial number of patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) undergo a nephrectomy, especially in work-up for a kidney transplantation. Currently, there is no evidence-based algorithm to guide clinicians which patients should undergo nephrectomy, the optimal timing of this procedure, or the preferred surgical technique. This systematic review-based consensus statement aimed to answer important questions regarding nephrectomy in ADPKD.

Fronto-orbital advancement: Comparison of syndromic and nonsyndromic craniosynostosis patients.

Craniosynostosis causes functional and aesthetic problems that require fronto-orbital advancement in patients to correct the cranial deformity and to prevent functional problems due to increased intracranial pressure (ICP). In this study, demographic information, operative details, preoperative clinical findings, and postoperative outcomes were reviewed for 106 craniosynostosis patients with at least 1 year of follow-up. Many factors such as functional losses due to increased ICP before surgery, resynostosis, fronto-orbital relapse, surgical complications and aesthetic results were compared in syndromic and non-syndromic patients.

Perioperative Variation of Plasma Copeptin and Its Association With Vasopressor Need During Liver Transplantation.

Background: Vasopressor usage during liver transplant is related to decreased hepatic flow, graft failure, and mortality. We measured plasma Copeptin levels in liver transplant patients based on vasopressor requirements. We hypothesize that preoperative plasma copeptin measurement helps predict the vasopressor infusion requirement during liver transplantation in preoperative evaluation.

Analysis of the Auditory-Perceptual Voice Quality in Older and Younger Adults Without Self-Reported Voice Complaints.

Objectives: The objectives of this study were to compare the auditory perceptual voice quality in young and older adults who had no self-reported voice complaints and to investigate the relationship of voice quality with age and gender in older adults.

Study Design: This is a retrospective study.

Materials And Methods: This study included 114 participants.

Comparison of the Predictive Role of Spiritual Well-Being and Pain Intensity on Pain Catastrophizing in Acute and Chronic Pain.

Aim: This study was conducted to compare the predictive effect of spiritual well-being and pain intensity on pain catastrophizing of individuals with acute and chronic pain.

Design: This research is a cross-sectional and comparative study.

Methods: The study included 116 individuals with chronic pain and 111 individuals with acute pain.

Risk of bias assessment tools often addressed items not related to risk of bias and used numerical scores.

Objective: We aimed to determine whether the existing risk of bias assessment tools addressed constructs other than risk of bias or internal validity, and whether they used numerical scores to express quality, which is discouraged and may be a misleading approach.

Methods: We searched Ovid MEDLINE and Embase to identify quality appraisal tools across all disciplines in human health research. Tools designed specifically to evaluate reporting quality were excluded.