Therapeutic Potential of Rosmarinic Acid in Tramadol-Induced Hepatorenal Toxicity: Modulation of Oxidative Stress, Inflammation, RAGE/NLRP3, ER Stress, Apoptosis, and Tissue Functions Parameters.

Aim: Tramadol (TRM), a widely used opioid analgesic for moderate to severe pain, is associated with liver and kidney toxicity at high doses or prolonged use. This study investigates the protective role of rosmarinic acid (RA), a natural phenolic compound known for its antioxidant, anti-inflammatory, and cell-protective properties, against TRM-induced hepatorenal toxicity.

Methods: Thirty-five male Wistar rats were divided into five groups: Control, TRM, RA, TRM+RA25, and TRM+RA50.

Challenges encountered by emergency nurses in forensic case management: A qualitative study.

Purpose/aims: This study aimed to reveal the opinions of emergency room nurses regarding crime victims and the challenges they experience.

Design: This study was a qualitative descriptive study.

Methods: A convenience sampling method was used in the study.

A cultural adaptation study of nursing informatics competency scale.

Objective: The objective of this study is to examine the factor structure, internal consistency reliability and responsiveness of an instrument related to the informatics competency of nurses.

Background: Informatics is a scientific discipline that needs to be integrated into nursing practice. There is no current and valid tool to measure the informatics competency of nurses in Turkey.

Placental mesenchymal dysplasia in a monochorionic-diamniotic twin pregnancy complicated with hydrops fetalis-with a review of literature.

Placental mesenchymal dysplasia (PMD) is a rare placental pathology that sonographically mimics gestational trophoblastic diseases. However, mesenchymal dysplasia can be distinguished from other conditions by the presence of villous edema and the absence of trophoblastic proliferation in the placental tissue. This pathology has been demonstrated to be associated with fetal growth restriction, Beckwith-Wiedemann syndrome, some chromosomal abnormalities and intrauterine fetal demise.

Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation.

The research sought to assess the therapeutic impact of resveratrol by biochemical, immunohistochemical, and histopathological analyses in a TiO-induced liver fibrosis model. Titanium dioxide (100 mg/kg body weight) was delivered for 15 days to induce liver fibrosis, either alone or in conjunction with resveratrol (30 mg/kg body weight) therapy for the same duration. Resveratrol has been identified as a crucial therapeutic drug that provides an alternative treatment method for TiO-induced liver fibrosis by mitigating inflammation, oxidative stress, and the expressions of α-SMA and 8-OHdG.

Prognostic nutritional index as a predictor of mortality in acute ischemic stroke.

Objective: Nutritional and immune status have been recognized as important factors influencing the prognosis of acute ischemic stroke. This study aims to evaluate the prognostic value of the Prognostic Nutritional Index (PNI) in predicting 30-day mortality in patients with acute ischemic stroke.

Methods: A retrospective cohort study was conducted in a tertiary care hospital emergency department.

A Perspective on Women's Health With Cupping Therapy: A Review.

Cupping therapy is an ancient traditional and complementary treatment practice. Cupping therapy has recently attracted global attention in the promotion, protection, and treatment of health. Research is also being conducted on the potential benefits of cupping therapy in the treatment of conditions related to women's health.

Retraction Note: A MobileNet-based CNN model with a novel fine-tuning mechanism for COVID-19 infection detection.

[This retracts the article DOI: 10.1007/s00500-022-07798-y.].

Retraction Note: SCLAVOEM: hyper parameter optimization approach to predictive modelling of COVID-19 infodemic tweets using smote and classifier vote ensemble: Taiwo Olaleye.

[This retracts the article DOI: 10.1007/s00500-022-06940-0.].

Retraction Note: Distance education tool selection using novel spherical fuzzy AHP EDAS.

[This retracts the article DOI: 10.1007/s00500-022-06763-z.].

A study on the determination of the factors affecting the happiness levels of older individuals during the COVID-19 pandemic in Turkish society.

This study aims to determine the factors affecting the happiness levels of older individuals in Türkiye during the COVID-19 pandemic. The microdata set from the 2020 Life Satisfaction Survey conducted by the Turkish Statistical Institute was utilized, involving 1,863 individuals aged 60 and above. The relationship between happiness levels and various factors was investigated using the chi-square independence test, and the factors affecting happiness were further analyzed through generalized ordered logistic regression.

Dynamine 3 as a Diagnostic and Prognostic Biomarker in Pancreatic Cancer: Implications for Early Detection and Targeted Therapy.

Background: Dynamins are defined as a group of molecules with GTPase activity that play a role in the formation of endocytic vesicles and Golgi apparatus. Among them, DNM3 has gained recognition in oncology for its tumor suppressor role. Based on this, the aim of this study is to investigate the effects of the DNM3 gene in patients diagnosed with pancreatic cancer using bioinformatics databases.

Microplastic accumulation in various bird species in Turkey.

Plastic pollution constitutes one of the major environmental problems of our time, and in recent years, it has emerged as a significant threat to the environment and to various organisms, including bird species. In this context, this study, which provides the first data in Türkiye, aimed to determine the level of microplastic (MP) pollution in 12 bird species (Eurasian buzzard; short-toed snake-eagle; white stork; northern long-eared owl; common barn-owl; ruddy shelduck; Eurasian eagle-owl; scarlet macaw; common pheasant; Indian peafowl; common kestrel; and gray parrot). The results indicate that MPs were detected in 50% of the specimens (n = 20), with an average of one MP/item per individual.

Pathway from Earthquake Fear to Post-Traumatic Growth: The Roles of Resilience, Self-Efficacy, and Positive Childhood Memories Among Survivors of the 2023 Türkiye Earthquakes.

Posttraumatic growth is essential for understanding how individuals process trauma and adapt psychologically in the aftermath of seismic events. This study aims to explore the mediating effects of resilience, self-efficacy, and positive childhood memories on the relationship between fear of earthquakes and post-traumatic growth among survivors of the 2023 Türkiye earthquake (N = 423). The results of a multi-mediation analysis indicated that earthquake fear indirectly influenced post-traumatic growth through resilience, self-efficacy, and positive childhood memories.

Deep Learning Enabled Scoring of Pancreatic Neuroendocrine Tumors Based on Cancer Infiltration Patterns.

Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms that include tumors with different histomorphologic characteristics that can be correlated to sub-categories with different prognoses. In addition to the WHO grading scheme based on tumor proliferative activity, a new parameter based on the scoring of infiltration patterns at the interface of tumor and non-neoplastic parenchyma (tumor-NNP interface) has recently been proposed for PanNET categorization. Despite the known correlations, these categorizations can still be problematic due to the need for human judgment, which may involve intra- and inter-observer variability.

Optical coherence tomography and fundus autofluorescence features in choroidal and retinal tumors.

The aim of the study was todescribe the clinical features, optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging in patients with choroidal and retinal tumors. Ninety eyes of 89 patients with treatment-naive macular, midperipheral, and juxtapapillary choroidal and retinal tumors were retrospectively included in the study. All patients underwent a complete ophthalmic examination, B-mode ultrasonography, OCT, and FAF imaging.

A complete response with daratumumab, venetoclax, azacitidine and dexamethasone in a heavily pre-treated, chemo-refractory early T-precursor acute lymphoblastic leukemia/lymphoma patient.

Early T-precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) is a rare and aggressive subtype of T-cell leukemia with poor prognosis and resistance to standard treatments. We report a 21-year-old male with ETP-ALL/LBL who, after an initial complete remission with the HOELZER protocol, experienced early relapse and was refractory to subsequent FLEND and BFM protocols. Following disease progression and complications, he was treated with a combination of daratumumab, venetoclax, azacitidine, and dexamethasone.

Survey of legislative frameworks and national recommendations governing paediatric maintenance haemodialysis in Europe.

Background: The application of international recommendations for paediatric maintenance haemodialysis (HD) could be strengthened by national laws or written recommendations. Our aim was therefore to describe the national rules governing paediatric maintenance HD in European countries.

Methods: A national representative, approved by the president of each paediatric nephrology society, was contacted in all 42 European countries to complete two online questionnaires.

Determination of women's perception of traumatic birth and influencing factors.

This study was conducted with a total of 273 women who had at least one vaginal birth in order to examine women's perceptions of traumatic births and the factors affecting these perceptions. This is a descriptive and correlational study. Womens Traumatic Birth Perception Scale (TBPS) mean score was 59.

The Effect of Early Mobilization on Pain and Mobility Levels in Patients Undergoing Total Knee Prosthesis.

Purpose: This study was conducted to determine the effect of early mobilization on pain and mobility levels in individuals undergoing total knee arthroplasty.

Design: Randomized controlled clinical trial.

Methods: This study was carried out in the orthopedic and traumatology department of a public hospital in Turkey.

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

Background And Objectives: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as "intermittent" or "persistent" and "mild" or "moderate-severe". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.

Methods: We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months.