Immunohistochemical markers of potential utility in identifying POLE-mutant endometrial carcinomas: An assessment of autocrine motility factor (AMF) and autocrine motility factor receptor (AMFR).

POLE status determination is necessary for the molecular classification of endometrial carcinomas (EC). However, this determination is only achievable by molecular techniques, which are not available in many practice settings. A previously published study reported elevated AMF/GPI and AMFR/gp78 levels in POLE-mutant EC.

Preoperative estimation of hamstring autograft graft diameter in anterior cruciate ligament reconstruction with a new simple method using magnetic resonance imaging.

Background: The aim of this study was to predict intraoperative graft diameter with our new method by evaluating the cross-sectional areas (CSAs) of the hamstrings in axial sections of MRI.

Methods: This study included 78 patients who underwent single-bundle ACLR between 2022 and 2023. MRIs of the patients were evaulated preoperatively and four CSAs of the hamstring tendons were measured in two different regions by two participants.

Current trends in the design and fabrication of PRP-based scaffolds for tissue engineering and regenerative medicine.

Blood-derived biomaterials with high platelet content have recently emerged as attractive products for tissue engineering and regenerative medicine (TERM). Platelet-derived bioactive molecules have been shown to play a role in wound healing and tissue regeneration processes by promoting collagen synthesis, angiogenesis, cell proliferation, migration, and differentiation. Given their regenerative potential, platelet-rich blood derivatives have become a promising treatment option for use in a variety of conditions.

Investigating the role of large language models on questions about refractive surgery.

Background: Large language models (LLMs) are becoming increasingly popular and are playing an important role in providing accurate clinical information to both patients and physicians. This study aimed to investigate the effectiveness of ChatGPT-4.0, Google Gemini, and Microsoft Copilot LLMs for responding to patient questions regarding refractive surgery.

The correlation histopathological and conventional/advanced MRI techniques in glial tumors.

Objective: We aimed to elucidate the histopathological pre-diagnosis of cranial gliomas with magnetic resonance imaging (MRI) techniques in gliomas.

Method: A total of 82 glioma patients were enrolled to our study. Pre-operative conventional MRI images (non-contrast T1/T2/flair/contrast-enhanced T1) and advanced MRI images (DAG and ADC mapping, MRI spectroscopy and perfusion MRI [PMRI]) were analyzed.

Retrospective evaluation of the effects of different anesthesia methods on emergence agitation in patients undergoing vitreoretinal surgery.

Objective: The agitation that can occur in patients undergoing vitreoretinal surgery on awakening from general anesthesia is a serious post-operative problem. In our study, we aimed to compare the effects of different anesthesia methods on emergence agitation in patients undergoing vitreoretinal surgery.

Method: Patients undergoing vitreoretinal surgery were divided into two groups: Total intravenous anesthesia (Group T) and inhalation anesthesia (Group D) according to the maintenance of anesthesia applied by consulting the records.

Status of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.

Rationale: Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan.

Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute hospitals.

Methods: A multidisciplinary cross-sectional questionnaire was used to investigate sepsis care in hospitals.

Sleeve gastrectomy improves HDL function examined by Apo-A1 and atherogenic indices in non-diabetic obese patients.

Objective: Dysregulation of lipid metabolism can be one of the pathophysiological mechanisms linking high-density lipoprotein cholesterol (HDL-C) dysfunction to obesity. The aim of the study is to show possible changes in lipid metabolism with atherogenic indices in obese patients after sleeve gastrectomy (SG) surgery.

Method: Thirty patients who had SG surgery for obesity were included in the prospective study.

The Effect of Aromatherapy Massage on Cramp Frequency, Pain Intensity, and Quality of Life in Hemodialysis Patients With Muscle Cramps: A Randomized, Placebo-Controlled, Mixed Study.

Muscle cramps, which are frequently encountered in hemodialysis patients, affect individuals bio-psycho-socially, limit their activities of daily living, and reduce their quality of life. In this study, we aimed to evaluate the effects of aromatherapy massage applied in 12 sessions over 4 weeks on cramp frequency, pain severity, and quality of life. The study was conducted as a pretest-posttest, randomized controlled, and single-blinded using a quantitative and qualitative research design.

Effect of Medial Olivocochlear Efferents on Speech Discrimination in Noise in Multiple Sclerosis.

Background: Patients with multiple sclerosis (MS) experience difficulties in understanding speech in noise despite having normal hearing.

Aim: This study aimed to determine the relationship between speech discrimination in noise (SDN) and medial olivocochlear reflex levels and to compare MS patients with a control group.

Material And Methods: Sixty participants with normal hearing, comprising 30 MS patients and 30 healthy controls, were included.

Effectiveness of Using Checklist in Preventing Facial, Nasal and Head Pressure Injuries in Preterm Infants in Nasal Noninvasive Mechanic Ventilation: A Quasi-Experimental Study.

Background: Noninvasive mechanical ventilation (NIMV), when in synchronized intermittent mandatory ventilation, continuous positive airway pressure, or patient-triggered ventilation modes, is known to be a cause of facial, nasal, head, and skin pressure injuries in preterm infants.

Objective: The objective of this study is to examine the efficacy of using a checklist with preterm infants under nasal NIMV in preventing facial, nasal, and head pressure injuries.

Method: The study was conducted quasi-experimentally on preterm infants under NIMV.

Evaluation of the effects of different mydriatic drops used on choroidal vascularity in healthy children.

Purpose: To evaluate the effects of mydriatics drops used primarily in routine eye examinations on the choroid tissue, which has a dense vascular network in the eye.

Methods: This prospective observational study included 90 eyes of 90 healthy children. Optical coherence tomography (OCT) images were obtained for all children before dilation.

Artificial Doctors: Performance of Chatbots as a Tool for Patient Education on Keratoconus.

Purpose: We aimed to compare the answers given by ChatGPT, Bard, and Copilot and that obtained from the American Academy of Ophthalmology (AAO) website to patient-written questions related to keratoconus in terms of accuracy, understandability, actionability, and readability to find out whether chatbots can be used in patient education.

Methods: Twenty patient-written questions obtained from the AAO website related to keratoconus were asked to ChatGPT, Bard, and Copilot. Two ophthalmologists independently assessed the answers obtained from chatbots and the AAO website in terms of accuracy, understandability, and actionability according to the Structure of Observed Learning Outcome taxonomy, Patient Education Materials Assessment Tool-Understandability, and Patient Education Materials Assessment Tool-Actionability tests, respectively.

Comparative Analysis of Cosmetic and Functional Outcomes in Corneal Tattooing (Keratopigmentation) versus Ocular Prosthesis.

Objectives: This study compares the cosmetic and functional outcomes of corneal tattooing/keratopigmentation and ocular prostheses in rehabilitating disfigured eyes, focusing on esthetic appearance and emotional well-being.

Methods: Ninety-two patients were included: 48 received corneal tattooing, and 44 were fitted with ocular prostheses. Anophthalmic surgery was indicated for trauma, painful blind eye, endophthalmitis, tumor, and corneal ulcer, while corneal tattooing was performed for trauma, corneal ulcer, and endophthalmitis.

Predicting postoperative atrial fibrillation after cardiac surgery using the Naples prognostic score.

Introduction: The Naples prognostic score (NPS) is a novel indicator of nutritional and inflammatory statuses in cancer patients. Development of atrial fibrillation after cardiac surgery (POAF) is a common complication that increases the incidence of adverse events. Numerous studies have investigated predictors of POAF.

Eating Disorder Risk Factors and the Impact of Obesity in Patients With Psoriasis.

Current evidence indicates that obesity may initiate psoriasis or worsen existing disease. Various factors contribute to the development of obesity, including eating disorders (EDs). The aim of this study was to screen for and identify factors associated with EDs in patients with psoriasis and their impact on the development of obesity in this population.

Let-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B.

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of the target genes in the cell. Breast cancer is responsible for the majority of cancer-related deaths among women globally. It has been proven that deregulated miRNAs may play an essential role in the progression of breast cancer.

Chronic disease risk factors among hospital employees: A cross-sectional study in Türkiye.

Introduction: Chronic diseases have become a significant public health problem with the prolongation of human life. There are four main behavioral risk factors for mortality. This study evaluated the significant risk factors for chronic diseases in university hospital employees.

Hemoglobin, albumin, lymphocyte and platelet (HALP) score for predicting early and late mortality in elderly patients with proximal femur fractures.

Background: Predicting mortality and morbidity poses a significant challenge to physicians, leading to the development of various scoring systems. Among these, the hemoglobin, albumin, lymphocyte and platelet (HALP) score evaluates a patient's nutritional and immune status. The primary aim of this study was to determine the predictive effect of the HALP score on 30-day and 1-year mortality in elderly patients with proximal femoral fractures (PFFs).

Surgical treatment of a giant hydatid cyst in the interventricular septum.

The surgical procedure detailed in this case report focuses on the treatment of a large cardiac hydatid cyst located in the intraventricular septum. The surgical intervention comprised a comprehensive approach involving a median sternotomy and cardiopulmonary bypass. A localized mass below the tricuspid valve at the basal region of the interventricular septum was revealed.